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LigandPNGBDBM50348228(CHEMBL1800807)
Affinity DataEC50:  3.90E+3nMAssay Description:Transactivation of PXR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50348226(CHEMBL1800622)
Affinity DataEC50:  2.60E+3nMAssay Description:Transactivation of PXR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50578767(CHEMBL4876714)
Affinity DataEC50:  7.50E+3nMAssay Description:Transactivation of PXR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50578768(CHEMBL4850728)
Affinity DataEC50: >3.00E+4nMAssay Description:Transactivation of PXR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50578769(CHEMBL4875002)
Affinity DataEC50: >3.00E+4nMAssay Description:Transactivation of PXR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50578770(CHEMBL4859118)
Affinity DataEC50: >3.00E+4nMAssay Description:Transactivation of PXR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50578771(CHEMBL4849688)
Affinity DataEC50: >3.00E+4nMAssay Description:Transactivation of PXR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50578772(CHEMBL4873416)
Affinity DataEC50: >3.00E+4nMAssay Description:Transactivation of PXR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50578733(CHEMBL4875851)
Affinity DataEC50: >3.00E+4nMAssay Description:Transactivation of PXR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50578773(CHEMBL4857594)
Affinity DataEC50:  300nMAssay Description:Transactivation of PXR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50578774(CHEMBL4868133)
Affinity DataEC50:  1.30E+4nMAssay Description:Transactivation of PXR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50578775(CHEMBL4846038)
Affinity DataEC50:  2.00E+3nMAssay Description:Transactivation of PXR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186377(3-(4-(5-(3-cyano-4-isopropoxyphenyl)-2H-tetrazol-2...)
Affinity DataEC50:  0.980nMAssay Description:Agonist activity at S1P1 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186378(3-(4-(5-(3-cyano-4-(1,1,1,3,3,3-hexafluoropropan-2...)
Affinity DataEC50:  38nMAssay Description:Agonist activity at S1P1 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186379(3-(4-(5-(3-cyano-4-isopropoxyphenyl)furan-2-yl)-3-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186382(3-(4-(2-(3-cyano-4-isopropoxyphenyl)thiazol-5-yl)-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at S1P3 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186380(3-(4-(5-(3-cyano-4-isopropoxyphenyl)-4-methyl-4H-1...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at S1P1 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186381(3-(4-(5-(3-cyano-4-isopropoxyphenyl)-4H-1,2,4-tria...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at S1P3 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186383(3-(4-(5-(3-cyano-4-(cyanomethoxy)phenyl)-1,3,4-thi...)
Affinity DataEC50:  45nMAssay Description:Agonist activity at S1P1 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186385(3-(4-(5-(3-cyano-4-(2,2-difluoroethoxy)phenyl)-1,3...)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at S1P1 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186386(3-(4-(5-(3-cyano-4-methoxyphenyl)-1,3,4-thiadiazol...)
Affinity DataEC50:  97nMAssay Description:Agonist activity at S1P1 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186384(3-(4-(5-(3-cyano-4-isopropoxyphenyl)-4-methylthiaz...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at S1P3 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186379(3-(4-(5-(3-cyano-4-isopropoxyphenyl)furan-2-yl)-3-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at S1P3 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186391(3-(4-(5-(3-cyano-4-isopropoxyphenyl)-1-methyl-1H-p...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at S1P1 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186389(3-(4-(5-(3-cyano-4-(2,2,2-trifluoroethoxy)phenyl)-...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at S1P1 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186390(3-(4-(5-(3-cyano-4-isopropoxyphenyl)thiophen-3-yl)...)
Affinity DataEC50:  3.20E+3nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186381(3-(4-(5-(3-cyano-4-isopropoxyphenyl)-4H-1,2,4-tria...)
Affinity DataEC50:  380nMAssay Description:Agonist activity at S1P1 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186388(3-(4-(5-(3-cyano-4-isopropoxyphenyl)oxazol-2-yl)-3...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186388(3-(4-(5-(3-cyano-4-isopropoxyphenyl)oxazol-2-yl)-3...)
Affinity DataEC50:  5.10nMAssay Description:Agonist activity at S1P1 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186387(3-(4-(5-(3-cyano-4-isobutoxyphenyl)-1,3,4-thiadiaz...)
Affinity DataEC50:  2.80nMAssay Description:Agonist activity at S1P1 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186392(3-(4-(5-(3-cyano-4-(3,3,3-trifluoropropoxy)phenyl)...)
Affinity DataEC50:  7.70nMAssay Description:Agonist activity at S1P1 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM22223(3-(4-{5-[3-cyano-4-(propan-2-yloxy)phenyl]-1,2,4-o...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186393(3-(4-(2-(3-cyano-4-isopropoxyphenyl)-2H-tetrazol-5...)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at S1P1 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186384(3-(4-(5-(3-cyano-4-isopropoxyphenyl)-4-methylthiaz...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186396(3-(4-(4-(3-cyano-4-isopropoxyphenyl)thiophen-2-yl)...)
Affinity DataEC50:  3.20E+3nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186394(3-(4-(5-(3-cyano-4-ethoxyphenyl)-1,3,4-thiadiazol-...)
Affinity DataEC50:  2.10nMAssay Description:Agonist activity at S1P1 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186395(3-(4-(5-(3-cyano-4-isopropoxyphenyl)-1,3,4-oxadiaz...)
Affinity DataEC50:  460nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186377(3-(4-(5-(3-cyano-4-isopropoxyphenyl)-2H-tetrazol-2...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at S1P3 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186396(3-(4-(4-(3-cyano-4-isopropoxyphenyl)thiophen-2-yl)...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at S1P3 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186398(3-(4-(5-(4-(carboxymethoxy)-3-cyanophenyl)-1,3,4-t...)
Affinity DataEC50:  360nMAssay Description:Agonist activity at S1P1 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186380(3-(4-(5-(3-cyano-4-isopropoxyphenyl)-4-methyl-4H-1...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at S1P3 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186381(3-(4-(5-(3-cyano-4-isopropoxyphenyl)-4H-1,2,4-tria...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186397(3-(4-(5-(3-cyano-4-isopropoxyphenyl)thiophen-2-yl)...)
Affinity DataEC50:  220nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186382(3-(4-(2-(3-cyano-4-isopropoxyphenyl)thiazol-5-yl)-...)
Affinity DataEC50:  200nMAssay Description:Agonist activity at S1P5 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186382(3-(4-(2-(3-cyano-4-isopropoxyphenyl)thiazol-5-yl)-...)
Affinity DataEC50:  14nMAssay Description:Agonist activity at S1P1 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186391(3-(4-(5-(3-cyano-4-isopropoxyphenyl)-1-methyl-1H-p...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at S1P3 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186400(3-(4-(5-(3-cyano-4-fluorophenyl)-1,3,4-thiadiazol-...)
Affinity DataEC50:  570nMAssay Description:Agonist activity at S1P1 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186401(3-(4-(5-(3-cyano-4-isobutylphenyl)-1,3,4-thiadiazo...)
Affinity DataEC50:  0.160nMAssay Description:Agonist activity at S1P1 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186399(3-(4-(5-(3-cyanophenyl)-1,3,4-thiadiazol-2-yl)-3-m...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at S1P1 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50186402(3-(4-(5-(3-cyano-4-isopropoxyphenyl)thiazol-2-yl)-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at S1P3 receptor assessed as induction of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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