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TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50299523(2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide ...)
Affinity DataKi:  340nMAssay Description:Inhibition of TNAP using CDP-star as substrate by non-competitive Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50440737(CHEMBL2431120)
Affinity DataKi:  410nMAssay Description:Binding affinity to sigma-1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50299523(2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide ...)
Affinity DataKi:  590nMAssay Description:Inhibition of TNAP using DEA as substrate by non-competitive Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50440737(CHEMBL2431120)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to 5-HT3 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50440737(CHEMBL2431120)
Affinity DataKi:  1.42E+3nMAssay Description:Binding affinity to histamine H1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50440737(CHEMBL2431120)
Affinity DataKi:  2.54E+3nMAssay Description:Binding affinity to PBR receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50248035((2S)-2-(1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxy...)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of NTS1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50248035((2S)-2-(1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxy...)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of MOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50248035((2S)-2-(1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxy...)
Affinity DataKi:  5.20E+3nMAssay Description:Inhibition of DOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50444943(CHEMBL3099773)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of NTS1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50248035((2S)-2-(1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxy...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of DAT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50444943(CHEMBL3099773)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of DAT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50440738(CHEMBL2431105)
Affinity DataIC50:  0.240nMAssay Description:Displacement of [125I]-neurotensin from NTR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50440738(CHEMBL2431105)
Affinity DataIC50:  0.240nMAssay Description:Displacement of [125I]-neurotensin from NTR1 in HUVEC after 1 hr by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM62288(4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-N-[4-(tr...)
Affinity DataIC50:  30nMAssay Description:Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50440738(CHEMBL2431105)
Affinity DataIC50:  50nMAssay Description:Antagonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin assessed as inhibition of ML314-induced effect ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM62288(4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-N-[4-(tr...)
Affinity DataIC50:  80nMAssay Description:Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM62170(1-(4-chlorophenyl)sulfonyl-2-benzimidazolamine | 1...)
Affinity DataIC50:  90nMAssay Description:Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50299534(5-Bromo-2-methoxy-N-(quinolin-3-yl)benzenesulfonam...)
Affinity DataIC50:  120nMAssay Description:Inhibition of TNAP transfected in african green monkey COS1 cells by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM54409(4-[4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-benzo...)
Affinity DataIC50:  150nMAssay Description:Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50299523(2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide ...)
Affinity DataIC50:  190nMAssay Description:Inhibition of TNAP transfected in african green monkey COS1 cells by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM62251(MLS-0412140.0001 | cid_44182145 | cyclopropyl-[2-m...)
Affinity DataIC50:  200nMAssay Description:Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50299523(2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide ...)
Affinity DataIC50:  230nMAssay Description:Inhibition of TNAP right after mixing with enzyme (EI 0:0) by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM62261(4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-N-(4-met...)
Affinity DataIC50:  240nMAssay Description:Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50299523(2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide ...)
Affinity DataIC50:  240nMAssay Description:Inhibition of TNAP after 1 hr incubation with enzyme post-dilution (EI 1:0) by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM62251(MLS-0412140.0001 | cid_44182145 | cyclopropyl-[2-m...)
Affinity DataIC50:  260nMAssay Description:Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM62261(4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-N-(4-met...)
Affinity DataIC50:  260nMAssay Description:Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50299523(2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide ...)
Affinity DataIC50:  270nMAssay Description:Inhibition of TNAP after 1 hr pre-incubation with enzyme (EI 1:1) by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM62257(MLS-0360553.0001 | cid_20901691 | cyclopropyl-[5-[...)
Affinity DataIC50:  390nMAssay Description:Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM54409(4-[4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-benzo...)
Affinity DataIC50:  400nMAssay Description:Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM62295(4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-N-(4-met...)
Affinity DataIC50:  510nMAssay Description:Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50299525(5-chloro-2-methoxy-4-methyl-N-(pyridin-3-yl)benzen...)
Affinity DataIC50:  510nMAssay Description:Inhibition of TNAP transfected in african green monkey COS1 cells by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM62257(MLS-0360553.0001 | cid_20901691 | cyclopropyl-[5-[...)
Affinity DataIC50:  510nMAssay Description:Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50299526(5-chloro-2-ethoxy-N-(pyridin-3-yl)benzenesulfonami...)
Affinity DataIC50:  540nMAssay Description:Inhibition of TNAP transfected in african green monkey COS1 cells by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM59542((1-tosylbenzimidazol-2-yl)amine | 1-(4-methylpheny...)
Affinity DataIC50:  560nMAssay Description:Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM59544(4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(4-eth...)
Affinity DataIC50:  570nMAssay Description:Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM62249(1-[5-[4-(4-chlorophenyl)piperazin-1-yl]sulfonyl-2-...)
Affinity DataIC50:  600nMAssay Description:Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50299535(2-Methoxy-5-methyl-N-(quinolin-3-yl)benzenesulfona...)
Affinity DataIC50:  650nMAssay Description:Inhibition of TNAP transfected in african green monkey COS1 cells by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50299527(5-chloro-2-ethoxy-4-methyl-N-(pyridin-3-yl)benzene...)
Affinity DataIC50:  690nMAssay Description:Inhibition of TNAP transfected in african green monkey COS1 cells by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50393964(CHEMBL2158347)
Affinity DataIC50:  700nMAssay Description:Antagonist activity at APJ receptor assessed as inhibition of apelin13-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50299536(2-Methoxy-4-nitro-N-(quinolin-3-yl)benzenesulfonam...)
Affinity DataIC50:  740nMAssay Description:Inhibition of TNAP transfected in african green monkey COS1 cells by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM62295(4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-N-(4-met...)
Affinity DataIC50:  780nMAssay Description:Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM54413(CHEMBL1612423 | MLS001202690 | N-(4-Chloro-phenyl)...)
Affinity DataIC50:  830nMAssay Description:Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate dehydrogenase(malaria parasite P. falciparum)
University of California

Curated by ChEMBL
LigandPNGBDBM50396489(CHEMBL2170943)
Affinity DataIC50:  900nMAssay Description:Inhibition of Plasmodium falciparum glucose-6-phosphate dehydrogenase after 2 hrs by resazurin/diaphorasecoupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMannose-6-phosphate isomerase(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM44446(4-[2-[[(5Z)-5-(3-indolylidene)-4-(2-methoxyethyl)-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human purified phosphomannose isomeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMannose-6-phosphate isomerase(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM44461(5-[(2-methoxyphenyl)-oxomethoxy]-1-phenyl-3-pyrazo...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human purified phosphomannose isomeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM62249(1-[5-[4-(4-chlorophenyl)piperazin-1-yl]sulfonyl-2-...)
Affinity DataIC50:  1.01E+3nMAssay Description:Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM62302(MLS-0425608.0001 | N-(4-bromophenyl)-4-(3,4-dihydr...)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50299524(2,5-Dimethoxy-N-(pyridin-3-yl)benzenesulfonamide |...)
Affinity DataIC50:  1.06E+3nMAssay Description:Inhibition of TNAP transfected in african green monkey COS1 cells by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM59544(4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(4-eth...)
Affinity DataIC50:  1.13E+3nMAssay Description:Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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