Compile Data Set for Download or QSAR
Found 630 with Last Name = 'takeuchi' and Initial = 'j'
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312261((4-(4-bromo-3,5-bis(trifluoromethyl)phenylcarbamoy...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1cc(c(Br)c(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H9BrF8NO4P/c17-12-10(14(18,19)20)5-9(6-11(12)15(21,22)23)26-13(27)7-1-3-8(4-2-7)16(24,25)31(28,29)30/h1-6H,(H,26,27)(H2,28,29,30)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312266((4-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)pheny...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(NC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1
Show InChI InChI=1S/C16H11F8N2O4P/c17-14(18,19)9-5-10(15(20,21)22)7-12(6-9)26-13(27)25-11-3-1-8(2-4-11)16(23,24)31(28,29)30/h1-7H,(H2,25,26,27)(H2,28,29,30)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312260((4-(3,5-bis(trifluoromethyl)phenylcarbamoyl)phenyl...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H10F8NO4P/c17-14(18,19)10-5-11(15(20,21)22)7-12(6-10)25-13(26)8-1-3-9(4-2-8)16(23,24)30(27,28)29/h1-7H,(H,25,26)(H2,27,28,29)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312259((4-(4-bromo-3-(trifluoromethyl)phenylcarbamoyl)phe...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1ccc(Br)c(c1)C(F)(F)F
Show InChI InChI=1S/C15H10BrF5NO4P/c16-12-6-5-10(7-11(12)14(17,18)19)22-13(23)8-1-3-9(4-2-8)15(20,21)27(24,25)26/h1-7H,(H,22,23)(H2,24,25,26)
Affinity DataKi:  4.90E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312258((4-(4-chloro-3-(trifluoromethyl)phenylcarbamoyl)ph...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C15H10ClF5NO4P/c16-12-6-5-10(7-11(12)14(17,18)19)22-13(23)8-1-3-9(4-2-8)15(20,21)27(24,25)26/h1-7H,(H,22,23)(H2,24,25,26)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312256((4-(4-bromophenylcarbamoyl)phenyl)difluoromethylph...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C14H11BrF2NO4P/c15-11-5-7-12(8-6-11)18-13(19)9-1-3-10(4-2-9)14(16,17)23(20,21)22/h1-8H,(H,18,19)(H2,20,21,22)
Affinity DataKi:  1.03E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312252(CHEMBL1080488 | difluoro(4-(3-(trifluoromethyl)phe...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C15H11F5NO4P/c16-14(17,18)11-2-1-3-12(8-11)21-13(22)9-4-6-10(7-5-9)15(19,20)26(23,24)25/h1-8H,(H,21,22)(H2,23,24,25)
Affinity DataKi:  1.07E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312257(CHEMBL1080667 | difluoro(4-(4-fluoro-3-(trifluorom...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C15H10F6NO4P/c16-12-6-5-10(7-11(12)14(17,18)19)22-13(23)8-1-3-9(4-2-8)15(20,21)27(24,25)26/h1-7H,(H,22,23)(H2,24,25,26)
Affinity DataKi:  1.14E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight phosphotyrosine protein phosphatase(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50312261((4-(4-bromo-3,5-bis(trifluoromethyl)phenylcarbamoy...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1cc(c(Br)c(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H9BrF8NO4P/c17-12-10(14(18,19)20)5-9(6-11(12)15(21,22)23)26-13(27)7-1-3-8(4-2-7)16(24,25)31(28,29)30/h1-6H,(H,26,27)(H2,28,29,30)
Affinity DataKi:  1.48E+4nMAssay Description:Inhibition of human HCPTPAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312255((4-(4-chlorophenylcarbamoyl)phenyl)difluoromethylp...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C14H11ClF2NO4P/c15-11-5-7-12(8-6-11)18-13(19)9-1-3-10(4-2-9)14(16,17)23(20,21)22/h1-8H,(H,18,19)(H2,20,21,22)
