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TargetTransthyretin(Human)
Autonomous University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50620814(CHEMBL5408344)
Affinity DataKd:  14nMAssay Description:Binding affinity to TTR V122I mutant (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
Autonomous University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50108877(CHEMBL1324 | Tasmar | Ro-40-7592 | (3,4-dihydroxy-...)
Affinity DataKd:  34nMAssay Description:Binding affinity to wild type TTR (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
Autonomous University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50108877(CHEMBL1324 | Tasmar | Ro-40-7592 | (3,4-dihydroxy-...)
Affinity DataKd:  440nMAssay Description:Binding affinity to TTR V30M mutant (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
Autonomous University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | Vyndaqel | US1...)
Affinity DataKd:  9.90nMAssay Description:Binding affinity to first binding site of wild type TTR (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTransthyretin(Human)
Autonomous University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | Vyndaqel | US1...)
Affinity DataKd:  260nMAssay Description:Binding affinity to second binding site of wild type TTR (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTransthyretin(Human)
Autonomous University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50588571(CHEMBL5172066)
Affinity DataKd:  31nMAssay Description:Binding affinity to wild type TTR (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTransthyretin(Human)
Autonomous University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50588575(CHEMBL5203058)
Affinity DataKd:  6.20nMAssay Description:Binding affinity to wild type TTR (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
Autonomous University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50588572(CHEMBL5183147)
Affinity DataKd:  310nMAssay Description:Binding affinity to wild type TTR (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTransthyretin(Human)
Autonomous University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50620814(CHEMBL5408344)
Affinity DataKd:  16nMAssay Description:Binding affinity to wild-type TTR (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
Autonomous University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50620814(CHEMBL5408344)
Affinity DataKd:  36nMAssay Description:Binding affinity to TTR V30M mutant (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
Autonomous University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50588573(CHEMBL5205412)
Affinity DataKd:  85nMAssay Description:Binding affinity to wild type TTR (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTransthyretin(Human)
Autonomous University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50108877(CHEMBL1324 | Tasmar | Ro-40-7592 | (3,4-dihydroxy-...)
Affinity DataKd:  50nMAssay Description:Binding affinity to TTR V122I mutant (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
Autonomous University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50108877(CHEMBL1324 | Tasmar | Ro-40-7592 | (3,4-dihydroxy-...)
Affinity DataKd:  34nMAssay Description:Binding affinity to wild type TTR (unknown origin) assessed as gibbs free energy change by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
Autonomous University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50108877(CHEMBL1324 | Tasmar | Ro-40-7592 | (3,4-dihydroxy-...)
Affinity DataKd:  48nMAssay Description:Binding affinity to wild-type TTR (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
Autonomous University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50588574(CHEMBL5172990)
Affinity DataKd:  26nMAssay Description:Binding affinity to wild type TTR (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
Universidad De Zaragoza

Curated by ChEMBL
LigandPNGBDBM50485878(CHEMBL2179243)
Affinity DataIC50: 700nMAssay Description:Inhibition of aggregation of human DHFR-fused amyloid beta (1 to 42) expressed in yeast harboring erg6delta assessed as increase in yeast viability m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Universidad De Zaragoza

Curated by ChEMBL
LigandPNGBDBM50485880(CHEMBL2179242)
Affinity DataIC50: 900nMAssay Description:Inhibition of aggregation of human DHFR-fused amyloid beta (1 to 42) expressed in yeast harboring erg6delta assessed as increase in yeast viability m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Universidad De Zaragoza

Curated by ChEMBL
LigandPNGBDBM50485879(CHEMBL1458517)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of aggregation of human DHFR-fused amyloid beta (1 to 42) expressed in yeast harboring erg6delta assessed as increase in yeast viability m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Universidad De Zaragoza

Curated by ChEMBL
LigandPNGBDBM50485881(CHEMBL2179241)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of aggregation of human DHFR-fused amyloid beta (1 to 42) expressed in yeast harboring erg6delta assessed as increase in yeast viability m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed