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Report error Found 10717 with Last Name = 'wang' and Initial = 'f'

Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

Ki: 0.00120nMAssay Description:Inhibition of HIV1 wild type NL4-3 protease expressed in Escherichia coli Rosetta (DE3) pLysS using Abz-Thr-Ile-Nle-Phe-(pNO2)-Gln-Arg-NH2 as substra...More data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50498523(CHEMBL3605643)

Ki: 0.00150nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50484842(CHEMBL1958482 | GRL-0249A)

Ki: 0.00180nMAssay Description:Inhibition of HIV1 protease using hexapeptide Ac-Thr-Ile-Nle-Nle-Gln-Arg-NH2 as substrate by fluorimetric assayMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50457611(CHEMBL4214453)

Ki: 0.00200nMAssay Description:Inhibition of wild type HIV-1 NL4-3 protease expressed in Escherichia coli Rosetta (DE3)pLysS using Ac-Thr-Ile-Nle-Nle-Gln-Arg-NH2 as substrate by fl...More data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50528147(CHEMBL4514504)

Ki: 0.00200nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50528152(CHEMBL4532946)

Ki: 0.00200nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50498524(CHEMBL3605638)

Ki: 0.00390nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50484847(CHEMBL1958483 | GRL-0289A)

Ki: 0.00400nMAssay Description:Inhibition of HIV1 protease using hexapeptide Ac-Thr-Ile-Nle-Nle-Gln-Arg-NH2 as substrate by fluorimetric assayMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50457604(CHEMBL4213229)

Ki: 0.00500nMAssay Description:Inhibition of wild type HIV-1 NL4-3 protease expressed in Escherichia coli Rosetta (DE3)pLysS using Ac-Thr-Ile-Nle-Nle-Gln-Arg-NH2 as substrate by fl...More data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50484190(CHEMBL1817686)

Ki: 0.00500nMAssay Description:Inhibition of Human immunodeficiency virus 1 protease assessed as release of fluorescent N-terminal tripeptide using fluorogenic substrate by continu...More data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50528144(CHEMBL4435411)

Ki: 0.00600nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50489369(CHEMBL1232930 | GRL-0519)

Ki: 0.00600nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50484193(CHEMBL1819294)

Ki: 0.00600nMAssay Description:Inhibition of Human immunodeficiency virus 1 protease assessed as release of fluorescent N-terminal tripeptide using fluorogenic substrate by continu...More data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50484191(CHEMBL1819295)

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50498534(CHEMBL3605635)

Ki: 0.00630nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50528145(CHEMBL4586218)

Ki: 0.00700nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50484845(CHEMBL1958480)

Ki: 0.00740nMAssay Description:Inhibition of HIV1 protease using hexapeptide Ac-Thr-Ile-Nle-Nle-Gln-Arg-NH2 as substrate by fluorimetric assayMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50484841(CHEMBL1958481)

Ki: 0.00750nMAssay Description:Inhibition of HIV1 protease using hexapeptide Ac-Thr-Ile-Nle-Nle-Gln-Arg-NH2 as substrate by fluorimetric assayMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50457612(CHEMBL4218164)

Ki: 0.00800nMAssay Description:Inhibition of wild type HIV-1 NL4-3 protease expressed in Escherichia coli Rosetta (DE3)pLysS using Ac-Thr-Ile-Nle-Nle-Gln-Arg-NH2 as substrate by fl...More data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50528150(CHEMBL4449179)

Ki: 0.00800nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50528154(CHEMBL4545005)

Ki: 0.00800nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50520752(CHEMBL4474261)

Ki: 0.00800nMAssay Description:Inhibition of HIV1 protease using fluorogenic substrate by continuous fluorometric assayMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50498528(CHEMBL3605644)

Ki: 0.00990nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50457608(CHEMBL4211505)

