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TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiled plasmid DNA formation after 30 mins by electrophoretic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetDNA topoisomerase 2-alpha(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259245(CHEMBL4064127 | US10266550, Compound 17a)
Affinity DataIC50:  970nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259244(CHEMBL4076393 | US10266550, Compound 16)
Affinity DataIC50:  1.95E+3nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259215(CHEMBL4064887 | US10266550, Compound 11b)
Affinity DataIC50:  1.95E+3nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259247(CHEMBL4065223 | US10266550, Compound 11g)
Affinity DataIC50:  1.95E+3nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259242(CHEMBL4072011 | US10266550, Compound 11e)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259214(CHEMBL4061346 | US10266550, Compound 11a)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259248(CHEMBL4104625 | US10266550, Compound 17bbSelectivi...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
University of Cagliari

Curated by ChEMBL
LigandPNGBDBM50358566(UNGEREMINE)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of human topoisomerase 1-mediated relaxation of supercoiled pBR322 DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Yersinia pestis)
University of Hawai'I At Hilo

Curated by ChEMBL
LigandPNGBDBM50496611(CHEMBL3134416)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of Yersinia pestis topoisomerase 1-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Yersinia pestis)
University of Hawai'I At Hilo

Curated by ChEMBL
LigandPNGBDBM50496611(CHEMBL3134416)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of Yersinia pestis topoisomerase 1-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259221(CHEMBL4097472 | US10266550, Compound 11d)
Affinity DataIC50:  1.56E+4nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50358566(UNGEREMINE)
Affinity DataIC50:  2.58E+4nMAssay Description:Inhibition of human topoisomerase 2alpha-mediated relaxation of supercoiled pBR322 DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50496611(CHEMBL3134416)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50496611(CHEMBL3134416)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
University of Cagliari

Curated by ChEMBL
LigandPNGBDBM50239538(CHEMBL3953305)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human DNA topoisomerase 1 using plasmid pBAD-GFPuv as substrate after 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
University of Cagliari

Curated by ChEMBL
LigandPNGBDBM50239536(CHEMBL3902093)
Affinity DataIC50: >5.00E+4nMAssay Description:Binding affinity to adenosine A1 receptor of rat brain membranes without NaCl by inhibition of [125-I]-labeled aminobenzyl adenosine bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
University of Cagliari

Curated by ChEMBL
LigandPNGBDBM50239535(CHEMBL3973119)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human DNA topoisomerase 1 using plasmid pBAD-GFPuv as substrate after 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
University of Cagliari

Curated by ChEMBL
LigandPNGBDBM50239534(CHEMBL4098769)
Affinity DataIC50: >5.00E+4nMAssay Description:Binding affinity towards adenosine A1 receptor of rat brain membranes with 1 M NaCl by inhibition of [125-I]-labeled aminobenzyl adenosine binding More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Human)
University of Cagliari

Curated by ChEMBL
LigandPNGBDBM50239537(CHEMBL3981132)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human DNA topoisomerase 1 using plasmid pBAD-GFPuv as substrate after 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Yersinia pestis)
University of Hawai'I At Hilo

Curated by ChEMBL
LigandPNGBDBM50496604(CHEMBL3134406)
Affinity DataIC50:  6.25E+4nMAssay Description:Inhibition of Yersinia pestis topoisomerase 1-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM21691(1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridi...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiled plasmid DNA formation after 30 mins by electrophoretic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50496617(CHEMBL3134419)
Affinity DataIC50:  1.25E+5nMAssay Description:Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Yersinia pestis)
University of Hawai'I At Hilo

Curated by ChEMBL
LigandPNGBDBM50496622(CHEBI:34640 | CHEMBL1739417)
Affinity DataIC50:  1.25E+5nMAssay Description:Inhibition of Yersinia pestis topoisomerase 1-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259213(CHEMBL4079855 | US10266550, Compound 7e)
Affinity DataIC50:  1.25E+5nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259246(CHEMBL4066307 | US10266550, Compound 10a)
Affinity DataIC50:  2.50E+5nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50027668(CHEMBL3357531)
Affinity DataIC50:  2.50E+5nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiled plasmid DNA formation after 30 mins by electrophoretic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Yersinia pestis)
University of Hawai'I At Hilo

