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LigandPNGBDBM50521218(CHEMBL4434674)
Affinity DataIC50: 4nMAssay Description:Inhibition of PI3Kdelta in human PBMC assessed as reduction in cytostim-induced IFNgamma production after 20 hrs by electrochemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50: 4nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536411(CHEMBL4564931)
Affinity DataIC50: 5nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536416(CHEMBL4522825)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536417(CHEMBL4592637)
Affinity DataIC50: 13nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536413(CHEMBL4593011)
Affinity DataIC50: 20nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536415(CHEMBL4582864)
Affinity DataIC50: 63nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50: 79nMAssay Description:Inhibition of TXK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50193013(Duvelisib | INK-1147 | INK-1197 | IPI-145)
Affinity DataIC50: 96nMAssay Description:Inhibition of PI3Kgamma/delta in human whole blood assessed as inhibition of FcepsilonR1/fMLP-stimulated basophil degranulation by measuring CD63+ ce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50193013(Duvelisib | INK-1147 | INK-1197 | IPI-145)
Affinity DataIC50: 100nMAssay Description:Inhibition of PI3Kgamma/delta in human whole blood assessed as inhibition of FcepsilonR1/fMLP-stimulated basophil degranulation by measuring CD63+ ce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 158nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50: 158nMAssay Description:Inhibition of IR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50: 158nMAssay Description:Inhibition of Bmx (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536413(CHEMBL4593011)
Affinity DataIC50: 200nMAssay Description:Inhibition of PI3Kdelta in human PBMC assessed as reduction in cytostim-induced IFNgamma production after 20 hrs by electrochemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536411(CHEMBL4564931)
Affinity DataIC50: 200nMAssay Description:Inhibition of PI3Kdelta in human PBMC assessed as reduction in cytostim-induced IFNgamma production after 20 hrs by electrochemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50: 200nMAssay Description:Inhibition of CAMKK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 250nMAssay Description:Inhibition of PI3Kdelta in human PBMC assessed as reduction in cytostim-induced IFNgamma production after 20 hrs by electrochemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 251nMAssay Description:Inhibition of PI3Kdelta in human PBMC assessed as reduction in cytostim-induced IFNgamma production after 20 hrs by electrochemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50: 251nMAssay Description:Inhibition of Tec (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50: 316nMAssay Description:Inhibition of Btk (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536414(CHEMBL4522018)
Affinity DataIC50: 398nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50: 398nMAssay Description:Inhibition of Aurora-B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50: 398nMAssay Description:Inhibition of LRRK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50521218(CHEMBL4434674)
Affinity DataIC50: 501nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50521218(CHEMBL4434674)
Affinity DataIC50: 501nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50521218(CHEMBL4434674)
Affinity DataIC50: 631nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pre...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536412(CHEMBL4583379)
Affinity DataIC50: 794nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50521221(CHEMBL4468849)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536412(CHEMBL4583379)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pre...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50521221(CHEMBL4468849)
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of DNA-PK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536412(CHEMBL4583379)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536412(CHEMBL4583379)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50521221(CHEMBL4468849)
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50521221(CHEMBL4468849)
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pre...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase A(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FRAP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine kinase 2(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SPHK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ITK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LRRK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholine kinase alpha(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of choline kinase alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4-kinase type 2-alpha(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI4K2A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4-kinase alpha(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PIK4A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine kinase 1(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SPHK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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