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TargetAcidic mammalian chitinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50378795(CHEMBL1215473)
Affinity DataKd:  1.69E+3nMAssay Description:Binding affinity to biotinylated-acidic mammalian chitinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAcidic mammalian chitinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50378796(CHEMBL1215544)
Affinity DataKd:  1.70E+4nMAssay Description:Binding affinity to biotinylated-acidic mammalian chitinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcidic mammalian chitinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50027028(2-(piperazin-1-yl)nicotinamide | 2-Piperazin-1-yl-...)
Affinity DataKd:  1.41E+5nMAssay Description:Binding affinity to biotinylated-acidic mammalian chitinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50201921(2-Biphenyl-4-yl-6-fluoro-3-hydroxy-quinoline-4-car...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50: 5nMAssay Description:Inhibition of Abl 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50: 5nMAssay Description:Inhibition of FynMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50: 5nMAssay Description:Inhibition of src kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50201923(3-hydroxy-2-(4'-hydroxy-biphenyl-4-yl)-quinoline-4...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50201945(6-fluoro-3-hydroxy-2-(4-phenoxyphenyl)quinoline-4-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50201905(3-hydroxy-2-(4-phenoxyphenyl)quinoline-4-carboxyli...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50201919(6-fluoro-3-hydroxy-2-(4'-hydroxy-biphenyl-4-yl)-qu...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50201925(2-BIPHENYL-4-YL-6-FLUORO-3-METHYL-QUINOLINE-4-CARB...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50201949(2-biphenyl-4-yl-3-hydroxy-quinoline-4-carboxylic a...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50201918(3-amino-2-biphenyl-4-yl-6-fluoro-quinoline-4-carbo...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50: 16nMAssay Description:Inhibition of HckMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50201939(6-fluoro-3-hydroxy-2-(4-(phenylthio)phenyl)quinoli...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50: 24nMAssay Description:Inhibition of GCKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50: 35nMAssay Description:Inhibition of LCK by LANCE FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50: 38nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Wyeth Research

LigandPNGBDBM25553(4-[(2,4-dichlorophenyl)amino]-5-(3,4-dimethoxyphen...)
Affinity DataIC50: 80nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Wyeth Research

LigandPNGBDBM25554(5-(3,4-dimethoxyphenyl)-4-[(2,4-dimethylphenyl)ami...)
Affinity DataIC50: 160nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcidic mammalian chitinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50378795(CHEMBL1215473)
Affinity DataIC50: 210nMAssay Description:Inhibition of acidic mammalian chitinase after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50201900(6-bromo-2-(4-chlorophenyl)-3-hydroxyquinoline-4-ca...)
Affinity DataIC50: 211nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50201940(2-(4-chlorophenyl)-3-hydroxy-6-methylquinoline-4-c...)
Affinity DataIC50: 217nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50201913(2-(4-chlorophenyl)-3-hydroxy-6-(trifluoromethyl)qu...)
Affinity DataIC50: 270nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50201934(2-(4-chlorophenyl)-6-fluoro-3-hydroxyquinoline-4-c...)
Affinity DataIC50: 312nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Wyeth Research

LigandPNGBDBM25551(5-(3,4-dimethoxyphenyl)-4-[(4-methoxyphenyl)amino]...)
Affinity DataIC50: 400nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Wyeth Research

LigandPNGBDBM25555(4-[(2,5-dichlorophenyl)amino]-5-(3,4-dimethoxyphen...)
Affinity DataIC50: 470nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcidic mammalian chitinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM72759(MLS000860449 | 2-methyl-3-[(4-pyridin-2-ylpiperazi...)
Affinity DataIC50: 700nMAssay Description:Inhibition of acidic mammalian chitinase after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProtein kinase C theta type(Human)
Wyeth Research

LigandPNGBDBM25550(5-(3,4-dimethoxyphenyl)-4-[(4-methylphenyl)amino]p...)
Affinity DataIC50: 900nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201902(2-(4-chlorophenyl)-3-hydroxy-7,8-dimethylquinoline...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Wyeth Research

LigandPNGBDBM25546(5-(3,4-dimethoxyphenyl)-4-[(3-fluorophenyl)amino]p...)
Affinity DataIC50: 1.40E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Wyeth Research

LigandPNGBDBM25544(5-(3,4-dimethoxyphenyl)-4-(phenylamino)pyridine-3-...)
Affinity DataIC50: 1.60E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Wyeth Research

LigandPNGBDBM25560(4-(2,3-dihydro-1H-inden-5-ylamino)-5-(3,4-dimethox...)
Affinity DataIC50: 2.00E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201902(2-(4-chlorophenyl)-3-hydroxy-7,8-dimethylquinoline...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50201930(6-fluoro-3-hydroxy-2-(4-hydroxyphenyl)quinoline-4-...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Wyeth Research

LigandPNGBDBM25557(5-(3,4-dimethoxyphenyl)-4-[(3,4-dimethoxyphenyl)am...)
Affinity DataIC50: 2.20E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Wyeth Research

LigandPNGBDBM25559(CHEMBL492252 | 5-(3,4-dimethoxyphenyl)-4-(1H-indol...)
Affinity DataIC50: 2.20E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Wyeth Research

LigandPNGBDBM25556(4-[(3,4-dichlorophenyl)amino]-5-(3,4-dimethoxyphen...)
Affinity DataIC50: 2.40E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Wyeth Research

LigandPNGBDBM25549(4-[(4-chlorophenyl)amino]-5-(3,4-dimethoxyphenyl)p...)
Affinity DataIC50: 2.80E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Wyeth Research

LigandPNGBDBM25545(4-[(3-chlorophenyl)amino]-5-(3,4-dimethoxyphenyl)p...)
Affinity DataIC50: 3.90E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201902(2-(4-chlorophenyl)-3-hydroxy-7,8-dimethylquinoline...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50201892(2-(4-chlorophenyl)-3-hydroxy-6-(trifluoromethoxy)q...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201901(2-(4-chlorophenyl)-3-hydroxy-8-phenylquinoline-4-c...)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human CYP2C8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50201920(2-(4-chlorophenyl)-3-hydroxy-6,8-dimethylquinoline...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201902(2-(4-chlorophenyl)-3-hydroxy-7,8-dimethylquinoline...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50201901(2-(4-chlorophenyl)-3-hydroxy-8-phenylquinoline-4-c...)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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