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TargetB-cell lymphoma 6 protein(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50260534(CHEMBL4066375)
Affinity DataKd:  1.29E+5nMAssay Description:Binding affinity to recombinant RED-NHS labelled BCL6 BTB domain (1 to 129 residues) (unknown origin) after 10 mins by microscale thermophoresis meth...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetB-cell lymphoma 6 protein(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50260529(CHEMBL4077626)
Affinity DataKd:  0.570nMAssay Description:Binding affinity to biotinylated BCL6 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetB-cell lymphoma 6 protein(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50260527(CHEMBL4096591)
Affinity DataKd:  2.40E+4nMAssay Description:Binding affinity to wild-type avi-tagged BCL6 BTB domain (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetB-cell lymphoma 6 protein(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50260528(CHEMBL4063725)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity to wild-type avi-tagged BCL6 BTB domain (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetB-cell lymphoma 6 protein(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50239395(CHEMBL4061302)
Affinity DataKd:  7.00E+3nMAssay Description:Binding affinity to recombinant RED-NHS labelled BCL6 BTB domain (1 to 129 residues) (unknown origin) after 10 mins by microscale thermophoresis meth...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataEC50:  0.0220nMAssay Description:Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaS...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103443(US8552037, 90)
Affinity DataEC50:  0.0150nMAssay Description:Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataEC50:  0.850nMAssay Description:Agonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaS...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103443(US8552037, 90)
Affinity DataEC50:  0.510nMAssay Description:Agonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataEC50:  0.0260nMAssay Description:Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50347588(CHEMBL1802025)
Affinity DataEC50:  0.530nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataEC50:  0.820nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50347588(CHEMBL1802025)
Affinity DataEC50:  0.0210nMAssay Description:Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103448(US8552037, 95)
Affinity DataIC50: 0.0220nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103446(US8552037, 93)
Affinity DataIC50: 0.0300nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103450(US8552037, 98)
Affinity DataIC50: 0.0380nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103446(US8552037, 93)
Affinity DataIC50: 0.0490nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103443(US8552037, 90)
Affinity DataIC50: 0.0570nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103437(US8552037, 82)
Affinity DataIC50: 0.0680nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103439(US8552037, 84)
Affinity DataIC50: 0.0790nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50240305(CHEMBL4082370)
Affinity DataIC50: 0.0860nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus expression system using fluorescein-PKC as substrate preincub...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103448(US8552037, 95)
Affinity DataIC50: 0.0910nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103456(US8552037, 123)
Affinity DataIC50: 0.0950nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103450(US8552037, 98)
Affinity DataIC50: 0.120nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103445(US8552037, 92)
Affinity DataIC50: 0.130nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103443(US8552037, 90)
Affinity DataIC50: 0.130nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103456(US8552037, 123)
Affinity DataIC50: 0.140nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103442(US8552037, 89)
Affinity DataIC50: 0.150nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103449(US8552037, 97)
Affinity DataIC50: 0.150nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50240307(CHEMBL4065996)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus expression system using fluorescein-PKC as substrate preincub...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103440(US8552037, 86)
Affinity DataIC50: 0.190nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103438(US8552037, 83)
Affinity DataIC50: 0.220nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103440(US8552037, 86)
Affinity DataIC50: 0.220nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103437(US8552037, 82)
Affinity DataIC50: 0.240nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103438(US8552037, 83)
Affinity DataIC50: 0.25nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103455(US8552037, 121)
Affinity DataIC50: 0.25nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103445(US8552037, 92)
Affinity DataIC50: 0.280nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103449(US8552037, 97)
Affinity DataIC50: 0.280nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103454(US8552037, 116)
Affinity DataIC50: 0.280nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103441(US8552037, 87)
Affinity DataIC50: 0.310nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103442(US8552037, 89)
Affinity DataIC50: 0.310nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103436(US8552037, 81)
Affinity DataIC50: 0.330nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103452(US8552037, 100)
Affinity DataIC50: 0.360nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103436(US8552037, 81)
Affinity DataIC50: 0.370nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103452(US8552037, 100)
Affinity DataIC50: 0.410nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103439(US8552037, 84)
Affinity DataIC50: 0.430nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166601(CHEMBL3798679)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103454(US8552037, 116)
Affinity DataIC50: 0.540nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103453(US8552037, 107)
Affinity DataIC50: 0.660nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

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