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TargetReplicase polyprotein 1ab(2019-nCoV)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50591389(CHEMBL5179778)
Affinity DataKi:  56nMAssay Description:Irreversible inhibition of recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli using Ac-Abu-Tle-Leu-Gln-MCA as fluorogenic substr...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50591390(CHEMBL5190754)
Affinity DataKi:  224nMAssay Description:Irreversible inhibition of recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli using Ac-Abu-Tle-Leu-Gln-MCA as fluorogenic substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM50590308(CHEMBL5201689)
Affinity DataKi:  3.02E+3nMAssay Description:Competitive inhibition of biotinylated heparin binding to His-tagged wild type SARS-COV-2 spike protein assessed inhibition constant incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM496902(CVD-0018409 | PF-07321332 | US11351149, Example 13...)
Affinity DataIC50:  0.790nMAssay Description:Inhibition of recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli using Ac-Abu-Tle-Leu-Gln-MCA as fluorogenic substrate preincuba...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM420298(CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli using Ac-Abu-Tle-Leu-Gln-MCA as fluorogenic substrate preincuba...More data for this Ligand-Target Pair
Ligand InfoPurchasePDB
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TargetReplicase polyprotein 1ab(2019-nCoV)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50591389(CHEMBL5179778)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli using Ac-Abu-Tle-Leu-Gln-MCA as fluorogenic substrate preincuba...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50591391(CHEMBL5179611)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli using Ac-Abu-Tle-Leu-Gln-MCA as fluorogenic substrate preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50591388(CHEMBL5198073)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli using Ac-Abu-Tle-Leu-Gln-MCA as fluorogenic substrate preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50591392(CHEMBL5195394)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli using Ac-Abu-Tle-Leu-Gln-MCA as fluorogenic substrate preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50591390(CHEMBL5190754)
Affinity DataIC50:  28nMAssay Description:Inhibition of recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli using Ac-Abu-Tle-Leu-Gln-MCA as fluorogenic substrate preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50591394(CHEMBL5172924)
Affinity DataIC50:  332nMAssay Description:Inhibition of recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli using Ac-Abu-Tle-Leu-Gln-MCA as fluorogenic substrate preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50591393(CHEMBL5197241)
Affinity DataIC50:  464nMAssay Description:Inhibition of recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli using Ac-Abu-Tle-Leu-Gln-MCA as fluorogenic substrate preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCathepsin B(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50591389(CHEMBL5179778)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of C-terminal His-tagged Human cathepsin B expressed in FreeStyle 293-F cells using Z-Leu-Arg-MCA peptide as fluorogenic substrate preincu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProcathepsin L(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50591389(CHEMBL5179778)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of C-terminal His-tagged recombinant Human cathepsin L (18 to 333 residues) expressed in FreeStyle 293-F cells using Z-Leu-Arg-MCA peptide...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin S(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50591389(CHEMBL5179778)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of C-terminal His-tagged recombinant Human cathepsin S (17 to 331 residues) expressed in FreeStyle 293-F cells using Z-Leu-Arg-MCA peptide...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM50590308(CHEMBL5201689)
Affinity DataIC50:  8.69E+4nMAssay Description:Competitive inhibition of biotinylated heparin binding to His-tagged wild type SARS-COV-2 spike protein incubated for 300 sec by biolayer interferome...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed