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TargetAmyloid-beta precursor protein(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305469(N-(3-(2-amino-4-cyclohexyl-1-methyl-5-oxo-4,5-dihy...)
Affinity DataEC50:  180nMAssay Description:Inhibition of human recombinant APP expressed in CHO-K1 cells assessed as reduction of amyloid beta level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300710(8,8-diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrim...)
Affinity DataEC50:  1.60E+4nMAssay Description:Inhibition of human recombinant APP expressed in CHO-K1 cells assessed as reduction of amyloid beta level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-on...)
Affinity DataEC50:  4.17E+3nMAssay Description:Inhibition of human recombinant APP expressed in CHO-K1 cells assessed as reduction of amyloid beta level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305467(2-amino-4-cyclohexyl-1-methyl-4-phenyl-1H-imidazol...)
Affinity DataEC50:  810nMAssay Description:Inhibition of human recombinant APP expressed in CHO-K1 cells assessed as reduction of amyloid beta level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305483(2-amino-4,4-dicyclohexyl-1-methyl-1H-imidazol-5(4H...)
Affinity DataEC50:  1.03E+3nMAssay Description:Inhibition of human recombinant APP expressed in CHO-K1 cells assessed as reduction of amyloid beta level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35595(pyrazolo pyrimidine, 28)
Affinity DataIC50: 0.0800nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35592(pyrazolo pyrimidine, 24)
Affinity DataIC50: 0.200nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35593(pyrazolo pyrimidine, 25)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35589(pyrazolo pyrimidine, 21)
Affinity DataIC50: 0.320nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35594(pyrazolo pyrimidine, 27)
Affinity DataIC50: 0.340nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35578(pyrazolo pyrimidine, 10)
Affinity DataIC50: 0.380nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35591(pyrazolo pyrimidine, 23)
Affinity DataIC50: 0.450nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35585(pyrazolo pyrimidine, 18)
Affinity DataIC50: 0.460nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35580(pyrazolo pyrimidine, 13)
Affinity DataIC50: 0.520nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35590(pyrazolo pyrimidine, 22)
Affinity DataIC50: 0.610nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35586(pyrazolo pyrimidine, 26)
Affinity DataIC50: 0.830nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35588(pyrazolo pyrimidine, 20)
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35584(pyrazolo pyrimidine, 17)
Affinity DataIC50: 1.10nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35579(pyrazolo pyrimidine, 6)
Affinity DataIC50: 1.40nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35577(pyrazolo pyrimidine, 12)
Affinity DataIC50: 1.5nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35583(pyrazolo pyrimidine, 16)
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50426487(CHEMBL2322708)
Affinity DataIC50: 2nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35582(pyrazolo pyrimidine, 15)
Affinity DataIC50: 2.10nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35587(pyrazolo pyrimidine, 19)
Affinity DataIC50: 4.30nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35575(pyrazolo pyrimidine, 9)
Affinity DataIC50: 4.60nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM35595(pyrazolo pyrimidine, 28)
Affinity DataIC50: 6nMT: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35573(pyrazolo pyrimidine, 7)
Affinity DataIC50: 7nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProgesterone receptor(Human)
Women'S Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50118694(4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35572(JMC527081 Compound 5f | pyrazolo pyrimidine, 1)
Affinity DataIC50: 9.60nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295369((2R)-4-(4-(4-Fluoro-2-(trifluoromethyl)phenyl)-2-m...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human 11betaHSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295370((2R)-3-Chloro-4-({(2R)-4-[4-fluoro-2-(trifluoromet...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse 11betaHSD1 expressed in CHO cells in presence of 10 % (v/v) human serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295375((2R)-4-(4-(4-Fluoro-2-(trifluoromethyl)phenyl)-2-m...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse 11betaHSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295377((2R)-1-(4-Bromo-2-chlorophenylsulfonyl)-4-(4-fluor...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human 11betaHSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295377((2R)-1-(4-Bromo-2-chlorophenylsulfonyl)-4-(4-fluor...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse 11betaHSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295377((2R)-1-(4-Bromo-2-chlorophenylsulfonyl)-4-(4-fluor...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse 11betaHSD1 expressed in CHO cells in presence of 10 % (v/v) human serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295378((2R)-3-Chloro-4-(4-(4-fluoro-2-(trifluoromethyl)ph...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse 11betaHSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295378((2R)-3-Chloro-4-(4-(4-fluoro-2-(trifluoromethyl)ph...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse 11betaHSD1 expressed in CHO cells in presence of 10 % (v/v) human serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295379((2R)-1-[(2-Chloro-4-pyrrolidin-1-ylphenyl)sulfonyl...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse 11betaHSD1 expressed in CHO cells in presence of 10 % (v/v) human serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295381((2R)-1-{[2-Chloro-4-(4-fluoropiperidin-1-yl)phenyl...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse 11betaHSD1 expressed in CHO cells in presence of 10 % (v/v) human serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295383((2R)-1-[3-Chloro-4-({(2R)-4-[4-fluoro-2-(trifluoro...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse 11betaHSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295383((2R)-1-[3-Chloro-4-({(2R)-4-[4-fluoro-2-(trifluoro...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse 11betaHSD1 expressed in CHO cells in presence of 10 % (v/v) human serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295384((2R)-1-(3-Chloro-4-(2-fluoro-4-(4-fluoro-2-(triflu...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human 11betaHSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295384((2R)-1-(3-Chloro-4-(2-fluoro-4-(4-fluoro-2-(triflu...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse 11betaHSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295385((2R)-1-(3-Chloro-4-(4-(4-fluoro-2-(trifluoromethyl...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human 11betaHSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295385((2R)-1-(3-Chloro-4-(4-(4-fluoro-2-(trifluoromethyl...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse 11betaHSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295386((2R)-1-(3-Chloro-4-(4-(4-fluoro-2-(trifluoromethyl...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse 11betaHSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295386((2R)-1-(3-Chloro-4-(4-(4-fluoro-2-(trifluoromethyl...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse 11betaHSD1 expressed in CHO cells in presence of 10 % (v/v) human serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295387((2R)-4-[3-Chloro-4-({(2R)-4-[4-fluoro-2-(trifluoro...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human 11betaHSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295387((2R)-4-[3-Chloro-4-({(2R)-4-[4-fluoro-2-(trifluoro...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse 11betaHSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50295387((2R)-4-[3-Chloro-4-({(2R)-4-[4-fluoro-2-(trifluoro...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse 11betaHSD1 expressed in CHO cells in presence of 10 % (v/v) human serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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