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TargetPeroxisome proliferator-activated receptor alpha(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50099491(cid_3392731 | CHEMBL21241 | 2-(4-{2-[3-Cyclohexyl-...)
Affinity DataEC50:  230nMAssay Description:Transactivation of human PPARalpha LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Lucif...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50049240((+-)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)m...)
Affinity DataEC50:  300nMAssay Description:Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Lucif...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315667(2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2...)
Affinity DataEC50:  4.50E+3nMAssay Description:Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Lucif...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315666(2-(4-chloro-6-(3-phenylpropylamino)pyrimidin-2-ylt...)
Affinity DataEC50:  8.90E+3nMAssay Description:Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Lucif...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315665(2-(4-chloro-6-(phenethylamino)pyrimidin-2-ylthio)-...)
Affinity DataEC50:  1.08E+4nMAssay Description:Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Lucif...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315664(2-(4-chloro-6-(isopentylamino)pyrimidin-2-ylthio)-...)
Affinity DataEC50:  8.90E+3nMAssay Description:Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Lucif...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315663(2-(4-chloro-6-(4-fluorophenylamino)pyrimidin-2-ylt...)
Affinity DataEC50:  1.30E+4nMAssay Description:Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Lucif...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315662(2-(4-chloro-6-(4-chlorophenylamino)pyrimidin-2-ylt...)
Affinity DataEC50:  9.00E+3nMAssay Description:Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Lucif...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315661(2-(4-chloro-6-(3-chlorophenylamino)pyrimidin-2-ylt...)
Affinity DataEC50:  7.30E+3nMAssay Description:Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Lucif...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315660(2-(4-chloro-6-(4-isopropylphenylamino)pyrimidin-2-...)
Affinity DataEC50:  7.60E+3nMAssay Description:Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Lucif...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315659(2-(4-chloro-6-(3,4-dimethylphenylamino)pyrimidin-2...)
Affinity DataEC50:  7.80E+3nMAssay Description:Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Lucif...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315658(2-(4-chloro-6-(2,3-dihydro-1H-inden-5-ylamino)pyri...)
Affinity DataEC50:  6.80E+3nMAssay Description:Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Lucif...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315657(2-(4-chloro-6-(naphthalen-2-ylamino)pyrimidin-2-yl...)
Affinity DataEC50:  6.90E+3nMAssay Description:Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Lucif...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50273386(2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2...)
Affinity DataEC50:  6.20E+3nMAssay Description:Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Lucif...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM24560(2-({4-chloro-6-[(2,3-dimethylphenyl)amino]pyrimidi...)
Affinity DataEC50:  3.60E+3nMAssay Description:Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Lucif...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM24566(JMC515449 Compound 1 | Wyeth 14,643 | 2-({4-chloro...)
Affinity DataEC50:  5.37E+4nMAssay Description:Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Lucif...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337806(2-(4-(biphenyl-4-ylamino)-6-chloropyrimidin-2-ylth...)
Affinity DataIC50: 100nMAssay Description:Inhibition of 5-lipoxygenase in human PMNLMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337808(2-(4-chloro-6-(4'-cyanobiphenyl-4-ylamino)pyrimidi...)
Affinity DataIC50: 170nMAssay Description:Inhibition of 5-lipoxygenase in human PMNLMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337813(2-(4-(9H-fluoren-2-ylamino)-6-chloropyrimidin-2-yl...)
Affinity DataIC50: 240nMAssay Description:Inhibition of 5-lipoxygenase in human PMNLMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337805(2-(4-chloro-6-(3,5-di-tert-butylphenylamino)pyrimi...)
Affinity DataIC50: 260nMAssay Description:Inhibition of 5-lipoxygenase in human PMNLMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315660(2-(4-chloro-6-(4-isopropylphenylamino)pyrimidin-2-...)
Affinity DataIC50: 260nMAssay Description:Inhibition of 5-lipoxygenase in human PMNLMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337812(2-(4-(4-benzylphenylamino)-6-chloropyrimidin-2-ylt...)
Affinity DataIC50: 300nMAssay Description:Inhibition of 5-lipoxygenase in human PMNLMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337810(2-(4-chloro-6-(4-phenoxyphenylamino)pyrimidin-2-yl...)
Affinity DataIC50: 400nMAssay Description:Inhibition of 5-lipoxygenase in human PMNLMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337809(2-(4-chloro-6-(4-cyclohexylphenylamino)pyrimidin-2...)
Affinity DataIC50: 400nMAssay Description:Inhibition of 5-lipoxygenase in human PMNLMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337807(2-(4-(biphenyl-3-ylamino)-6-chloropyrimidin-2-ylth...)
Affinity DataIC50: 500nMAssay Description:Inhibition of 5-lipoxygenase in human PMNLMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315658(2-(4-chloro-6-(2,3-dihydro-1H-inden-5-ylamino)pyri...)