Affinity DataKi:  1.68E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312251((4-(3-bromophenylcarbamoyl)phenyl)difluoromethylph...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1cccc(Br)c1
Show InChI InChI=1S/C14H11BrF2NO4P/c15-11-2-1-3-12(8-11)18-13(19)9-4-6-10(7-5-9)14(16,17)23(20,21)22/h1-8H,(H,18,19)(H2,20,21,22)
Affinity DataKi:  1.82E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312254(CHEMBL1080494 | difluoro(4-(4-(trifluoromethyl)phe...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H11F5NO4P/c16-14(17,18)10-5-7-12(8-6-10)21-13(22)9-1-3-11(4-2-9)15(19,20)26(23,24)25/h1-8H,(H,21,22)(H2,23,24,25)
Affinity DataKi:  1.85E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312253(CHEMBL1075857 | difluoro(4-(4-fluorophenylcarbamoy...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C14H11F3NO4P/c15-11-5-7-12(8-6-11)18-13(19)9-1-3-10(4-2-9)14(16,17)23(20,21)22/h1-8H,(H,18,19)(H2,20,21,22)
Affinity DataKi:  2.27E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312244(CHEMBL1080018 | difluoro(4-(phenylcarbamoyl)phenyl...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C14H12F2NO4P/c15-14(16,22(19,20)21)11-8-6-10(7-9-11)13(18)17-12-4-2-1-3-5-12/h1-9H,(H,17,18)(H2,19,20,21)
Affinity DataKi:  2.40E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312243(CHEMBL1080017 | difluoro(4-(thiazol-2-ylcarbamoyl)...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1nccs1
Show InChI InChI=1S/C11H9F2N2O4PS/c12-11(13,20(17,18)19)8-3-1-7(2-4-8)9(16)15-10-14-5-6-21-10/h1-6H,(H,14,15,16)(H2,17,18,19)
Affinity DataKi:  3.30E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312250((4-(3-chlorophenylcarbamoyl)phenyl)difluoromethylp...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C14H11ClF2NO4P/c15-11-2-1-3-12(8-11)18-13(19)9-4-6-10(7-5-9)14(16,17)23(20,21)22/h1-8H,(H,18,19)(H2,20,21,22)
Affinity DataKi:  3.49E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312249(CHEMBL1080201 | difluoro(4-(3-fluorophenylcarbamoy...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1cccc(F)c1
Show InChI InChI=1S/C14H11F3NO4P/c15-11-2-1-3-12(8-11)18-13(19)9-4-6-10(7-5-9)14(16,17)23(20,21)22/h1-8H,(H,18,19)(H2,20,21,22)
Affinity DataKi:  4.18E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312242((4-(benzylcarbamoyl)phenyl)difluoromethylphosphoni...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C15H14F2NO4P/c16-15(17,23(20,21)22)13-8-6-12(7-9-13)14(19)18-10-11-4-2-1-3-5-11/h1-9H,10H2,(H,18,19)(H2,20,21,22)
Affinity DataKi:  4.31E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312248((4-(2-bromophenylcarbamoyl)phenyl)difluoromethylph...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1ccccc1Br
Show InChI InChI=1S/C14H11BrF2NO4P/c15-11-3-1-2-4-12(11)18-13(19)9-5-7-10(8-6-9)14(16,17)23(20,21)22/h1-8H,(H,18,19)(H2,20,21,22)
Affinity DataKi:  4.46E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312241(CHEMBL1081937 | difluoro(4-(2,2,2-trifluoroethylca...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C10H9F5NO4P/c11-9(12,13)5-16-8(17)6-1-3-7(4-2-6)10(14,15)21(18,19)20/h1-4H,5H2,(H,16,17)(H2,18,19,20)
Affinity DataKi:  4.97E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312247(CHEMBL1075838 | difluoro(4-(2-(trifluoromethyl)phe...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1ccccc1C(F)(F)F
Show InChI InChI=1S/C15H11F5NO4P/c16-14(17,18)11-3-1-2-4-12(11)21-13(22)9-5-7-10(8-6-9)15(19,20)26(23,24)25/h1-8H,(H,21,22)(H2,23,24,25)
