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TargetHematopoietic prostaglandin D synthase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50526485(CHEMBL4473072)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) by tryptophan fluorescence quenching assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50573153(CHEMBL4877995)
Affinity DataIC50: 0nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573157(CHEMBL4850297)
Affinity DataIC50: 0.316nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573166(CHEMBL4869783)
Affinity DataIC50: 0.398nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573167(CHEMBL4858875)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573177(CHEMBL4167702)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573181(CHEMBL4165185)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573182(CHEMBL4175571)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573180(CHEMBL4175737)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573164(CHEMBL4873390)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573174(CHEMBL4868232)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573175(CHEMBL4169192)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573167(CHEMBL4858875)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573176(CHEMBL4173087)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573178(CHEMBL4170075)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573179(CHEMBL4174874)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573155(CHEMBL4872328)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PI3Kdelta in human HL-60 cell extract measured after 2 hrs by kinobeads based chemoproteomic competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50573163(CHEMBL4870020)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573170(CHEMBL4855234)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573182(CHEMBL4175571)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573158(CHEMBL4869356)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573159(CHEMBL4867203)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573168(CHEMBL4845674)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573173(CHEMBL4870970)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573176(CHEMBL4173087)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573178(CHEMBL4170075)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573174(CHEMBL4868232)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50521218(CHEMBL4434674)
Affinity DataIC50: 4nMAssay Description:Inhibition of PI3Kdelta in human PBMC assessed as reduction in cytostim-induced IFNgamma production after 20 hrs by electrochemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573156(CHEMBL4878870)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536411(CHEMBL4564931)
Affinity DataIC50: 5nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573160(CHEMBL4868553)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573161(CHEMBL4863100)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573155(CHEMBL4872328)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50573162(CHEMBL4872822)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573177(CHEMBL4167702)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536416(CHEMBL4522825)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573165(CHEMBL4846241)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573180(CHEMBL4175737)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573181(CHEMBL4165185)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50526494(CHEMBL4439454)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50526495(CHEMBL4452633)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50526485(CHEMBL4473072)
Affinity DataIC50: 9.90nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50573179(CHEMBL4174874)
Affinity DataIC50: 10nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50536417(CHEMBL4592637)
Affinity DataIC50: 13nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573172(CHEMBL4870356)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573157(CHEMBL4850297)
Affinity DataIC50: 13nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573159(CHEMBL4867203)
Affinity DataIC50: 13nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573175(CHEMBL4169192)
Affinity DataIC50: 13nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50526492(CHEMBL4454901)
Affinity DataIC50: 14nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50526486(CHEMBL4526974)
Affinity DataIC50: 15nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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