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Targetm7GpppX diphosphatase(Human)
Decode Chemistry

LigandPNGBDBM36534(D156095)
Affinity DataEC50:  104nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Decode Chemistry

LigandPNGBDBM36535(D157554)
Affinity DataEC50:  921nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Decode Chemistry

LigandPNGBDBM36536(D153215)
Affinity DataEC50:  243nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232529(5-(2-fluorobenzyloxy)quinazoline-2,4-diamine | CHE...)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Decode Chemistry

LigandPNGBDBM50232538(D156844 | CHEMBL251429 | 5-((1-(2-fluorobenzyl)pip...)
Affinity DataIC50: 7.62nM EC50:  4nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Targetm7GpppX diphosphatase(Human)
Decode Chemistry

LigandPNGBDBM36533(D157555)
Affinity DataIC50: 9.38nM EC50:  108nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Decode Chemistry

LigandPNGBDBM36531(D158963)
Affinity DataIC50: 23.4nM EC50:  223nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232565(5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-d...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232535(5-(1-(3-chlorophenyl)ethoxy)quinazoline-2,4-diamin...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232534(5-((2-fluorophenoxy)methyl)quinazoline-2,4-diamine...)
Affinity DataIC50: 39nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Decode Chemistry

LigandPNGBDBM36530(D157493)
Affinity DataIC50: 43.9nM EC50:  67nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Targetm7GpppX diphosphatase(Human)
Decode Chemistry

LigandPNGBDBM36532(D158885)
Affinity DataIC50: 101nM EC50:  795nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
Decode Chemistry

LigandPNGBDBM36529(D156676)
Affinity DataIC50: 339nM EC50:  2.54E+3nMAssay Description:In vitro biochemical assay using scavenger decapping enzyme (DcpS) as a target and cell based assay using SMN2 b-lactamase NSC-34 cell reporter gene.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232589(5-((3-chlorophenoxy)methyl)quinazoline-2,4-diamine...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232538(D156844 | CHEMBL251429 | 5-((1-(2-fluorobenzyl)pip...)
Affinity DataIC50: 9.38E+3nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232526(5-((2,4-difluorophenoxy)methyl)quinazoline-2,4-dia...)
Affinity DataIC50: 1.07E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232527(5-((1-(3-chlorobenzyl)piperidin-4-yl)methoxy)quina...)
Affinity DataIC50: 5.52E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232566(5-(3-chlorobenzyloxy)quinazoline-2,4-diamine | CHE...)
Affinity DataIC50: 9.80E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232561(5-((1-(2-fluorophenylsulfonyl)piperidin-4-yl)metho...)
Affinity DataIC50: 1.25E+5nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232571((2-chlorophenyl)(4-((2,4-diaminoquinazolin-5-yloxy...)
Affinity DataIC50: 1.25E+5nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232538(D156844 | CHEMBL251429 | 5-((1-(2-fluorobenzyl)pip...)
Affinity DataIC50: 1.25E+5nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232541((3-chlorophenyl)(4-((2,4-diaminoquinazolin-5-yloxy...)
Affinity DataIC50: 1.25E+5nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed