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TargetIntegrin alpha-IIb/beta-3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287969((S)-3-{[(R)-1-(3-Piperidin-4-yl-propionyl)-piperid...)
Affinity DataIC50:  0.100nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287978((S)-3-{[(R)-1-(3-Piperidin-4-yl-propionyl)-piperid...)
Affinity DataIC50:  0.100nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287967((S)-3-Benzo[1,3]dioxol-5-yl-3-{[(R)-1-(3-piperidin...)
Affinity DataIC50:  0.5nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225162((4R)-N-[2-(dimethylamino)ethyl]-1-({4-[(2-phenylbe...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287982(3-{[1-(3-Piperazin-1-yl-propionyl)-piperidine-3-ca...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287983(5-Methyl-3-{[1-(3-piperidin-4-yl-propionyl)-piperi...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287985(3-Phenyl-3-{[1-(3-piperidin-4-yl-propionyl)-piperi...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50083467((S)-5-Phenyl-3-{[(R)-1-(3-piperidin-4-yl-propionyl...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287972(2-{[1-(3-Piperidin-4-yl-propionyl)-piperidine-3-ca...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50083463((R)-3-{[(R)-1-(3-Piperidin-4-yl-propionyl)-piperid...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287977(3-{[(S)-1-(3-Piperidin-4-yl-propionyl)-piperidine-...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225163((4R)-1-({4-[(2-chloro-5-fluorobenzene)amido]-3-met...)
Affinity DataIC50:  5nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50083459(2-Hydroxy-3-{[(R)-1-(3-piperidin-4-yl-propionyl)-p...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetVasopressin V2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  5nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287973(3-({1-[3-(1-Methyl-piperidin-4-yl)-propionyl]-pipe...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50034703(3-{[1-(3-Piperidin-4-yl-propionyl)-piperidine-3-ca...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50083452(3-{[(R)-1-(3-Piperidin-4-yl-propionyl)-piperidine-...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287981(3-{[1-(3-Piperidin-4-yl-propionyl)-pyrrolidine-3-c...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetVasopressin V2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225162((4R)-N-[2-(dimethylamino)ethyl]-1-({4-[(2-phenylbe...)
Affinity DataIC50:  8nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225166((4R)-1-({4-[(2-chloro-5-fluorobenzene)amido]-3-eth...)
Affinity DataIC50:  8nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225167(CHEMBL250346 | N-(4-{[3'-(hydroxymethyl)-1,2,3,5-t...)
Affinity DataIC50:  9nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225167(CHEMBL250346 | N-(4-{[3'-(hydroxymethyl)-1,2,3,5-t...)
Affinity DataIC50:  9nMAssay Description:Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracllular calciu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287970(4-Oxo-1-[1-(3-piperidin-4-yl-propionyl)-piperidine...)
Affinity DataIC50:  9nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287980(3-{[1-(3-Piperidin-4-yl-propionyl)-azepane-3-carbo...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetVasopressin V2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225159((4R)-1-({4-[(2-chloro-5-fluorobenzene)amido]-3-met...)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at human vasopressin V2 receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced cAMP levelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225173((4R)-1-({4-[(2-chloro-5-fluorobenzene)amido]phenyl...)
Affinity DataIC50:  13nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225168(1-({4-[(2-phenylbenzene)amido]phenyl}carbonyl)-1,2...)
Affinity DataIC50:  14nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225172(CHEMBL251771 | methyl 1-({4-[(2-fluorobenzene)amid...)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225167(CHEMBL250346 | N-(4-{[3'-(hydroxymethyl)-1,2,3,5-t...)
Affinity DataIC50:  18nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225170(CHEMBL400267 | N-[4-({3'-[(methylamino)methyl]-1,2...)
Affinity DataIC50:  18nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225160(1-({4-[(2-chloro-5-fluorobenzene)amido]-3-methoxyp...)
Affinity DataIC50:  19nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287978((S)-3-{[(R)-1-(3-Piperidin-4-yl-propionyl)-piperid...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibition of thrombin-induced human gel-filtered platelet aggregation.More data for this Ligand-Target Pair
In DepthDetails Article
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225168(1-({4-[(2-phenylbenzene)amido]phenyl}carbonyl)-1,2...)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracllular calciu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287979(3-{[1-(2-Piperidin-4-yl-ethanesulfonyl)-piperidine...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetProteinase-activated receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287967((S)-3-Benzo[1,3]dioxol-5-yl-3-{[(R)-1-(3-piperidin...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibition of thrombin-induced human gel-filtered platelet aggregation.More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287976(3-({1-[(Piperidin-4-ylmethyl)-carbamoyl]-piperidin...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287965(3-(2-Carboxy-ethylcarbamoyl)-piperidine-1-carboxyl...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50083476((S)-6,6-Dimethyl-3-{[(R)-1-(3-piperidin-4-yl-propi...)
Affinity DataIC50:  21nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225159((4R)-1-({4-[(2-chloro-5-fluorobenzene)amido]-3-met...)
Affinity DataIC50:  27nMAssay Description:Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracllular calciu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225163((4R)-1-({4-[(2-chloro-5-fluorobenzene)amido]-3-met...)
Affinity DataIC50:  30nMAssay Description:Antagonist activity at rat vasopressin V2 receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced cAMP levelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225161(1-({4-[(2-chloro-5-fluorobenzene)amido]phenyl}carb...)
Affinity DataIC50:  32nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225163((4R)-1-({4-[(2-chloro-5-fluorobenzene)amido]-3-met...)
Affinity DataIC50:  34nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225162((4R)-N-[2-(dimethylamino)ethyl]-1-({4-[(2-phenylbe...)
Affinity DataIC50:  36nMAssay Description:Antagonist activity at human vasopressin V2 receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced cAMP levelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225168(1-({4-[(2-phenylbenzene)amido]phenyl}carbonyl)-1,2...)
Affinity DataIC50:  37nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225163((4R)-1-({4-[(2-chloro-5-fluorobenzene)amido]-3-met...)
Affinity DataIC50:  38nMAssay Description:Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracllular calciu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225171(2-chloro-5-fluoro-N-(2-methoxy-4-{[(4R)-3'-(1H-1,2...)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at human vasopressin V2 receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced cAMP levelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225174(CHEMBL249536 | methyl 1-({4-[(2-chloro-5-fluoroben...)
Affinity DataIC50:  40nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225170(CHEMBL400267 | N-[4-({3'-[(methylamino)methyl]-1,2...)
Affinity DataIC50:  44nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225162((4R)-N-[2-(dimethylamino)ethyl]-1-({4-[(2-phenylbe...)
Affinity DataIC50:  45nMAssay Description:Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracllular calciu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225166((4R)-1-({4-[(2-chloro-5-fluorobenzene)amido]-3-eth...)
Affinity DataIC50:  50nMAssay Description:Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracllular calciu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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