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TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataEC50:  0.0220nMAssay Description:Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaS...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103443(US8552037, 90)
Affinity DataEC50:  0.0150nMAssay Description:Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataEC50:  0.850nMAssay Description:Agonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaS...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103443(US8552037, 90)
Affinity DataEC50:  0.510nMAssay Description:Agonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataEC50:  0.0260nMAssay Description:Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50347588(CHEMBL1802025)
Affinity DataEC50:  0.530nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataEC50:  0.820nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50347588(CHEMBL1802025)
Affinity DataEC50:  0.0210nMAssay Description:Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50025190(CHEMBL3337899)
Affinity DataIC50: 0.00220nMAssay Description:Inhibition of human recombinant MMP13 catalytic domain using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50203953(CHEMBL3932562)
Affinity DataIC50: 0.00320nMAssay Description:Inhibition of recombinant human AMPA-activated MMP13 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50102750(CHEMBL3359091)
Affinity DataIC50: 0.00390nMAssay Description:Inhibition of human recombinant MMP13 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50102750(CHEMBL3359091)
Affinity DataIC50: 0.00390nMAssay Description:Inhibition of recombinant human AMPA-activated MMP13 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50025188(CHEMBL3337897)
Affinity DataIC50: 0.00500nMAssay Description:Inhibition of human recombinant MMP13 catalytic domain using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50025160(CHEMBL3337894)
Affinity DataIC50: 0.00690nMAssay Description:Inhibition of human recombinant MMP13 catalytic domain using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50025192(CHEMBL3337901)
Affinity DataIC50: 0.00770nMAssay Description:Inhibition of human recombinant MMP13 catalytic domain using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM11863(CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human recombinant MMP13 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM11863(CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of recombinant human AMPA-activated MMP13 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM11863(CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of APMA-activated recombinant human MMP-13 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50025184(CHEMBL3337892)
Affinity DataIC50: 0.0150nMAssay Description:Inhibition of human recombinant MMP13 catalytic domain using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50025183(CHEMBL3337891)
Affinity DataIC50: 0.0180nMAssay Description:Inhibition of human recombinant MMP13 catalytic domain using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50025189(CHEMBL3337898)
Affinity DataIC50: 0.0180nMAssay Description:Inhibition of human recombinant MMP13 catalytic domain using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50025194(CHEMBL3337903)
Affinity DataIC50: 0.0210nMAssay Description:Inhibition of human recombinant MMP13 catalytic domain using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103448(US8552037, 95)
Affinity DataIC50: 0.0220nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50233896(CHEMBL4087855)
Affinity DataIC50: 0.0240nMAssay Description:Inhibition of APMA-activated recombinant human MMP-13 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50025191(CHEMBL3337900)
Affinity DataIC50: 0.0260nMAssay Description:Inhibition of human recombinant MMP13 catalytic domain using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50233883(CHEMBL4094620)
Affinity DataIC50: 0.0260nMAssay Description:Inhibition of APMA-activated recombinant human MMP-13 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50233894(CHEMBL4079123)
Affinity DataIC50: 0.0270nMAssay Description:Inhibition of APMA-activated recombinant human MMP-13 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50025187(CHEMBL3337896)
Affinity DataIC50: 0.0280nMAssay Description:Inhibition of human recombinant MMP13 catalytic domain using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target72 kDa type IV collagenase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM11863(CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...)
Affinity DataIC50: 0.0290nMAssay Description:Inhibition of human recombinant MMP2 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50025185(CHEMBL3337893)
Affinity DataIC50: 0.0290nMAssay Description:Inhibition of human recombinant MMP13 catalytic domain using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target72 kDa type IV collagenase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM11863(CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...)
Affinity DataIC50: 0.0290nMAssay Description:Inhibition of human recombinant MMP2 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target72 kDa type IV collagenase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM11863(CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...)
Affinity DataIC50: 0.0290nMAssay Description:Inhibition of recombinant human AMPA-activated MMP2 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target72 kDa type IV collagenase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM11863(CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...)
Affinity DataIC50: 0.0290nMAssay Description:Inhibition of APMA-activated recombinant human MMP-2 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103446(US8552037, 93)
Affinity DataIC50: 0.0300nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50102751(CHEMBL3359090)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human recombinant MMP13 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50025181(CHEMBL3337889)
Affinity DataIC50: 0.0320nMAssay Description:Inhibition of human recombinant MMP13 catalytic domain using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50233888(CHEMBL4092215)
Affinity DataIC50: 0.0330nMAssay Description:Inhibition of APMA-activated recombinant human MMP-13 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50233878(CHEMBL4059519)
Affinity DataIC50: 0.0340nMAssay Description:Inhibition of APMA-activated recombinant human MMP-13 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50233877(CHEMBL4068176)
Affinity DataIC50: 0.0360nMAssay Description:Inhibition of APMA-activated recombinant human MMP-13 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103450(US8552037, 98)
Affinity DataIC50: 0.0380nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50102753(CHEMBL3359088)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of human recombinant MMP13 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50233895(CHEMBL4103367)
Affinity DataIC50: 0.0430nMAssay Description:Inhibition of APMA-activated recombinant human MMP-13 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103446(US8552037, 93)
Affinity DataIC50: 0.0490nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50204002(CHEMBL3889936)
Affinity DataIC50: 0.0510nMAssay Description:Inhibition of recombinant human AMPA-activated MMP13 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50203961(CHEMBL3958969)
Affinity DataIC50: 0.0520nMAssay Description:Inhibition of recombinant human AMPA-activated MMP13 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50025193(CHEMBL3337902)
Affinity DataIC50: 0.0530nMAssay Description:Inhibition of human recombinant MMP13 catalytic domain using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50233880(CHEMBL4090287)
Affinity DataIC50: 0.0540nMAssay Description:Inhibition of APMA-activated recombinant human MMP-13 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM103443(US8552037, 90)
Affinity DataIC50: 0.0570nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50233901(CHEMBL4069240)
Affinity DataIC50: 0.0570nMAssay Description:Inhibition of APMA-activated recombinant human MMP-13 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50233886(CHEMBL4078492)
Affinity DataIC50: 0.0590nMAssay Description:Inhibition of APMA-activated recombinant human MMP-13 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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