Ki: 0.0100nMAssay Description:Inhibition of wild type HIV-1 NL4-3 protease expressed in Escherichia coli Rosetta (DE3)pLysS using Ac-Thr-Ile-Nle-Nle-Gln-Arg-NH2 as substrate by fl...More data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50493304(CHEMBL2426453)

Ki: 0.0100nMAssay Description:Inhibition of HIV1 LAI protease by fluorescence assayMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50498531(CHEMBL3605642)

Ki: 0.0120nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50498326(CHEMBL3581674)

Ki: 0.0120nMAssay Description:Inhibition of wild type HIV1 proteaseMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50457610(CHEMBL4207145)

Ki: 0.0120nMAssay Description:Inhibition of wild type HIV-1 NL4-3 protease expressed in Escherichia coli Rosetta (DE3)pLysS using Ac-Thr-Ile-Nle-Nle-Gln-Arg-NH2 as substrate by fl...More data for this Ligand-Target Pair

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Dimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Purdue University

BDBM35968(cyclic compound, 14c | cyclic compound, 14c-Z)

Ki: 0.0120nM ΔG°: -62.3kJ/mole EC50: 4.60nMpH: 6.4 T: 25°CAssay Description:The Ki values were determined by substrate cleavage assay using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-Arg-NH2. A standar...More data for this Ligand-Target Pair

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Dimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Purdue University

BDBM9236((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.0140nM ΔG°: -62.0kJ/mole EC50: 1.20nMpH: 6.4 T: 25°CAssay Description:The Ki values were determined by substrate cleavage assay using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-Arg-NH2. A standar...More data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50498530(CHEMBL3605637)

Ki: 0.0140nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50498527(CHEMBL3605640)

Ki: 0.0140nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50498526(CHEMBL3605636)

Ki: 0.0140nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50498327(CHEMBL3581664)

Ki: 0.0140nMAssay Description:Inhibition of wild type HIV1 proteaseMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50498324(CHEMBL3581666)

Ki: 0.0140nMAssay Description:Inhibition of wild type HIV1 proteaseMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.0160nMAssay Description:Inhibition of HIV1 wild type NL4-3 protease expressed in Escherichia coli Rosetta (DE3) pLysS using Abz-Thr-Ile-Nle-Phe-(pNO2)-Gln-Arg-NH2 as substra...More data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50469413(CHEMBL4286231)

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.0160nMAssay Description:Inhibition of wild type HIV-1 NL4-3 protease expressed in Escherichia coli Rosetta (DE3)pLysS using Ac-Thr-Ile-Nle-Nle-Gln-Arg-NH2 as substrate by fl...More data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.0160nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.0160nMAssay Description:Inhibition of HIV-1 protease by fluorometric assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50469407(CHEMBL4286714)

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.0160nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair

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3D Structure (crystal)

Dimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Purdue University

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.0160nM ΔG°: -61.6kJ/mole EC50: 1.60nMpH: 6.4 T: 25°CAssay Description:The Ki values were determined by substrate cleavage assay using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-Arg-NH2. A standar...More data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)

Ki: 0.0160nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair

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3D Structure (crystal)

Dimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Purdue University

BDBM35984(cyclic compound, 15d)

Ki: 0.0170nM EC50: 14nMAssay Description:The Ki values were determined by substrate cleavage assay using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-Arg-NH2. A standar...More data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50484196(CHEMBL1819297)

Ki: 0.0170nMAssay Description:Inhibition of Human immunodeficiency virus 1 protease assessed as release of fluorescent N-terminal tripeptide using fluorogenic substrate by continu...More data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50484844(CHEMBL1958486)

Ki: 0.0200nMAssay Description:Inhibition of HIV1 protease using hexapeptide Ac-Thr-Ile-Nle-Nle-Gln-Arg-NH2 as substrate by fluorimetric assayMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50493301(CHEMBL2426458)

Ki: 0.0210nMAssay Description:Inhibition of HIV1 LAI protease by fluorescence assayMore data for this Ligand-Target Pair

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Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50561628(CHEMBL4800615)