Affinity DataKi:  5.48E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312240(CHEMBL1081936 | difluoro(4-(phenethylcarbamoyl)phe...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C16H16F2NO4P/c17-16(18,24(21,22)23)14-8-6-13(7-9-14)15(20)19-11-10-12-4-2-1-3-5-12/h1-9H,10-11H2,(H,19,20)(H2,21,22,23)
Affinity DataKi:  6.16E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312231((4-benzamidophenyl)difluoromethylphosphonic acid |...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C14H12F2NO4P/c15-14(16,22(19,20)21)11-6-8-12(9-7-11)17-13(18)10-4-2-1-3-5-10/h1-9H,(H,17,18)(H2,19,20,21)
Affinity DataKi:  6.55E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312246((4-(2-chlorophenylcarbamoyl)phenyl)difluoromethylp...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1ccccc1Cl
Show InChI InChI=1S/C14H11ClF2NO4P/c15-11-3-1-2-4-12(11)18-13(19)9-5-7-10(8-6-9)14(16,17)23(20,21)22/h1-8H,(H,18,19)(H2,20,21,22)
Affinity DataKi:  6.80E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312239((4-(cyclopentylcarbamoyl)phenyl)difluoromethylphos...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)NC1CCCC1
Show InChI InChI=1S/C13H16F2NO4P/c14-13(15,21(18,19)20)10-7-5-9(6-8-10)12(17)16-11-3-1-2-4-11/h5-8,11H,1-4H2,(H,16,17)(H2,18,19,20)
Affinity DataKi:  7.24E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312230(CHEMBL1081583 | difluoro(4-nitrophenyl)methylphosp...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C7H6F2NO5P/c8-7(9,16(13,14)15)5-1-3-6(4-2-5)10(11)12/h1-4H,(H2,13,14,15)
Affinity DataKi:  7.54E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312234((2-benzyl-2H-indazol-5-yl)difluoromethylphosphonic...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc2nn(Cc3ccccc3)cc2c1
Show InChI InChI=1S/C15H13F2N2O3P/c16-15(17,23(20,21)22)13-6-7-14-12(8-13)10-19(18-14)9-11-4-2-1-3-5-11/h1-8,10H,9H2,(H2,20,21,22)
Affinity DataKi:  8.44E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312229((4-bromophenyl)difluoromethylphosphonic acid | CHE...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(Br)cc1
Show InChI InChI=1S/C7H6BrF2O3P/c8-6-3-1-5(2-4-6)7(9,10)14(11,12)13/h1-4H,(H2,11,12,13)
Affinity DataKi:  9.23E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein phosphatase F(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50312261((4-(4-bromo-3,5-bis(trifluoromethyl)phenylcarbamoy...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1cc(c(Br)c(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H9BrF8NO4P/c17-12-10(14(18,19)20)5-9(6-11(12)15(21,22)23)26-13(27)7-1-3-8(4-2-7)16(24,25)31(28,29)30/h1-6H,(H,26,27)(H2,28,29,30)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human LARMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein phosphatase C(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50312261((4-(4-bromo-3,5-bis(trifluoromethyl)phenylcarbamoy...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1cc(c(Br)c(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H9BrF8NO4P/c17-12-10(14(18,19)20)5-9(6-11(12)15(21,22)23)26-13(27)7-1-3-8(4-2-7)16(24,25)31(28,29)30/h1-6H,(H,26,27)(H2,28,29,30)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human CD45More data for this Ligand-Target Pair
