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TargetNeuromedin-K receptor(Guinea pig)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM85845(N-[(S)-1-Phenylpropyl]-2-phenyl-3-(carboxymethoxy)...)
Affinity DataKi:  1.60nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Human)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM85845(N-[(S)-1-Phenylpropyl]-2-phenyl-3-(carboxymethoxy)...)
Affinity DataKi:  2.20nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Mouse)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM85845(N-[(S)-1-Phenylpropyl]-2-phenyl-3-(carboxymethoxy)...)
Affinity DataKi:  17.9nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Mouse)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM85845(N-[(S)-1-Phenylpropyl]-2-phenyl-3-(carboxymethoxy)...)
Affinity DataKi:  82.4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Rat)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM85845(N-[(S)-1-Phenylpropyl]-2-phenyl-3-(carboxymethoxy)...)
Affinity DataKi:  2.33E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Rat)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM85845(N-[(S)-1-Phenylpropyl]-2-phenyl-3-(carboxymethoxy)...)
Affinity DataKi:  5.25E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Guinea pig)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM85845(N-[(S)-1-Phenylpropyl]-2-phenyl-3-(carboxymethoxy)...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472190(CHEMBL167638)
Affinity DataIC50:  5nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50042058((-)-rolipram | (4R)-4-[3-(cyclopentyloxy)-4-methox...)
Affinity DataIC50:  5nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50280333(CHEMBL49207 | [4,4-Diethyl-6-oxo-1-[2'-(1H-tetrazo...)
Affinity DataIC50:  20nMAssay Description:Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472191(CHEMBL167166)
Affinity DataIC50:  40nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50280320(CHEMBL51084 | [4-Oxo-3-[2'-(1H-tetrazol-5-yl)-biph...)
Affinity DataIC50:  40nMAssay Description:Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472193(CHEMBL352628)
Affinity DataIC50:  44nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50042056((R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolid...)
Affinity DataIC50:  45nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472187(CHEMBL169746)
Affinity DataIC50:  45nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472198(CHEMBL354447)
Affinity DataIC50:  52nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50281522(CHEMBL121871 | [3-Oxo-2-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataIC50:  60nMAssay Description:Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex mem...More data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50281520(CHEMBL123348 | [3-Ethyl-3-methyl-5-oxo-1-[2'-(1H-t...)
Affinity DataIC50:  60nMAssay Description:Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex mem...More data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472189(CHEMBL167486)
Affinity DataIC50:  70nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472199(CHEMBL169537)
Affinity DataIC50:  80nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50280325(CHEMBL48459 | [4-Ethyl-6-oxo-4-propyl-1-[2'-(1H-te...)
Affinity DataIC50:  90nMAssay Description:Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50:  95nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50:  95nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50281524(CHEMBL123713 | [3,3-Diethyl-5-oxo-1-[2'-(1H-tetraz...)
Affinity DataIC50:  100nMAssay Description:Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex mem...More data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472197(CHEMBL352857)
Affinity DataIC50:  110nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50280321(CHEMBL296731 | [4-Isopropyl-4-methyl-6-oxo-1-[2'-(...)
Affinity DataIC50:  120nMAssay Description:Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472192(CHEMBL167258)
Affinity DataIC50:  120nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50:  120nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50:  120nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472189(CHEMBL167486)
Affinity DataIC50:  120nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472193(CHEMBL352628)
Affinity DataIC50:  120nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50280329(CHEMBL50906 | [4-Methyl-6-oxo-4-propyl-1-[2'-(1H-t...)
Affinity DataIC50:  120nMAssay Description:Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50281519(CHEMBL124449 | [3-Oxo-2-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataIC50:  140nMAssay Description:Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex mem...More data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50280323(CHEMBL51622 | [4-Butyl-4-ethyl-6-oxo-1-[2'-(1H-tet...)
Affinity DataIC50:  180nMAssay Description:Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472191(CHEMBL167166)
Affinity DataIC50:  195nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50280322(CHEMBL413098 | [4-Methyl-6-oxo-1-[2'-(1H-tetrazol-...)
Affinity DataIC50:  200nMAssay Description:Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50280328(CHEMBL418269 | [4,4-Diethyl-6-oxo-1-[2'-(1H-tetraz...)
Affinity DataIC50:  210nMAssay Description:Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50281523(CHEMBL421094 | [3-Oxo-2-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataIC50:  250nMAssay Description:Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex mem...More data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50049205(CHEMBL48602 | RWJ-46458 | [4-Ethyl-4-methyl-6-oxo-...)
Affinity DataIC50:  250nMAssay Description:Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472199(CHEMBL169537)
Affinity DataIC50:  300nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50042058((-)-rolipram | (4R)-4-[3-(cyclopentyloxy)-4-methox...)
Affinity DataIC50:  300nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472198(CHEMBL354447)
Affinity DataIC50:  320nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50280330(CHEMBL51001 | [4-Ethyl-4-methyl-6-oxo-1-[2'-(1H-te...)
Affinity DataIC50:  320nMAssay Description:Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472195(CHEMBL166529)
Affinity DataIC50:  320nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50280327(CHEMBL295369 | [6-Oxo-4,4-dipropyl-1-[2'-(1H-tetra...)
Affinity DataIC50:  330nMAssay Description:Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50472194(CHEMBL169834)
Affinity DataIC50:  340nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50009714(CHEMBL191 | {2-Butyl-5-chloro-3-[2'-(2H-tetrazol-5...)
Affinity DataIC50:  420nMAssay Description:Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50009714(CHEMBL191 | {2-Butyl-5-chloro-3-[2'-(2H-tetrazol-5...)
Affinity DataIC50:  425nMAssay Description:Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex mem...More data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50280319(CHEMBL299151 | [4-Butyl-4-methyl-6-oxo-1-[2'-(1H-t...)
Affinity DataIC50:  470nMAssay Description:Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50:  500nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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