Ki: 0.0220nMAssay Description:Inhibition of HIV1 protease by fluorescence based assayMore data for this Ligand-Target Pair

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Protease(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL

BDBM50528151(CHEMBL4533315)

Ki: 0.0240nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair

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Displayed 1 to 50 (of 10717 total ) | Next | Last >>

Filter my 10717 hits

Targets 328▿
- CREB-binding protein 849
- Epidermal growth factor receptor 650
- Sodium-dependent dopamine transporter 493
- Sodium-dependent serotonin transporter 492
- Bromodomain-containing protein 4 448
- Neuroepithelial cell-transforming gene 1 protein 354
- WD repeat-containing protein 5 280
- Tyrosine-protein kinase BTK 270
- Receptor tyrosine-protein kinase erbB-2 206
- Replicase polyprotein 1ab 162
- Kinesin-like protein KIF11 158
- Nuclear receptor ROR-gamma 154
- Protease 149
- Muscarinic acetylcholine receptor M3 134
- Poly [ADP-ribose] polymerase 1 133
- Protoporphyrinogen oxidase 121
- Tyrosine-protein kinase ABL1 118
- Urease subunit beta 115
- Transitional endoplasmic reticulum ATPase 111
- Sodium-dependent noradrenaline transporter 111
- Indoleamine 2,3-dioxygenase 1 97
- RNA-directed RNA polymerase 94
- CREB-binding protein/Histone acetyltransferase p300 90
- High affinity nerve growth factor receptor 89
- Cytochrome P450 3A4 86
- Histone deacetylase 1 82
- Potassium voltage-gated channel subfamily H member 2 82
- 72 kDa type IV collagenase 77
- Acetylcholinesterase 76
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 76
- Dimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A] 75
- NACHT, LRR and PYD domains-containing protein 3 72
- C-X-C chemokine receptor type 3 71
- Similar to alpha-tubulin isoform 1 71
- Histone deacetylase 69
- Peroxisome proliferator-activated receptor gamma 69
- Cytochrome P450 2D6 67
- Polyphenol oxidase 2 65
- Tyrosine-protein phosphatase non-receptor type 11 64
- D-3-phosphoglycerate dehydrogenase 63
- Muscarinic acetylcholine receptor M2 62
- Muscarinic acetylcholine receptor M1 62
- BDNF/NT-3 growth factors receptor 61
- NT-3 growth factor receptor 60
- Serine/threonine-protein kinase mTOR 59
- Serine/threonine-protein kinase B-raf 58
- Cytochrome P450 2C9 55
- Corticotropin-releasing factor receptor 2 55
- Corticotropin-releasing factor receptor 1 55
- Histone deacetylase 6 53
- Proto-oncogene tyrosine-protein kinase Src 52
- Polyunsaturated fatty acid lipoxygenase ALOX15 51
- Isocitrate dehydrogenase [NADP] cytoplasmic 51
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 51
- Insulin-like growth factor 1 receptor 51
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 51
- Beta-galactosidase 50
- ALK tyrosine kinase receptor 50
- Insulin receptor 50
- Tyrosine-protein kinase Tec 48
- Cytochrome P450 2C19 48
- Vascular endothelial growth factor receptor 2 47
- Xanthine dehydrogenase/oxidase 44
- Serine/threonine-protein kinase ATR 44
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 41
