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Report error Found 7605 with Last Name = 'tam' and Initial = 's'
LigandPNGBDBM8465(CGS 27023 | CHEMBL514138 | hydroxamate analogue 1 ...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13139((2S)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 8(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25148(2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo...)
Affinity DatapH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25148(2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo...)
Affinity DataT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 5(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4 [653-1084,H976Y](Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM19410(benzamide-type inhibitor, 3 | CHEMBL27759 | pyridi...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4 [653-1084,H976Y](Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM24624(MGCD-0103 | N-(2-aminophenyl)-4-({[4-(pyridin-3-yl...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4 [653-1084,H976Y](Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25152(N-methyl-2-oxo-N'-(3-phenylphenyl)nonanediamide | ...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25150(Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...)
Affinity DataT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM19410(benzamide-type inhibitor, 3 | CHEMBL27759 | pyridi...)
Affinity DataT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM24624(MGCD-0103 | N-(2-aminophenyl)-4-({[4-(pyridin-3-yl...)
Affinity DataT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25152(N-methyl-2-oxo-N'-(3-phenylphenyl)nonanediamide | ...)
Affinity DataT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM19410(benzamide-type inhibitor, 3 | CHEMBL27759 | pyridi...)
Affinity DataT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM24624(MGCD-0103 | N-(2-aminophenyl)-4-({[4-(pyridin-3-yl...)
Affinity DataT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
P. Angeletti S.P.A. (Merck Research Laboratories)

Curated by ChEMBL
LigandPNGBDBM50158845(2-(3-(3-(2-chlorobenzyl)ureido)thiophen-2-yl)-5,6-...)
Affinity DataEC50:  9.30E+3nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
P. Angeletti S.P.A. (Merck Research Laboratories)

Curated by ChEMBL
LigandPNGBDBM50183508(5,6-dihydroxy-2-(3-{[(2-phenylethoxy)carbonyl]amin...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
P. Angeletti S.P.A. (Merck Research Laboratories)

Curated by ChEMBL
LigandPNGBDBM50183492(2-{3-[(anilinocarbonyl)amino]-2-thienyl}-5,6-dihyd...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
P. Angeletti S.P.A. (Merck Research Laboratories)

Curated by ChEMBL
LigandPNGBDBM50158845(2-(3-(3-(2-chlorobenzyl)ureido)thiophen-2-yl)-5,6-...)
Affinity DataEC50:  3.10E+3nMAssay Description:Inhibition of replication of HCV 1b BK RNA in Huh7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
P. Angeletti S.P.A. (Merck Research Laboratories)

Curated by ChEMBL
LigandPNGBDBM50183495(2-[3-({[(1-benzothien-3-ylmethyl)amino]carbonyl}am...)
Affinity DataEC50:  3.00E+4nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
P. Angeletti S.P.A. (Merck Research Laboratories)

Curated by ChEMBL
LigandPNGBDBM50183481(2-[3-(benzoylamino)-2-thienyl]-5,6-dihydroxypyrimi...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
P. Angeletti S.P.A. (Merck Research Laboratories)

Curated by ChEMBL
LigandPNGBDBM50183487(2-[3-({[(2-chlorobenzyl)oxy]carbonyl}amino)-2-thie...)
Affinity DataEC50:  3.15E+4nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
P. Angeletti S.P.A. (Merck Research Laboratories)

Curated by ChEMBL
LigandPNGBDBM50183497(5,6-dihydroxy-2-(3-{[(1-naphthylmethoxy)carbonyl]a...)
Affinity DataEC50:  1.36E+4nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
P. Angeletti S.P.A. (Merck Research Laboratories)

Curated by ChEMBL
LigandPNGBDBM50183480(2-[3-({[(2-chloro-6-methylbenzyl)amino]carbonyl}am...)
Affinity DataEC50:  1.36E+4nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
P. Angeletti S.P.A. (Merck Research Laboratories)

Curated by ChEMBL
LigandPNGBDBM50183494(2-[3-({[(2,6-dichlorobenzyl)oxy]carbonyl}amino)-2-...)
Affinity DataEC50:  1.86E+4nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
P. Angeletti S.P.A. (Merck Research Laboratories)

Curated by ChEMBL
LigandPNGBDBM50158845(2-(3-(3-(2-chlorobenzyl)ureido)thiophen-2-yl)-5,6-...)
Affinity DataEC50:  3.10E+3nMAssay Description:Inhibition of replication of HCV 1b BK RNA in Huh7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytosolic phospholipase A2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50205515(4-{2-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl...)
Affinity DataKd:  139nMAssay Description:Binding affinity to human cPLA2 alpha by isothermal calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50220842(3-butyl-1H-pyrazole-5-carboxylic acid | 5-butyl-1H...)
Affinity DataEC50:  1.40E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216520(pyrimidine-5-carboxylic acid | CHEMBL247316)
Affinity DataEC50:  2.90E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216521(5-fluoronicotinic acid | CHEMBL397783)
Affinity DataEC50:  5.30E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216522(1-methyl-1H-pyrazole-4-carboxylic acid | CHEMBL393...)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216523(6-propyl-4,6-dihydro-2H-furo[3,4-c]pyrazole-3-carb...)
Affinity DataEC50:  2.10E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216524(3-cyclobutyl-1H-pyrazole-5-carboxylic acid | 5-cyc...)
Affinity DataEC50:  1.62E+4nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216525(6-methyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole-3...)
Affinity DataEC50:  8.30E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216527(5,6-dihydro-2H-thieno[3,2-c]pyrazole-3-carboxylic ...)
Affinity DataEC50:  2.20E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216526(3-(methoxymethyl)-1H-pyrazole-5-carboxylic acid | ...)
Affinity DataEC50:  8.70E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216528(6-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole-3...)
Affinity DataEC50:  1.20E+4nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216529(6-methyl-4,6-dihydro-2H-furo[3,4-c]pyrazole-3-carb...)
Affinity DataEC50:  2.50E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216530(4,6-dihydro-2H-thieno[3,4-c]pyrazole-3-carboxylic ...)
Affinity DataEC50:  5.60E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216531(5-bromonicotinic acid | CHEMBL247336)
Affinity DataEC50:  1.36E+4nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216532(isothiazole-4-carboxylic acid | CHEMBL393226)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132135(4,6-dihydro-2H-furo[3,4-c]pyrazole-3-carboxylic ac...)
Affinity DataEC50:  2.70E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216533(5-cyclopropyl-1H-pyrazole-3-carboxylic acid | 3-cy...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216535(3-(hydroxymethyl)-1H-pyrazole-5-carboxylic acid | ...)
Affinity DataEC50:  2.50E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216534(5-methylnicotinic acid | CHEMBL247132)
Affinity DataEC50:  1.60E+4nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216536(6-propyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole-3...)
Affinity DataEC50:  6.60E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216537(3-benzyl-1H-pyrazole-5-carboxylic acid | 5-Benzyl-...)
Affinity DataEC50:  8.90E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216540(3-(methylsulfinylmethyl)-1H-pyrazole-5-carboxylic ...)
Affinity DataEC50:  4.90E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216539(5-ethyl-1H-pyrazole-3-carboxylic acid | 3-ethyl-1H...)
Affinity DataEC50:  800nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216538(3-hexyl-1H-pyrazole-5-carboxylic acid | CHEMBL2479...)
Affinity DataEC50:  5.60E+3nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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