Compile Data Set for Download or QSAR
Found 403 with Last Name = 'tess' and Initial = 'da'
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50241203(CHEMBL414357 | HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGS...)
Affinity DataKi:  0.0530nMAssay Description:Displacement of [3H]PF-06883365 from FAP-tagged human GLP-1R expressed in CHO cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50241203(CHEMBL414357 | HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGS...)
Affinity DataKi:  0.0920nMAssay Description:Displacement of [125I]GLP-1 from FAP-tagged human GLP-1R expressed in CHO cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50120502(2-Amino-N-[(R)-2-(3a-benzyl-2-tert-butyl-3-oxo-2,3...)
Affinity DataKi:  0.340nMAssay Description:In vitro binding affinity of the compound was determined against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]-ghrelin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50120504(2-Amino-N-[(R)-2-[3a-benzyl-3-oxo-2-(2,2,2-trifluo...)
Affinity DataKi:  0.450nMAssay Description:In vitro binding affinity of the compound was determined against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]-ghrelin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50240819(CHEMBL4084119)
Affinity DataKi:  4.40nMAssay Description:Displacement of [125I]GLP-1 from FAP-tagged human GLP-1R expressed in CHO cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50120505(2-Amino-N-{(R)-1-(2,4-difluoro-benzyloxymethyl)-2-...)
Affinity DataKi:  5nMAssay Description:In vitro binding affinity of the compound was determined against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]-ghrelin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50240819(CHEMBL4084119)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]PF-06883365 from FAP-tagged human GLP-1R expressed in CHO cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50083974(2-Amino-N-[(R)-2-((R)-3a-benzyl-2-methyl-3-oxo-2,3...)
Affinity DataKi:  7nMAssay Description:In vitro binding affinity of the compound was determined against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]-ghrelin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218165((R)-1-(pyridin-3-yl)-2-(2-(4-(thiazol-4-yl)phenoxy...)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218166((R)-2-(2-(4-(oxazol-4-yl)phenoxy)ethylamino)-1-(py...)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50120503(2-Amino-N-[(R)-2-(3a-benzyl-2-methyl-3-oxo-2,3,3a,...)
Affinity DataKi:  18nMAssay Description:In vitro binding affinity of the compound was determined against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]-ghrelin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218173((R)-2-(2-(4-(2-methyloxazol-4-yl)phenoxy)ethylamin...)
Affinity DataKi:  21nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218170((R)-2-(2-(4-(2-(hydroxymethyl)oxazol-4-yl)phenoxy)...)
Affinity DataKi:  30nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218168((R)-2-(2-(4-(2-ethyloxazol-4-yl)phenoxy)ethylamino...)
Affinity DataKi:  37nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218180((R)-2-(2-(4-(2-ethylthiazol-4-yl)phenoxy)ethylamin...)
Affinity DataKi:  37nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218167((R)-2-(2-(4-(2-isopropyloxazol-4-yl)phenoxy)ethyla...)
Affinity DataKi:  49nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218177((R)-2-(2-(4-(2-(benzyloxymethyl)oxazol-4-yl)phenox...)
Affinity DataKi:  50nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM349762(2-[(4-{6-[(2,4-difluorobenzyl)oxy]pyridin-2-yl}pip...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]PF-06883365 from FAP-tagged human GLP-1R expressed in CHO cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)
Affinity DataKi:  80nMAssay Description:Displacement of [3H]PF-06883365 from FAP-tagged human GLP-1R expressed in CHO cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218176((R)-1-(pyridin-3-yl)-2-(2-(4-(2-(pyridin-4-yl)thia...)
Affinity DataKi:  97nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218164((R)-2-(2-(4-(2-methylthiazol-4-yl)phenoxy)ethylami...)
Affinity DataKi:  100nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218182((R)-1-(pyridin-3-yl)-2-(2-(4-(2-(trifluoromethyl)t...)
Affinity DataKi:  100nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218164((R)-2-(2-(4-(2-methylthiazol-4-yl)phenoxy)ethylami...)
Affinity DataKi:  120nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218185((1R)-1-(pyridin-3-yl)-2-(2-(4-(2-(pyridin-3-yl)thi...)
Affinity DataKi:  120nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218172((R)-2-(2-(4-(2-cyclopentylthiazol-4-yl)phenoxy)eth...)
Affinity DataKi:  130nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218165((R)-1-(pyridin-3-yl)-2-(2-(4-(thiazol-4-yl)phenoxy...)
Affinity DataKi:  140nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218174((R)-2-(2-(4-(2-phenylthiazol-4-yl)phenoxy)ethylami...)
Affinity DataKi:  150nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218181((R)-2-(2-(4-(5-methyloxazol-4-yl)phenoxy)ethylamin...)
Affinity DataKi:  170nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218166((R)-2-(2-(4-(oxazol-4-yl)phenoxy)ethylamino)-1-(py...)
Affinity DataKi:  200nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218171((R)-2-(2-(4-(2-(methoxymethyl)oxazol-4-yl)phenoxy)...)
Affinity DataKi:  210nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218170((R)-2-(2-(4-(2-(hydroxymethyl)oxazol-4-yl)phenoxy)...)
Affinity DataKi:  270nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218167((R)-2-(2-(4-(2-isopropyloxazol-4-yl)phenoxy)ethyla...)
Affinity DataKi:  360nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)
Affinity DataKi:  360nMAssay Description:Displacement of [125I]GLP-1 from FAP-tagged human GLP-1R expressed in CHO cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218173((R)-2-(2-(4-(2-methyloxazol-4-yl)phenoxy)ethylamin...)
Affinity DataKi:  400nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218168((R)-2-(2-(4-(2-ethyloxazol-4-yl)phenoxy)ethylamino...)
Affinity DataKi:  400nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218174((R)-2-(2-(4-(2-phenylthiazol-4-yl)phenoxy)ethylami...)
Affinity DataKi:  500nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50218179((R)-2-(2-(4-(2,5-dimethyloxazol-4-yl)phenoxy)ethyl...)
Affinity DataKi:  1.55E+3nMAssay Description:Displacement of [125I]iodocyanopindolol from human adrenergic beta-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50391864(CHEMBL2147287)
Affinity DataIC50:  0nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50391858(CHEMBL2147281)
Affinity DataIC50:  0.00100nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50391863(CHEMBL2147286)
Affinity DataIC50:  0.00100nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50391867(CHEMBL2147290)
Affinity DataIC50:  0.00200nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50391860(CHEMBL2147283)
Affinity DataIC50:  0.0100nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50204367(CHEMBL410414 | dirlotapide)
Affinity DataIC50:  0.0110nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50391875(CHEMBL2147296)
Affinity DataIC50:  0.0210nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50391876(CHEMBL2147292)
Affinity DataIC50:  0.0250nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50391866(CHEMBL2147294)
Affinity DataIC50:  0.0580nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50391877(CHEMBL2147293)
Affinity DataIC50:  0.0660nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50391869(CHEMBL2147301)
Affinity DataIC50:  0.101nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50391871(CHEMBL2147298)
Affinity DataIC50:  0.105nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50391872(CHEMBL2147299)
Affinity DataIC50:  0.122nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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