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 41
- Histone deacetylase 8 41
- Histone-lysine N-methyltransferase EZH2 41
- Gag-Pol polyprotein [489-587] 40
- ...
Publications 50▿
- US Patent US10562878 (2020) 1149
- US Patent US9763922 (2017) 595
- J Med Chem 62: 7923-7940 (2019) 302
- J Med Chem 59: 5488-504 (2016) 186
- US Patent US11247989 (2022) 174
- J Med Chem 59: 10549-10563 (2016) 167
- J Med Chem 66: 4025-4044 (2023) 167
- J Med Chem 48: 1107-31 (2005) 164
- Bioorg Med Chem Lett 18: 5481-6 (2008) 162
- J Med Chem 63: 15541-15563 (2020) 157
- Bioorg Med Chem 19: 663-76 (2011) 154
- J Med Chem 59: 4948-64 (2016) 149
- J Med Chem 62: 11232-11259 (2019) 148
- J Med Chem 65: 2035-2058 (2022) 143
- US Patent US11168070 (2021) 125
- US Patent US10696655 (2020) 125
- Bioorg Med Chem Lett 28: 85-93 (2018) 121
- J Med Chem 62: 3254-3267 (2019) 121
- Bioorg Med Chem Lett 28: 15-23 (2018) 115
- US Patent US11034698 (2021) 115
- J Med Chem 48: 262-5 (2005) 110
- ACS Med Chem Lett 5: 921-6 (2014) 108
- Bioorg Med Chem Lett 21: 1438-41 (2011) 108
- J Med Chem 59: 1455-70 (2016) 108
- J Med Chem 55: 1511-25 (2012) 101
- Bioorg Med Chem Lett 21: 1434-7 (2011) 99
- Bioorg Med Chem Lett 18: 4798-801 (2008) 97
- J Med Chem 60: 9162-9183 (2017) 93
- Chem Biol Drug Des 86: 1323-9 (2015) 92
- J Med Chem 60: 4023-4035 (2017) 83
- Bioorg Med Chem Lett 19: 114-8 (2008) 80
- J Med Chem 61: 6779-6800 (2018) 79
- Bioorg Med Chem Lett 25: 4664-71 (2015) 77
- J Med Chem 44: 2719-34 (2001) 76
- J Agric Food Chem 58: 2643-51 (2010) 73
- Bioorg Med Chem Lett 19: 1686-90 (2009) 73
- Eur J Med Chem 232: (2022) 72
- US Patent US20230339882 (2023) 71
- J Med Chem 46: 49-63 (2002) 70
- Eur J Med Chem 182: (2019) 70
- Eur J Med Chem 228: (2022) 70
- Bioorg Med Chem Lett 17: 3864-7 (2007) 69
- J Med Chem 61: 5623-5642 (2018) 68
- J Med Chem 56: 1878-93 (2013) 68
- Eur J Med Chem 224: (2021) 67
- J Med Chem 56: 7025-48 (2013) 67
- J Med Chem 60: 10151-10171 (2017) 65
- Bioorg Med Chem 62: (2022) 65
- J Med Chem 62: 1577-1592 (2019) 64
- Bioorg Med Chem Lett 26: 677-83 (2016) 64
- ...
Institutions 28▿
- Genentech 1459
- Sunovion Pharamceuticals 1149
- TBA 591
- Glaxosmithkline 505
- Sichuan University 323
- West China Hospital of Sichuan University 269
- Wyeth Research 234
- Nanjing University 233
- Sunovion Pharmaceuticals 207
- The Beatson Institute For Cancer Research 169
- Beigene (Beijing) Co. 167
- Sepracor 154
- Ariad Pharmaceuticals 149
- Vanderbilt University 148
- Bristol-Myers Squibb 121
- Wuxi Apptec 115
- Procter & Gamble Pharmaceuticals 110
- Xuanzhu Pharma 108
- Merck Research Laboratories 97
- Pfizer 79
- Wyeth-Ayerst Research 76
- Central China Normal University 73
- Betta Pharmaceuticals 71
- School of Traditional Chinese Pharmacy 70
- Shanghai University of Traditional Chinese Medicine 70
- Astrazeneca 67
- National Clinical Research Center For Geriatrics 67
- California Institute of Technology 65
- ...
Affinity: 0.0012 to 2.6E+7 nM▿
- Ki 1009
- IC50 8813
- Kd 336
- EC50 607
- Affinity ≤ nM
Xtal structures: 200
Docked structures: 44
Catalog Cmpds: 400