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Report error Found 256 with Last Name = 'tripp' and Initial = 'ae'
LigandPNGBDBM50145719((S)-3-{4-[2-(2-Cyclohexyl-5-methyl-oxazol-4-yl)-et...)
Affinity DataEC50:  1nMAssay Description:Transcriptional activation of reporter assay by PPAR gamma receptor in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50145719((S)-3-{4-[2-(2-Cyclohexyl-5-methyl-oxazol-4-yl)-et...)
Affinity DataEC50:  1nMAssay Description:Transcriptional activation of reporter assay by human Peroxisome proliferator activated receptor alpha in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 3(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50558766(CHEMBL4751065)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50558766(CHEMBL4751065)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at human recombinant mGlu3 stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50204261(CHEMBL3969063)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]-LY459477 from human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing human EAAT1 after 90 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-...)
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at human recombinant mGlu3 stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50145722((S)-2-Methyl-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-y...)
Affinity DataEC50:  3nMAssay Description:Transcriptional activation of reporter assay by PPAR gamma receptor in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50145721((S)-2-Methyl-3-{4-[2-(5-methyl-2-thiophen-2-yl-oxa...)
Affinity DataEC50:  4nMAssay Description:Transcriptional activation of reporter assay by PPAR gamma receptor in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50558766(CHEMBL4751065)
Affinity DataIC50: 4.10nMAssay Description:Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as asse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 2(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu2 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 3(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50558768(CHEMBL4759992)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandPNGBDBM50145722((S)-2-Methyl-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-y...)
Affinity DataEC50:  5nMAssay Description:Transcriptional activation of reporter assay by human Peroxisome proliferator activated receptor alpha in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50145722((S)-2-Methyl-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-y...)
Affinity DataEC50:  5nMAssay Description:Transactivation activity for human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50558768(CHEMBL4759992)
Affinity DataKi:  5.20nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu2 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50558766(CHEMBL4751065)
Affinity DataKi:  5.30nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu2 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 3(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50558774(CHEMBL4780402)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandPNGBDBM50145723(3-{4-[2-(2-Biphenyl-3-yl-5-methyl-oxazol-4-yl)-eth...)
Affinity DataEC50:  6nMAssay Description:Transcriptional activation of reporter assay by PPAR gamma receptor in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50145710(2-Methyl-3-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-...)
Affinity DataEC50:  6nMAssay Description:Transcriptional activation of reporter assay by PPAR gamma receptor in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50558766(CHEMBL4751065)
Affinity DataIC50: 6.20nMAssay Description:Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50434133(CHEMBL2381643)
Affinity DataIC50: 6.30nMAssay Description:Agonist activity at mGlu3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50558768(CHEMBL4759992)
Affinity DataIC50: 6.60nMAssay Description:Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50558775(CHEMBL4776989)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandPNGBDBM50145723(3-{4-[2-(2-Biphenyl-3-yl-5-methyl-oxazol-4-yl)-eth...)
Affinity DataEC50:  7nMAssay Description:Transactivation activity for human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50056272((2S,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxy...)
Affinity DataIC50: 7nMAssay Description:Agonist activity at mGlu2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50145714(3-{4-[2-(2-Biphenyl-4-yl-5-methyl-oxazol-4-yl)-eth...)
Affinity DataEC50:  7nMAssay Description:Transcriptional activation of reporter assay by PPAR gamma receptor in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50145723(3-{4-[2-(2-Biphenyl-3-yl-5-methyl-oxazol-4-yl)-eth...)
Affinity DataEC50:  7nMAssay Description:Transcriptional activation of reporter assay by human Peroxisome proliferator activated receptor alpha in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50156525(2-Methyl-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-e...)
Affinity DataEC50:  7nMAssay Description:Transactivation activity for human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50204261(CHEMBL3969063)
Affinity DataKi:  7.40nMAssay Description:Displacement of [3H]-LY459477 from human mGlu2 receptor expressed in hamster AV12 cell membranes co-expressing human EAAT1 after 90 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-...)
Affinity DataIC50: 7.70nMAssay Description:Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 3(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50558769(CHEMBL4746125)
Affinity DataKi:  7.70nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-...)
Affinity DataIC50: 7.80nMAssay Description:Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as asse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50145712(2-Methyl-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-e...)
Affinity DataEC50:  8nMAssay Description:Transcriptional activation of reporter assay by PPAR gamma receptor in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50558772(CHEMBL4748699)
Affinity DataKi:  8.40nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu2 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50434132(CHEMBL2381642)
Affinity DataIC50: 8.60nMAssay Description:Agonist activity at mGlu2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50558774(CHEMBL4780402)
Affinity DataKi:  8.90nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu2 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandPNGBDBM50145718(3-{4-[2-(2-Cyclohexyl-5-methyl-oxazol-4-yl)-ethoxy...)
Affinity DataEC50:  9nMAssay Description:Transcriptional activation of reporter assay by PPAR gamma receptor in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50145721((S)-2-Methyl-3-{4-[2-(5-methyl-2-thiophen-2-yl-oxa...)
Affinity DataEC50:  9nMAssay Description:Transcriptional activation of reporter assay by human Peroxisome proliferator activated receptor alpha in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50558769(CHEMBL4746125)
Affinity DataKi:  9.20nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu2 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50558772(CHEMBL4748699)
Affinity DataKi:  9.40nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50558772(CHEMBL4748699)
Affinity DataIC50: 9.80nMAssay Description:Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50558775(CHEMBL4776989)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu2 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandPNGBDBM50145721((S)-2-Methyl-3-{4-[2-(5-methyl-2-thiophen-2-yl-oxa...)
Affinity DataIC50: 10nMAssay Description:Displacement of PPARgamma agonist from human PPAR gamma receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50156527(2-(4-tert-Butyl-phenoxy)-2-methyl-3-{4-[2-(5-methy...)
Affinity DataEC50:  11nMAssay Description:Transactivation activity for human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50434132(CHEMBL2381642)
Affinity DataIC50: 11nMAssay Description:Agonist activity at mGlu3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandPNGBDBM50145712(2-Methyl-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-e...)
Affinity DataEC50:  12nMAssay Description:Transcriptional activation of reporter assay by human Peroxisome proliferator activated receptor alpha in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50558769(CHEMBL4746125)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandPNGBDBM50145712(2-Methyl-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-e...)
Affinity DataEC50:  12nMAssay Description:Transactivation activity for human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50204261(CHEMBL3969063)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at recombinant human mGlu2 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Centro De Investigaci£N Lilly S.A. Avda. De La Industria

Curated by ChEMBL
LigandPNGBDBM50558778(CHEMBL4778355)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
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