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50312261((4-(4-bromo-3,5-bis(trifluoromethyl)phenylcarbamoy...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1cc(c(Br)c(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H9BrF8NO4P/c17-12-10(14(18,19)20)5-9(6-11(12)15(21,22)23)26-13(27)7-1-3-8(4-2-7)16(24,25)31(28,29)30/h1-6H,(H,26,27)(H2,28,29,30)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human VHRMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50312261((4-(4-bromo-3,5-bis(trifluoromethyl)phenylcarbamoy...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1cc(c(Br)c(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H9BrF8NO4P/c17-12-10(14(18,19)20)5-9(6-11(12)15(21,22)23)26-13(27)7-1-3-8(4-2-7)16(24,25)31(28,29)30/h1-6H,(H,26,27)(H2,28,29,30)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human TCPTPMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50312261((4-(4-bromo-3,5-bis(trifluoromethyl)phenylcarbamoy...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1cc(c(Br)c(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H9BrF8NO4P/c17-12-10(14(18,19)20)5-9(6-11(12)15(21,22)23)26-13(27)7-1-3-8(4-2-7)16(24,25)31(28,29)30/h1-6H,(H,26,27)(H2,28,29,30)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human PTP1BMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50312261((4-(4-bromo-3,5-bis(trifluoromethyl)phenylcarbamoy...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1cc(c(Br)c(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H9BrF8NO4P/c17-12-10(14(18,19)20)5-9(6-11(12)15(21,22)23)26-13(27)7-1-3-8(4-2-7)16(24,25)31(28,29)30/h1-6H,(H,26,27)(H2,28,29,30)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human PtpBMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312265(CHEMBL1081955 | difluoro(4-(N-phenylsulfamoyl)phen...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C13H12F2NO5PS/c14-13(15,22(17,18)19)10-6-8-12(9-7-10)23(20,21)16-11-4-2-1-3-5-11/h1-9,16H,(H2,17,18,19)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312264(CHEMBL1079845 | difluoro(4-(phenoxymethyl)phenyl)m...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(COc2ccccc2)cc1
Show InChI InChI=1S/C14H13F2O4P/c15-14(16,21(17,18)19)12-8-6-11(7-9-12)10-20-13-4-2-1-3-5-13/h1-9H,10H2,(H2,17,18,19)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312263(CHEMBL1075973 | difluoro(4-((phenylamino)methyl)ph...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(CNc2ccccc2)cc1
Show InChI InChI=1S/C14H14F2NO3P/c15-14(16,21(18,19)20)12-8-6-11(7-9-12)10-17-13-4-2-1-3-5-13/h1-9,17H,10H2,(H2,18,19,20)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312262(CHEMBL1075905 | difluoro(4-(methyl(phenyl)carbamoy...)
Show SMILES CN(C(=O)c1ccc(cc1)C(F)(F)P(O)(O)=O)c1ccccc1
Show InChI InChI=1S/C15H14F2NO4P/c1-18(13-5-3-2-4-6-13)14(19)11-7-9-12(10-8-11)15(16,17)23(20,21)22/h2-10H,1H3,(H2,20,21,22)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312245(CHEMBL1082129 | difluoro(4-(2-fluorophenylcarbamoy...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1ccccc1F
Show InChI InChI=1S/C14H11F3NO4P/c15-11-3-1-2-4-12(11)18-13(19)9-5-7-10(8-6-9)14(16,17)23(20,21)22/h1-8H,(H,18,19)(H2,20,21,22)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312238((4-(cyclopentylmethylcarbamoyl)phenyl)difluorometh...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)NCC1CCCC1
Show InChI InChI=1S/C14H18F2NO4P/c15-14(16,22(19,20)21)12-7-5-11(6-8-12)13(18)17-9-10-3-1-2-4-10/h5-8,10H,1-4,9H2,(H,17,18)(H2,19,20,21)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312237(CHEMBL1079988 | difluoro(4-(methylcarbamoyl)phenyl...)
Show SMILES CNC(=O)c1ccc(cc1)C(F)(F)P(O)(O)=O
Show InChI InChI=1S/C9H10F2NO4P/c1-12-8(13)6-2-4-7(5-3-6)9(10,11)17(14,15)16/h2-5H,1H3,(H,12,13)(H2,14,15,16)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312236(CHEMBL1075731 | difluoro(4-(isopropylcarbamoyl)phe...)
