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TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  2.30nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 0.5 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195695(CHEMBL3941037)
Affinity DataKd:  6.5nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  0.740nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  0.740nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs at room temperature by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195695(CHEMBL3941037)
Affinity DataKd:  8.10nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 0.5 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195695(CHEMBL3941037)
Affinity DataKd:  6nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  0.490nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195695(CHEMBL3941037)
Affinity DataKd:  10nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  0.340nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs at 37 degC by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  23nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs at 4 degC by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
Japan Biological Informatics Consortium (Jbic)

Curated by ChEMBL
LigandPNGBDBM82258(NSC_3961 | CAS_114798-26-4 | Losartan)
Affinity DataKd:  1.70E+5nMAssay Description:Binding affinity to human N-terminal Ig-like domain D1D2 GPVI expressed in Escherichia coli DH5alpha by NMR spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataIC50: 0.160nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cell membranes pretreated for 24 hrs prior to Fura-2-AM dye addition for 1 hr followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataIC50: 0.190nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cell membranes pretreated for 24 hrs prior to Fura-2-AM dye addition for 1 hr followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50101813(CHEBI:31399 | Cilnidipine)
Affinity DataIC50: 1.10nMAssay Description:Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042977(1-(2,5-Diethoxy-phenyl)-3-(3,4-dihydroxy-phenyl)-p...)
Affinity DataIC50: 2.40nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50475660(CHEMBL201566)
Affinity DataIC50: 2.80nMAssay Description:Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM149705(US8975409, Example 9(3))
Affinity DataIC50: 3.30nMAssay Description:Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195700(CHEMBL3975893)
Affinity DataIC50: 3.5nMAssay Description:Antagonist activity at human LPA1 receptor expressed in CHO cells assessed as reduction in LPA-induced intracellular Ca2+ concentration pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2018
Entry Details Article
PubMed
LigandPNGBDBM50475658(CHEMBL201984)
Affinity DataIC50: 3.70nMAssay Description:Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50065611(CHEMBL3401383)
Affinity DataIC50: 3.70nMAssay Description:Displacement of [33P]S1P from human S1P2 expressed in CHO-K1 cells by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042951(3-(3,4-Dihydroxy-phenyl)-1-(5-ethoxy-2-methoxy-phe...)
Affinity DataIC50: 3.80nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042962(3-(3,4-Dihydroxy-phenyl)-1-(4-hydroxy-phenyl)-prop...)
Affinity DataIC50: 4nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042981(3-(3,4-Dihydroxy-phenyl)-1-(2-hydroxy-5-isopropyl-...)
Affinity DataIC50: 4nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042979(3-(3,4-Dihydroxy-phenyl)-1-(3-hydroxy-phenyl)-prop...)
Affinity DataIC50: 4.20nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042949((E)-3-(3,4-Dihydroxy-phenyl)-1-(2,4-dihydroxy-phen...)
Affinity DataIC50: 4.60nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50120582(CHEMBL3618199)
Affinity DataIC50: 4.60nMAssay Description:Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042964(3-(3,4-Dihydroxy-phenyl)-1-(4-dimethylamino-phenyl...)
Affinity DataIC50: 4.70nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50065611(CHEMBL3401383)
Affinity DataIC50: 4.80nMAssay Description:Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042971(3-(3,4-Dihydroxy-phenyl)-1-(5-ethoxy-2-hydroxy-phe...)
Affinity DataIC50: 5.30nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50475653(CHEMBL382528)
Affinity DataIC50: 5.80nMAssay Description:Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50120583(CHEMBL3618200)
Affinity DataIC50: 5.80nMAssay Description:Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195694(CHEMBL3976876)
Affinity DataIC50: 5.90nMAssay Description:Antagonist activity at human LPA1 receptor expressed in CHO cells assessed as reduction in LPA-induced intracellular Ca2+ concentration pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2018
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM149705(US8975409, Example 9(3))
Affinity DataIC50: 6.20nMAssay Description:Antagonist activity at human S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042945(3-(3,4-Dihydroxy-phenyl)-1-(3-methoxy-phenyl)-prop...)
Affinity DataIC50: 6.5nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50475650(CHEMBL203041)
Affinity DataIC50: 6.80nMAssay Description:Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50004679(CHEMBL85000 | 2-Benzyl-naphthalen-1-ol | 2-Benzyl-...)
Affinity DataIC50: 6.90nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042968(3-(3,4-Dihydroxy-phenyl)-1-(2,5-dimethoxy-phenyl)-...)
Affinity DataIC50: 7.80nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042973(1-(4-chlorophenyl)-3-(3,4-dihydroxyphenyl)prop-2-e...)
Affinity DataIC50: 8.5nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50475663(CHEMBL202464)
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042991(3-(3,4-Dihydroxy-phenyl)-1-(4-hydroxy-3-methoxy-ph...)
Affinity DataIC50: 9nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042960(3-(3,4-Dihydroxy-phenyl)-1-(3-dimethylamino-phenyl...)
Affinity DataIC50: 9.80nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50475664(CHEMBL369934)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042950(3-(3,4-dihydroxyphenyl)-1-(2,4-dimethoxyphenyl)pro...)
Affinity DataIC50: 10nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042952(3-(3,4-Dihydroxy-phenyl)-1-(2-hydroxy-5-isopropoxy...)
Affinity DataIC50: 11nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285789(CHEMBL4169559)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cells assessed as reduction in LPA-induced intracellular calcium level pretreated foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50475672(CHEMBL201057)
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50120579(CHEMBL3618196)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
LigandPNGBDBM50475662(CHEMBL201860)
Affinity DataIC50: 14nMAssay Description:Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042953(3-(3,4-Dihydroxy-phenyl)-1-(5-isopropoxy-2-methoxy...)
Affinity DataIC50: 14nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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