Compile Data Set for Download or QSAR
Found 314 with Last Name = 'vongs' and Initial = 'a'
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50220703((R)-N-((S)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...)
Affinity DataIC50:  0.850nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50136531((R)-1,2,3,4-Tetrahydro-quinoline-2-carboxylic acid...)
Affinity DataIC50:  1.20nMAssay Description:Concentration required to inhibit binding of [125I]-NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-4-rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50136534(3-[6-(4-Chloro-phenylsulfanyl)-2-(4-methoxy-phenyl...)
Affinity DataIC50:  2.30nMAssay Description:Concentration required to inhibit binding of [125I]NDP-alpha-MSH from membranes prepared from CHO cells expressing human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50164760((2S,5S)-5-Ethyl-piperazine-2-carboxylic acid [(R)-...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50164772((2S,5S)-5-Ethyl-4-methyl-piperazine-2-carboxylic a...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50220696((R)-N-((S)-3-(4-chlorophenyl)-1-(4-((1-methyl-1H-t...)
Affinity DataIC50:  3.60nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50220689((R)-N-((S)-1-(4-sec-butyl-4-((1-methyl-1H-tetrazol...)
Affinity DataIC50:  3.70nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50220700((R)-N-((S)-3-(4-chlorophenyl)-1-(4-hexyl-4-((1-met...)
Affinity DataIC50:  4nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50164763((2S,5S)-5-Isopropyl-piperazine-2-carboxylic acid [...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50164775((2S,5S)-5-tert-Butyl-piperazine-2-carboxylic acid ...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50164766((2S,5S)-5-(1-Methyl-cyclopropyl)-piperazine-2-carb...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50136535(3-[6-(4-Chloro-phenylsulfanyl)-2-(4-methoxy-phenyl...)
Affinity DataIC50:  5.60nMAssay Description:Concentration required to inhibit binding of [125I]NDP-alpha-MSH from membranes prepared from CHO cells expressing human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50220691((R)-N-((S)-3-(4-chlorophenyl)-1-(4-isobutyl-4-((1-...)
Affinity DataIC50:  6nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50169445((1S,4R,6S)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataIC50:  6nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 4 by displacement of [125I]-NDP-alpha-MSH from the human receptors ex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50164762((2S,5S)-5-Methyl-piperazine-2-carboxylic acid [(R)...)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50220699((R)-N-((S)-1-(4-(tert-butylcarbamoyl)-4-(4-methylc...)
Affinity DataIC50:  6.80nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50220693((R)-N-((S)-3-(4-chlorophenyl)-1-(4-(cyanomethyl)-4...)
Affinity DataIC50:  6.80nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50157314((S)-4-Methyl-piperazine-2-carboxylic acid [(R)-2-(...)
Affinity DataIC50:  7nMAssay Description:Concentration for 50% inhibition of human melanocortin-4 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50157314((S)-4-Methyl-piperazine-2-carboxylic acid [(R)-2-(...)
Affinity DataIC50:  7nMAssay Description:Concentration for 50% inhibition of human melanocortin-4 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50027107(CHEMBL2145455)
Affinity DataIC50:  8nMAssay Description:Concentration for 50% inhibition of human melanocortin-4 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50169442((1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataIC50:  8nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 4 by displacement of [125I]-NDP-alpha-MSH from the human receptors ex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50164771((2S,5S)-5-Cyclopropyl-piperazine-2-carboxylic acid...)
Affinity DataIC50:  8nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50027169(CHEMBL2028962)
Affinity DataIC50:  11nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50323150(CHEMBL1209253 | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2...)
Affinity DataIC50:  13nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50027131(CHEMBL2145454)
Affinity DataIC50:  13nMAssay Description:Concentration for 50% inhibition of human melanocortin-4 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50323150(CHEMBL1209253 | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2...)
Affinity DataIC50:  13nMAssay Description:Agonist activity at human MC4 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50220710((R)-N-((S)-1-(4-(tert-butylcarbamoyl)-4-cyclohexyl...)
Affinity DataIC50:  14nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50169444((1S,4S,6S)-2-Aza-bicyclo[2.2.2]octane-6-carboxylic...)
Affinity DataIC50:  14nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 4 by displacement of [125I]-NDP-alpha-MSH from the human receptors ex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50024351(CHEMBL2113031)
Affinity DataIC50:  16nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 4 by displacement of [125I]-NDP-alpha-MSH from the human receptors ex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50220711((R)-N-((S)-3-(4-chlorophenyl)-1-(4-(cyanomethyl)-4...)
Affinity DataIC50:  16nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50027168(CHEMBL2028961)
Affinity DataIC50:  17nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50157320((S)-1-Methyl-piperazine-2-carboxylic acid [(R)-2-(...)
Affinity DataIC50:  18nMAssay Description:Concentration for 50% inhibition of human melanocortin-4 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50029747((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)
Affinity DataIC50:  19nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 4 by displacement of [125I]-NDP-alpha-MSH from the human receptors ex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029747((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)
Affinity DataIC50:  19nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50029747((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)
Affinity DataIC50:  19nMAssay Description:Inhibitory concentration to displace [125I]-NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50029747((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)
Affinity DataIC50:  19nMAssay Description:Concentration for 50% inhibition of human melanocortin-4 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50157321((R)-4-Methyl-piperazine-2-carboxylic acid [(R)-2-(...)
Affinity DataIC50:  20nMAssay Description:Concentration for 50% inhibition of human melanocortin-4 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50027174(CHEMBL2028957)
Affinity DataIC50:  20nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50220690((R)-N-((S)-1-(4-butyl-4-(cyanomethyl)piperidin-1-y...)
Affinity DataIC50:  22nMAssay Description:Binding affinity to human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50323159(CHEMBL1209321 | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2...)
Affinity DataIC50:  23nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50323159(CHEMBL1209321 | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2...)
Affinity DataIC50:  23nMAssay Description:Agonist activity at human MC4 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50027172(CHEMBL2028960)
Affinity DataIC50:  24nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50027170(CHEMBL2028958)
Affinity DataIC50:  25nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50323158(CHEMBL1209382 | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2...)
Affinity DataIC50:  27nMAssay Description:Agonist activity at human MC4 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50323158(CHEMBL1209382 | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2...)
Affinity DataIC50:  27nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50169443((1R,4S,6S)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataIC50:  28nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 4 by displacement of [125I]-NDP-alpha-MSH from the human receptors ex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50027171(CHEMBL2028959)
Affinity DataIC50:  29nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50323151(CHEMBL1209252 | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2...)
Affinity DataIC50:  29nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50323151(CHEMBL1209252 | N-(2-(4-((3S,4R)-1-tert-butyl-4-(2...)
Affinity DataIC50:  29nMAssay Description:Agonist activity at human MC4 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50027156(CHEMBL2145456)
Affinity DataIC50:  30nMAssay Description:Concentration for 50% inhibition of human melanocortin-4 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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