Report error Found 10576 with Last Name = 'wang' and Initial = 'b'
Affinity DataEC50: 750nMAssay Description:VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...More data for this Ligand-Target Pair
Affinity DataEC50: 48nMAssay Description:VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...More data for this Ligand-Target Pair
Affinity DataEC50: 490nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 97nMAssay Description:Agonist activity at FXR-LBD (unknown origin) assessed by ligand binding ability incubated for 3 hrs in absence of light measured by TR-FRET Coactivat...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Human)
Guangdong Pharmaceutical University
Curated by ChEMBL
Guangdong Pharmaceutical University
Curated by ChEMBL
Affinity DataEC50: 652nMAssay Description:Agonist activity at human PPARdelta transfected in human HEK293 cells incubated for 18 hrs by Renilla/Firefly dual-luciferase reporter assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataEC50: 9.60E+4nMAssay Description:Agonist activity at STING in human THP1 Dual cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in human STHP1-Dual KO-STING cells incubated for 20 hrs by Quanti-luc reagent based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 854nMAssay Description:Agonist activity at FXR-LBD (unknown origin) using fluorescein-coactivator peptide incubated for 3 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataEC50: 1.85E+3nMAssay Description:Agonist activity at FXR (unknown origin) expressed in human HepG2 cells co-transfected with human RXR assessed as luciferase activity incubated for 2...More data for this Ligand-Target Pair
Ligand Info
TargetAdenosine receptor A2b(Human)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 1.12E+5nMAssay Description:Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclaseMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Human)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 3.08E+7nMAssay Description:Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclaseMore data for this Ligand-Target Pair
Affinity DataEC50: 4.80E+4nMAssay Description:A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:The assay utilizes non-human mammalian cells, CHO (Chinese hamster ovary) cells engineered to express human NR1H4 protein (referred to as FXR). Repor...More data for this Ligand-Target Pair
Affinity DataEC50: 18.6nMAssay Description:To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...More data for this Ligand-Target Pair
Affinity DataEC50: 544nMAssay Description:To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...More data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...More data for this Ligand-Target Pair
TargetFusion glycoprotein F0(Human respiratory syncytial virus)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 120nMAssay Description:Inhibition of RSV Long fusion protein assessed as protection against virus induced cytopathic effect in infected human Hep2 cells after 5 days by CCK...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Mannheim University of Applied Sciences
Curated by ChEMBL
Mannheim University of Applied Sciences
Curated by ChEMBL
Affinity DataEC50: 870nMAssay Description:Agonist activity at recombinant TRPV1 (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux administered for 1 min followe...More data for this Ligand-Target Pair
Affinity DataEC50: <10nMAssay Description:Inhibition of FLT3 in human MOLM14 cells assessed as inhibition of STAT5 phosphorylation at Tyr694 site after 4 hrs by immunoblotting analysisMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at FXR-LBD (unknown origin) assessed by ligand binding ability incubated for 3 hrs in absence of light measured by TR-FRET Coactivat...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
Guangdong Pharmaceutical University
Curated by ChEMBL
Guangdong Pharmaceutical University
Curated by ChEMBL
Affinity DataEC50: 3.96E+3nMAssay Description:Agonist activity at human PPARgamma transfected in human HEK293 cells incubated for 18 hrs by Renilla/Firefly dual-luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 12nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mouse)
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in mouse RAW-Lucia ISG cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene ass...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in human THP1 Dual KO-STING cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gen...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in human THP1-Dual cells incubated for 20 hrs by Quanti-luc reagent based assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in human STHP1-Dual KO-STING cells incubated for 20 hrs by Quanti-luc reagent based assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in human STHP1-Dual KO-STING cells incubated for 20 hrs by Quanti-luc reagent based assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Human)
Guangdong Pharmaceutical University
Curated by ChEMBL
Guangdong Pharmaceutical University
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at pBIND-PPARalpha (unknown origin) transfected in HepG2 cells incubated for 18 hrs by renilla/firefly based dual-glo luciferase ass...More data for this Ligand-Target Pair
Ligand Info
Affinity DataEC50: 440nMAssay Description:Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucoseMore data for this Ligand-Target Pair
Affinity DataAssay Description:To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...More data for this Ligand-Target Pair
Affinity DataEC50: 58nMAssay Description:To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...More data for this Ligand-Target Pair
Affinity DataEC50: 560nMAssay Description:Four hours later, serial dilutions of 10× compound stocks were made in growth medium from 500×DMSO stocks, and 20 μL of those 10× stocks were ad...More data for this Ligand-Target Pair
Affinity DataEC50: 6.20nMAssay Description:About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...More data for this Ligand-Target Pair
Affinity DataEC50: 52nMAssay Description:About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at VDR in human HL60 cells assessed as induction of cell differentiation after 96 hrs by NBT assayMore data for this Ligand-Target Pair
TargetFusion glycoprotein F0(Human respiratory syncytial virus)
Roche Pharma Research and Early Development
Curated by ChEMBL
Roche Pharma Research and Early Development
Curated by ChEMBL
Affinity DataEC50: 150nMAssay Description:Inhibition of RSV Long fusion protein assessed as protection against virus induced cytopathic effect in infected human Hep2 cells after 5 days by CCK...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of RNA-dependent RNA polymerase in ZIKV SL0612 infected in African green monkey Vero cells assessed as reduction in virus-induced cytopath...More data for this Ligand-Target Pair
Affinity DataKd: 140nMAssay Description:Binding affinity to RIOK2 (unknown origin)More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Human)
Guangdong Pharmaceutical University
Curated by ChEMBL
Guangdong Pharmaceutical University
Curated by ChEMBL
Affinity DataEC50: 7.73E+3nMAssay Description:Agonist activity at human PPARalpha transfected in human HepG2 cells incubated for 18 hrs by Renilla/Firefly dual-luciferase reporter assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataEC50: 530nMAssay Description:Agonist activity at STING in human THP1 Dual cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mouse)
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Bristol Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataEC50: 1.90E+3nMAssay Description:Agonist activity at STING in mouse RAW-Lucia ISG cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene ass...More data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at human TLR8More data for this Ligand-Target Pair
Affinity DataEC50: 167nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing vincristine resistance measured as cell survival ...More data for this Ligand-Target Pair
Affinity DataEC50: <30nMAssay Description:Inhibition of FLT3 mediated Stat5 phosphorylation in human MV4-11 cells for 4 hrs by immunoblot analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 285nMAssay Description:Inhibition of PARP in human LoVo cells assessed as inhibition of poly(ADP)-ribose polymerization for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at rat alpha4beta2 nAChR expressed in HEK293 cells for 2 mins by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: >50nMAssay Description:Agonist activity at VDR in human HL60 cells assessed as induction of cell differentiation by measuring increase in NBT positive cells by Wright stain...More data for this Ligand-Target Pair
Affinity DataEC50: 9.30nMAssay Description:Agonist activity at rat alpha7 nAChR expressed in HEK293 cells assessed as increase in Ca2+ flux by Fluo-4 AM dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 87nMAssay Description:About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...More data for this Ligand-Target Pair
Affinity DataEC50: 7nMAssay Description:Four hours later, serial dilutions of 10× compound stocks were made in growth medium from 500×DMSO stocks, and 20 μL of those 10× stocks were ad...More data for this Ligand-Target Pair