Show SMILES CC(C)NC(=O)c1ccc(cc1)C(F)(F)P(O)(O)=O
Show InChI InChI=1S/C11H14F2NO4P/c1-7(2)14-10(15)8-3-5-9(6-4-8)11(12,13)19(16,17)18/h3-7H,1-2H3,(H,14,15)(H2,16,17,18)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312235((4-(1-ethylpiperidin-4-ylcarbamoyl)phenyl)difluoro...)
Show SMILES CCN1CCC(CC1)NC(=O)c1ccc(cc1)C(F)(F)P(O)(O)=O
Show InChI InChI=1S/C15H21F2N2O4P/c1-2-19-9-7-13(8-10-19)18-14(20)11-3-5-12(6-4-11)15(16,17)24(21,22)23/h3-6,13H,2,7-10H2,1H3,(H,18,20)(H2,21,22,23)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312233((1-benzyl-1H-indazol-5-yl)difluoromethylphosphonic...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc2n(Cc3ccccc3)ncc2c1
Show InChI InChI=1S/C15H13F2N2O3P/c16-15(17,23(20,21)22)13-6-7-14-12(8-13)9-18-19(14)10-11-4-2-1-3-5-11/h1-9H,10H2,(H2,20,21,22)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312232(CHEMBL1079660 | difluoro(3-(phenylcarbamoyl)phenyl...)
Show SMILES OP(O)(=O)C(F)(F)c1cccc(c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C14H12F2NO4P/c15-14(16,22(19,20)21)11-6-4-5-10(9-11)13(18)17-12-7-2-1-3-8-12/h1-9H,(H,17,18)(H2,19,20,21)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312228(CHEMBL1081748 | difluoro(4-(1-methyl-1H-pyrazol-4-...)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)C(F)(F)P(O)(O)=O
Show InChI InChI=1S/C11H11F2N2O3P/c1-15-7-9(6-14-15)8-2-4-10(5-3-8)11(12,13)19(16,17)18/h2-7H,1H3,(H2,16,17,18)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50075308((Biphenyl-4-yl-difluoro-methyl)-phosphonic acid | ...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C13H11F2O3P/c14-13(15,19(16,17)18)12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H,(H2,16,17,18)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312226(4-(difluoro(phosphono)methyl)benzoic acid | CHEMBL...)
Show SMILES OC(=O)c1ccc(cc1)C(F)(F)P(O)(O)=O
Show InChI InChI=1S/C8H7F2O5P/c9-8(10,16(13,14)15)6-3-1-5(2-4-6)7(11)12/h1-4H,(H,11,12)(H2,13,14,15)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
University of California

Curated by ChEMBL
LigandPNGBDBM50312227(CHEMBL1081060 | difluoro(4-(2-oxo-2-(phenylamino)e...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(CC(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C15H14F2NO4P/c16-15(17,23(20,21)22)12-8-6-11(7-9-12)10-14(19)18-13-4-2-1-3-5-13/h1-9H,10H2,(H,18,19)(H2,20,21,22)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpAMore data for this Ligand-Target Pair
TargetCysteinyl leukotriene receptor 1(Homo sapiens (Human))
Setsunan University

Curated by ChEMBL
LigandPNGBDBM50104905(CHEMBL3597618)
Show SMILES Cc1c(CCCC(O)=O)c2cccc(C#Cc3ccc(OCCCCc4cccc(Cl)c4C)cc3)c2n1CC(O)=O
Show InChI InChI=1S/C34H34ClNO5/c1-23-26(9-6-13-31(23)35)8-3-4-21-41-28-19-16-25(17-20-28)15-18-27-10-5-12-30-29(11-7-14-32(37)38)24(2)36(34(27)30)22-33(39)40/h5-6,9-10,12-13,16-17,19-20H,3-4,7-8,11,14,21-22H2,1-2H3,(H,37,38)(H,39,40)
Affinity DataIC50: 0.220nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
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