Curated by ChEMBL
LigandPNGBDBM50496605(CHEMBL3134411)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of Yersinia pestis topoisomerase 1-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Yersinia pestis)
University of Hawai'I At Hilo

Curated by ChEMBL
LigandPNGBDBM50496621(CHEMBL3134405)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of Yersinia pestis topoisomerase 1-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Yersinia pestis)
University of Hawai'I At Hilo

Curated by ChEMBL
LigandPNGBDBM50496620(CHEMBL3134413)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of Yersinia pestis topoisomerase 1-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Yersinia pestis)
University of Hawai'I At Hilo

Curated by ChEMBL
LigandPNGBDBM50496619(CHEMBL3134412)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of Yersinia pestis topoisomerase 1-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50496609(CHEMBL3134418)
Affinity DataIC50:  2.50E+5nMAssay Description:Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Yersinia pestis)
University of Hawai'I At Hilo

Curated by ChEMBL
LigandPNGBDBM50496618(CHEMBL3134408)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of Yersinia pestis topoisomerase 1-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Yersinia pestis)
University of Hawai'I At Hilo

Curated by ChEMBL
LigandPNGBDBM50496617(CHEMBL3134419)
Affinity DataIC50:  2.50E+5nMAssay Description:Inhibition of Yersinia pestis topoisomerase 1-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50496614(CHEMBL3134421)
Affinity DataIC50:  2.50E+5nMAssay Description:Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Yersinia pestis)
University of Hawai'I At Hilo

Curated by ChEMBL
LigandPNGBDBM50496612(CHEMBL3134410)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of Yersinia pestis topoisomerase 1-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Yersinia pestis)
University of Hawai'I At Hilo

Curated by ChEMBL
LigandPNGBDBM50052414(4-(1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthale...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of Yersinia pestis topoisomerase 1-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Yersinia pestis)
University of Hawai'I At Hilo

Curated by ChEMBL
LigandPNGBDBM50061625(4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthal...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of Yersinia pestis topoisomerase 1-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Yersinia pestis)
University of Hawai'I At Hilo

Curated by ChEMBL
LigandPNGBDBM50496607(CHEMBL3134407)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of Yersinia pestis topoisomerase 1-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Yersinia pestis)
University of Hawai'I At Hilo

Curated by ChEMBL
LigandPNGBDBM50496606(CHEMBL3134409)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of Yersinia pestis topoisomerase 1-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50027673(Olympicin A)
Affinity DataIC50:  5.00E+5nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiled plasmid DNA formation after 30 mins by electrophoretic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50027665((E)-1-(2,4-dihydroxyphenyl)-3-(2-allyloxyphenyl)-2...)
Affinity DataIC50:  5.00E+5nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiled plasmid DNA formation after 30 mins by electrophoretic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259212(CHEMBL2002459 | US10266550, Compound 1)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Yersinia pestis)
University of Hawai'I At Hilo

Curated by ChEMBL
LigandPNGBDBM50496609(CHEMBL3134418)
Affinity DataIC50:  5.00E+5nMAssay Description:Inhibition of Yersinia pestis topoisomerase 1-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50496613(CHEMBL3134404)
Affinity DataIC50:  5.00E+5nMAssay Description:Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Yersinia pestis)
University of Hawai'I At Hilo

Curated by ChEMBL
LigandPNGBDBM50496614(CHEMBL3134421)
Affinity DataIC50:  5.00E+5nMAssay Description:Inhibition of Yersinia pestis topoisomerase 1-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 1(Yersinia pestis)
University of Hawai'I At Hilo

Curated by ChEMBL
LigandPNGBDBM50496615(CHEMBL3134417)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of Yersinia pestis topoisomerase 1-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50027670(CHEMBL3357527)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiled plasmid DNA formation after 30 mins by electrophoretic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50496610(CHEMBL3134420)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetDNA topoisomerase 2-alpha(Human)
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50496608(CHEBI:66955 | CHEMBL3134414)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled plasmid DNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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