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Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458550(CHEMBL4209274)
Affinity DataEC50:  188nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458550(CHEMBL4209274)
Affinity DataEC50:  186nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458558(CHEMBL4210782)
Affinity DataEC50:  166nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458557(CHEMBL4215875)
Affinity DataEC50:  41nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  48nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458558(CHEMBL4210782)
Affinity DataEC50:  165nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458553(CHEMBL4218672)
Affinity DataEC50:  135nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458557(CHEMBL4215875)
Affinity DataEC50:  41nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  48nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458555(CHEMBL4207884)
Affinity DataEC50:  162nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458553(CHEMBL4218672)
Affinity DataEC50:  135nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458555(CHEMBL4207884)
Affinity DataEC50:  162nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458554(CHEMBL4218801)
Affinity DataEC50:  112nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50458554(CHEMBL4218801)
Affinity DataEC50:  113nMAssay Description:Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50204667(CHEMBL3943658)
Affinity DataEC50:  3.20E+3nMAssay Description:Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  5.80nMAssay Description:Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50204667(CHEMBL3943658)
Affinity DataEC50:  3.16E+3nMAssay Description:Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50204672(CHEMBL3961059)
Affinity DataEC50:  550nMAssay Description:Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  5.80nMAssay Description:Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50204672(CHEMBL3961059)
Affinity DataEC50:  550nMAssay Description:Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2018
Entry Details Article
PubMed
TargetTranslocator protein(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM22032(PK 11195 | PK11195 | RP 52028 | N-(butan-2-yl)-1-(...)
Affinity DataKd:  11nMAssay Description:Binding affinity to recombinant human TSPO by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2018
Entry Details Article
PubMed
TargetTranslocator protein(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50210940(CHEMBL3948914)
Affinity DataKd:  108nMAssay Description:Binding affinity to recombinant human TSPO by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2018
Entry Details Article
PubMed
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: 0.280nMAssay Description:Ability to inhibit [3H]haloperidol binding to dopamine receptor in rat striatal homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of [3H]haloperidol binding to dopamine receptors in rat striatal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2018
Entry Details Article
PubMed
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of [3H]haloperidol binding to dopamine receptors in rat striatal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2018
Entry Details Article
PubMed
LigandPNGBDBM50225369(CHEMBL295712)
Affinity DataIC50: 0.610nMAssay Description:Inhibition of [3H]haloperidol binding to dopamine receptors in rat striatal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50098551((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTranslocator protein(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50185957(N-(4-chloro-2-phenoxyphenyl)-N-(2-isopropoxybenzyl...)
Affinity DataIC50: 0.920nMAssay Description:Inhibition of TSPO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50098551((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Affinity DataIC50: 0.933nMAssay Description:Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTranslocator protein(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM22032(PK 11195 | PK11195 | RP 52028 | N-(butan-2-yl)-1-(...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of TSPO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2018
Entry Details Article
PubMed
TargetTranslocator protein(Rat)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM22032(PK 11195 | PK11195 | RP 52028 | N-(butan-2-yl)-1-(...)
Affinity DataIC50: 1.30nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat cerebral cortex membranes after 60 mins by microbeta liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTranslocator protein(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50210943(CHEMBL3970955)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of TSPO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50098551((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Affinity DataIC50: 3.70nMAssay Description:Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50098551((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Affinity DataIC50: 3.70nMAssay Description:Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2018
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 6nMAssay Description:Inhibition of c-RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50345949(3-(4-Methoxy-phenyl)-9-prop-2-ynylamino-3H-pyrido[...)
Affinity DataIC50: 6.70nMAssay Description:Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2016
Entry Details Article
PubMed
LigandPNGBDBM50225510(CHEMBL156395)
Affinity DataIC50: 13nMAssay Description:Inhibition of [3H]haloperidol binding to dopamine receptors in rat striatal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2018
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50048844(CHEMBL3310332)
Affinity DataIC50: 14nMAssay Description:Inhibition of ROS1 (unknown origin) assessed as remaining activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50210941(CHEMBL3899686)
Affinity DataIC50: 20nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells by automated patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2018
Entry Details Article
PubMed
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataIC50: 20nMAssay Description:The compound was tested for inhibition of [3H]WB-4101 binding to alpha-1 adrenergic receptor of rat frontal cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50048850(CHEMBL3310338)
Affinity DataIC50: 25nMAssay Description:Inhibition of ROS1 (unknown origin) assessed as remaining activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50058042(CHEMBL3330823)
Affinity DataIC50: 45nMAssay Description:Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2016
Entry Details Article
PubMed
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataIC50: 48nMAssay Description:The compound was tested for inhibition of [3H]QNB binding to Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50058048(CHEMBL3330811)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2016
Entry Details Article
PubMed
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: 54nMAssay Description:The compound was tested for inhibition of [3H]QNB binding to Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50048849(CHEMBL3310337)
Affinity DataIC50: 57nMAssay Description:Inhibition of ROS1 (unknown origin) assessed as remaining activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50058044(CHEMBL3330817)
Affinity DataIC50: 57nMAssay Description:Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50058056(CHEMBL3330801)
Affinity DataIC50: 58nMAssay Description:Antagonist activity at mGluR1 (unknown origin) expressed in Chem-3 cells assessed as inhibition of glutamate-induced increased intracellular calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50048857(CHEMBL3310324)
Affinity DataIC50: 59nMAssay Description:Inhibition of ROS1 (unknown origin) assessed as remaining activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: 60nMAssay Description:Inhibition of ROS1 (unknown origin) assessed as remaining activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2016
Entry Details Article
PubMed
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