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TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18040(4-amino-N-{2-[2-({2-amino-6-ethyl-5-[4-(3-methoxyp...)
Affinity DataKd:  270nMAssay Description:Binding affinity to human recombinant renin by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18041(N-[2-({2-amino-6-ethyl-5-[4-(3-methoxypropyl)-2,2-...)
Affinity DataKd:  79nMAssay Description:Binding affinity to human recombinant renin by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
LigandPNGBDBM50027797(4-(8-Amino-2-methyl-1,2,3,4-tetrahydro-isoquinolin...)
Affinity DataEC50:  2.88E+3nMAssay Description:Effective concentration that gives maximal stimulation of cyclic AMP production over the concentration range tested.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50367174(CHEMBL1788237)
Affinity DataEC50:  1.87E+3nMAssay Description:Effective concentration that gives maximal stimulation of cyclic AMP production over the concentration range tested.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM55121(cid_65340 | Dopamine | SMR000059081 | 4-(2-aminoet...)
Affinity DataEC50:  3.50E+3nMAssay Description:Effective concentration that gives maximal stimulation of cyclic AMP production over the concentration range tested.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50427041(CHEMBL2322210)
Affinity DataKd: >5.00E+5nMAssay Description:Binding affinity to human recombinant renin by NMR titration analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50427042(CHEMBL2322211)
Affinity DataKd: >5.00E+5nMAssay Description:Binding affinity to human recombinant renin by NMR titration analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330345(N-(2-(7-(((3R,4R)-4-(4-(3-(2-methoxybenzyloxy)prop...)
Affinity DataIC50: 0.0390nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330350((R)-3-((3S,4R,5R)-4-(4-(3-(2-methoxybenzyloxy)prop...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18012(trans,trans-4-arylpiperidine-based compound, 1)
Affinity DataIC50: 0.0670nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330354(6-(((R)-1-(4-(3-(2-methoxybenzyloxy)propoxy)phenyl...)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330355((1R,5S)-N-cyclopropyl-7-(4-(2-(2,6-dichloro-4-meth...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM98679(US8497286, 155)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM98684(US8497286, 160)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM98678(US8497286, 154)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50077699(7-((3R,4R)-4-{4-[3-(2-Methoxy-benzyloxy)-propoxy]-...)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330352(N-(2-(7-(((R)-1-(4-(3-(2-methoxybenzyloxy)propoxy)...)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330360(N-((2S,4S,5S,7S)-7-(2-(1-acetylpiperidin-4-yl)ethy...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054540(CHEMBL3318939)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054632(CHEMBL3318940)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259465((1R,5S)-7-{4-[3-(2-Chloro-3,6-difluoro-phenoxy)-pr...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054636(CHEMBL3318937)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054637(CHEMBL3318938)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054633(CHEMBL3318941)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM98679(US8497286, 155)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant renin in presence of human plasma using Ac- IHPFHL-VIHNK-(DY-505-X5)-COOH substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330351(N-(2-(7-(((R)-1-(4-(3-(2-methoxybenzyloxy)propoxy)...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17944(methyl N-[(3R)-1-[(5S,6S,8S)-5-amino-8-(butylcarba...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330345(N-(2-(7-(((3R,4R)-4-(4-(3-(2-methoxybenzyloxy)prop...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17950(CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM98686(US8497286, 162)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM98684(US8497286, 160)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant renin in presence of human plasma using Ac- IHPFHL-VIHNK-(DY-505-X5)-COOH substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM98678(US8497286, 154)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant renin in presence of human plasma using Ac- IHPFHL-VIHNK-(DY-505-X5)-COOH substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330340((1R,5S)-N-cyclopropyl-N-(3-methoxy-2-methylbenzyl)...)
Affinity DataIC50: 0.620nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330353(6-(((R)-1-(4-(3-(2-methoxybenzyloxy)propoxy)phenyl...)
Affinity DataIC50: 0.680nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330343((R)-methyl 1-((5S,6S,8R)-5-amino-9-(butylamino)-6-...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17996(N-{2-[(2S)-6-(2,4-diamino-6-ethylpyrimidin-5-yl)-2...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305452(methyl 2-((R)-(3-chlorophenyl)((R)-1-((S)-1-cycloh...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054634(CHEMBL3318942)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM98685(US8497286, 161)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM98673(US8497286, 149)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330344((2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydroxy-2,7...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17949((2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-{[4-meth...)
Affinity DataIC50: 1nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM25400(cid_657378 | CPA | CHEMBL68738 | (2R,3R,4S,5R)-2-[...)
Affinity DataIC50: 1nMAssay Description:Concentration required for 50% inhibition of [3H]-CHA binding on rat brain adenosine A1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054636(CHEMBL3318937)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant renin in presence of human plasma using Ac- IHPFHL-VIHNK-(DY-505-X5)-COOH substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054633(CHEMBL3318941)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant renin in presence of human plasma using Ac- IHPFHL-VIHNK-(DY-505-X5)-COOH substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM98673(US8497286, 149)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant renin in presence of human plasma using Ac- IHPFHL-VIHNK-(DY-505-X5)-COOH substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330362((1R,5S)-N-cyclopropyl-N-((2-methoxy-3-methylpyridi...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330346(4-((3S,4R,5R)-3-(methoxymethyl)-5-(naphthalen-2-yl...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant renin in bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054637(CHEMBL3318938)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant renin in presence of human plasma using Ac- IHPFHL-VIHNK-(DY-505-X5)-COOH substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
TargetRenin(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054540(CHEMBL3318939)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant renin in presence of human plasma using Ac- IHPFHL-VIHNK-(DY-505-X5)-COOH substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2016
Entry Details Article
PubMed
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