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Found 15942 with Last Name = 'wang' and Initial = 'p'
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50100528(CHEMBL3327081)
Affinity DataKi: <0.0200nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50100535(CHEMBL3327073)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rattus norvegicus (Rat))
Georgetown University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0250nMAssay Description:Binding affinity towards rat forebrain nicotinic acetylcholine receptor using [3H]EB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rattus norvegicus (Rat))
Georgetown University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0250nMAssay Description:Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rattus norvegicus (Rat))
Georgetown University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0260nMAssay Description:Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rattus norvegicus (Rat))
Georgetown University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0260nMAssay Description:Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rattus norvegicus (Rat))
Georgetown University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50143281(3-((S)-Azetidin-2-yloxy)-5-iodo-pyridine | CHEMBL5...)
Affinity DataKi:  0.0310nMAssay Description:Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Georgetown University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50143281(3-((S)-Azetidin-2-yloxy)-5-iodo-pyridine | CHEMBL5...)
Affinity DataKi:  0.0620nMAssay Description:Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Georgetown University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0630nMAssay Description:Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Georgetown University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0630nMAssay Description:Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rattus norvegicus (Rat))
Georgetown University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50049750((S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Az...)
Affinity DataKi:  0.0740nMAssay Description:Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Georgetown University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50049750((S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Az...)
Affinity DataKi:  0.140nMAssay Description:Binding affinity of the compound was determined against Nicotinic acetylcholine receptor using [3H]-(-)-nicotine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rattus norvegicus (Rat))
Georgetown University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.150nMAssay Description:Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rattus norvegicus (Rat))
Georgetown University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.160nMAssay Description:Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50100521(CHEMBL3327078 | US10377744, Compound No. 2696)
Affinity DataKi:  0.190nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50100519(CHEMBL3327067 | US10377744, Compound No. 2391)
Affinity DataKi:  0.220nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50100531(CHEMBL3325465)
Affinity DataKi:  0.230nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rattus norvegicus (Rat))
Georgetown University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50049750((S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Az...)
Affinity DataKi:  0.240nMAssay Description:Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta2 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50100520(CHEMBL3327077 | US10377744, Compound No. 2422 | US...)
Affinity DataKi:  0.310nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50100534(CHEMBL3327074)
Affinity DataKi:  0.360nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50100541(CHEMBL3327066)
Affinity DataKi:  0.370nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rattus norvegicus (Rat))
Georgetown University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50143281(3-((S)-Azetidin-2-yloxy)-5-iodo-pyridine | CHEMBL5...)
Affinity DataKi:  0.420nMAssay Description:Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50100539(CHEMBL3327069)
Affinity DataKi:  0.430nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50100522(CHEMBL3327087)
Affinity DataKi:  0.440nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Georgetown University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.480nMAssay Description:Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta2 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Georgetown University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.480nMAssay Description:Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50100542(CHEMBL3327065)
Affinity DataKi:  0.490nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50100540(CHEMBL3327068)
Affinity DataKi:  0.490nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50327846(1-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-3-(4-(t...)
Affinity DataKi:  0.550nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260067(CHEMBL4078267 | US9957263, Example 78)
Affinity DataKi:  0.600nMAssay Description:Inhibition of recombinant human His6-tagged BRD4 bromodomain 2 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells preincubated for 30 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260083(CHEMBL4104956)
Affinity DataKi:  0.600nMAssay Description:Inhibition of His-tagged BRD4 bromodomain 1 (K57 to E168 residues) (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50100518(CHEMBL3327064 | US10377744, Compound No. 2389)
Affinity DataKi:  0.660nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260067(CHEMBL4078267 | US9957263, Example 78)
Affinity DataKi:  0.900nMAssay Description:Inhibition of His-tagged BRD4 bromodomain 1 (K57 to E168 residues) (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50327809(1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluorometho...)
Affinity DataKi:  0.910nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50526945(CHEMBL4473806)
Affinity DataKi:  0.960nMAssay Description:Competitive inhibition of human Glyoxalase-1 using GSH and MGO as substrate by Michaelis-Menten analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50100523(CHEMBL3327086)
Affinity DataKi:  0.980nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50100532(CHEMBL3327076)
Affinity DataKi:  0.990nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50526943(CHEMBL4436073)
Affinity DataKi:  1nMAssay Description:Competitive inhibition of human Glyoxalase-1 using GSH and MGO as substrateMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260084(CHEMBL4096313 | US9957263, Example 110)
Affinity DataKi:  1.10nMAssay Description:Inhibition of BRD4 in human HepG2 cells assessed as upregulation of ApoA1 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Nankai University

LigandPNGBDBM108220(5-(hydroxymethyl)-2-[3-(4-methoxyphenyl)propyl]- 5...)
Affinity DataKi:  1.17nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50100525(CHEMBL3327084)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human Glyoxalase-1 using GSH and MGO as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50100538(CHEMBL3327070)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50100537(CHEMBL3327071)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50100533(CHEMBL3327075)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50335967(1-(1-(isopropylsulfonyl)piperidin-4-yl)-3-(4-(trif...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260065(CHEMBL4088597 | US9957263, Example 63)
Affinity DataKi:  1.30nMAssay Description:Inhibition of His-tagged BRD4 bromodomain 1 (K57 to E168 residues) (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50260065(CHEMBL4088597 | US9957263, Example 63)
Affinity DataKi:  1.30nMAssay Description:Inhibition of His-epitope tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) using biotinylated histone H4 as substrate after 1 hr by Al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rattus norvegicus (Rat))
Georgetown University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50143282((-)-cytisine | (1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-m...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity of the compound was determined against Nicotinic acetylcholine receptor using [3H]-(-)-nicotine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human full-length recombinant PARP-1More data for this Ligand-Target Pair
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