Affinity DataIC50: 500nMAssay Description:Inhibition of 5-lipoxygenase in human PMNLMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315657(2-(4-chloro-6-(naphthalen-2-ylamino)pyrimidin-2-yl...)
Affinity DataIC50: 500nMAssay Description:Inhibition of 5-lipoxygenase in human PMNLMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337816(2-(4-(4-benzamidophenylamino)-6-chloropyrimidin-2-...)
Affinity DataIC50: 600nMAssay Description:Inhibition of 5-lipoxygenase in human PMNLMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337811(2-(4-(biphenyl-4-ylmethylamino)-6-chloropyrimidin-...)
Affinity DataIC50: 700nMAssay Description:Inhibition of 5-lipoxygenase in human PMNLMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315661(2-(4-chloro-6-(3-chlorophenylamino)pyrimidin-2-ylt...)
Affinity DataIC50: 700nMAssay Description:Inhibition of 5-lipoxygenase in human PMNLMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315659(2-(4-chloro-6-(3,4-dimethylphenylamino)pyrimidin-2...)
Affinity DataIC50: 700nMAssay Description:Inhibition of 5-lipoxygenase in human PMNLMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50443967(CHEMBL3092283)
Affinity DataIC50: 800nMAssay Description:Inhibition of mPGES-1 in human HeLa cells using PGH2 as substrate assessed as inhibition of IL-1beta/TNFalpha-stimulated PGE2 production preincubated...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315662(2-(4-chloro-6-(4-chlorophenylamino)pyrimidin-2-ylt...)
Affinity DataIC50: 800nMAssay Description:Inhibition of 5-lipoxygenase in human PMNLMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337811(2-(4-(biphenyl-4-ylmethylamino)-6-chloropyrimidin-...)
Affinity DataIC50: 880nMAssay Description:Inhibition of mPGES-1 expressed in LPS-stimulated human A549 cells mitochondrial fraction assessed as conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337805(2-(4-chloro-6-(3,5-di-tert-butylphenylamino)pyrimi...)
Affinity DataIC50: 900nMAssay Description:Inhibition of mPGES-1 expressed in LPS-stimulated human A549 cells mitochondrial fraction assessed as conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337806(2-(4-(biphenyl-4-ylamino)-6-chloropyrimidin-2-ylth...)
Affinity DataIC50: 940nMAssay Description:Inhibition of mPGES-1 expressed in LPS-stimulated human A549 cells mitochondrial fraction assessed as conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337810(2-(4-chloro-6-(4-phenoxyphenylamino)pyrimidin-2-yl...)
Affinity DataIC50: 940nMAssay Description:Inhibition of mPGES-1 expressed in LPS-stimulated human A549 cells mitochondrial fraction assessed as conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50443968(CHEMBL3092271)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of mPGES-1 in human HeLa cells using PGH2 as substrate assessed as inhibition of IL-1beta/TNFalpha-stimulated PGE2 production preincubated...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337809(2-(4-chloro-6-(4-cyclohexylphenylamino)pyrimidin-2...)
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of mPGES-1 expressed in LPS-stimulated human A549 cells mitochondrial fraction assessed as conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337812(2-(4-(4-benzylphenylamino)-6-chloropyrimidin-2-ylt...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of mPGES-1 expressed in LPS-stimulated human A549 cells mitochondrial fraction assessed as conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337813(2-(4-(9H-fluoren-2-ylamino)-6-chloropyrimidin-2-yl...)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of mPGES-1 expressed in LPS-stimulated human A549 cells mitochondrial fraction assessed as conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337813(2-(4-(9H-fluoren-2-ylamino)-6-chloropyrimidin-2-yl...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337808(2-(4-chloro-6-(4'-cyanobiphenyl-4-ylamino)pyrimidi...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of mPGES-1 expressed in LPS-stimulated human A549 cells mitochondrial fraction assessed as conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50443969(CHEMBL3092270)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of mPGES-1 in human HeLa cells using PGH2 as substrate assessed as inhibition of IL-1beta/TNFalpha-stimulated PGE2 production preincubated...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315666(2-(4-chloro-6-(3-phenylpropylamino)pyrimidin-2-ylt...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of 5-lipoxygenase in human PMNLMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50315657(2-(4-chloro-6-(naphthalen-2-ylamino)pyrimidin-2-yl...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of mPGES-1 expressed in LPS-stimulated human A549 cells mitochondrial fraction assessed as conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337805(2-(4-chloro-6-(3,5-di-tert-butylphenylamino)pyrimi...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337807(2-(4-(biphenyl-3-ylamino)-6-chloropyrimidin-2-ylth...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of mPGES-1 expressed in LPS-stimulated human A549 cells mitochondrial fraction assessed as conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337809(2-(4-chloro-6-(4-cyclohexylphenylamino)pyrimidin-2...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337812(2-(4-(4-benzylphenylamino)-6-chloropyrimidin-2-ylt...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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