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TargetOrotidine 5'-phosphate decarboxylase(Baker's yeast)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50199178(1-beta-D-ribofuranosyl(3H)pyrimidine-2,4,6-trione ...)
Affinity DataKi:  0.00880nMAssay Description:Inhibition of Saccharomyces cerevisia uridine 5'-monophosphate synthaseMore data for this Ligand-Target Pair
TargetOrotidine 5'-phosphate decarboxylase(Baker's yeast)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50199178(1-beta-D-ribofuranosyl(3H)pyrimidine-2,4,6-trione ...)
Affinity DataKi:  0.00900nM ΔG°:  -63.0kJ/moleT: 25°CAssay Description:Inhibition of Saccharomyces cerevisia uridine 5'-monophosphate synthase after overnight incubation at room temperature by VP-ITC microcalorimetryMore data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Human)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23334(3-(pyridin-3-yl)propyl (2S)-1-(3,3-dimethyl-2-oxop...)
Affinity DataKi:  0.0100nMAssay Description:Ability to inhibit peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0250nMAssay Description:Tested for binding affinity against Nicotinic acetylcholine receptor alpha2-beta2More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0250nMAssay Description:Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 using [3H]epibatidineMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0350nMAssay Description:Tested for binding affinity against Nicotinic acetylcholine receptor alpha3-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0350nMAssay Description:Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0350nMAssay Description:Binding affinity towards Nicotinic acetylcholine receptor alpha3-beta4 using [3H]epibatidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Human)
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50277100(4-(3-Piperidin-1-yl-propoxy)-benzoic acid 2-{4-[3-...)
Affinity DataKi:  0.0420nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 4(Human)
Synaptic Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM82286(CAS_59763-91-6 | PP, human | PP,SALMON)
Affinity DataKi:  0.0500nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0610nMAssay Description:Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0610nMAssay Description:Tested for binding affinity against Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0610nMAssay Description:Binding affinity towards nicotinic acetylcholine receptor alpha2-beta2 using [3H]epibatidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 4(Human)
Synaptic Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM82297(CAS_59763-91-6 | PP, BOVINE)
Affinity DataKi:  0.0700nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 4(Human)
Synaptic Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM82294(PP2-36, HUMAN)
Affinity DataKi:  0.0800nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Human)
Synaptic Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50015490(CHEMBL438945 | H-YPSKPDNPGEDAPAEDMARYYSALRHYINLITR...)
Affinity DataKi:  0.0800nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 4(Human)
Synaptic Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM82289(I31,G34-PP,human)
Affinity DataKi:  0.0900nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Human)
Synaptic Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50005530(CHEMBL267633 | D-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-G...)
Affinity DataKi:  0.0900nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Human)
Synaptic Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50015490(CHEMBL438945 | H-YPSKPDNPGEDAPAEDMARYYSALRHYINLITR...)
Affinity DataKi:  0.0900nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Human)
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50278350(4-fluoro-1-(4-(3-(piperidin-1-yl)propoxy)benzyl)pi...)
Affinity DataKi:  0.0933nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK293 cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Human)
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50278350(4-fluoro-1-(4-(3-(piperidin-1-yl)propoxy)benzyl)pi...)
Affinity DataKi:  0.0940nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK293 cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-4(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0950nMAssay Description:Tested for binding affinity against Nicotinic acetylcholine receptor alpha2-beta4More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-4(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0950nMAssay Description:Binding affinity towards Nicotinic acetylcholine receptor alpha2-beta4 using [3H]epibatidineMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 4(Human)
Synaptic Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM82291(P34-PYY,human)
Affinity DataKi:  0.110nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Mouse)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50133235(CHEMBL132720 | Docosanedioic acid ((S)-5-hydroxyme...)
Affinity DataKi:  0.110nMAssay Description:Tested for ability to displace [20e3] phorbol 12,13- dibutyrate binding from recombinant C1b domain of murine Protein kinase C delta in presence of [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM4779(CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib ...)
Affinity DataKi:  0.110nMAssay Description:Reversible binding affinity to human EGFR L858R/ T790M double mutant expressed in baculovirus by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Human)
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50392759(CHEMBL2151157)
Affinity DataKi:  0.126nMAssay Description:Displacement of [3H]N-alpha-Methylhistamine from human recombinant H3 receptor expressed in HEK293 cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Human)
Synaptic Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM82421(CAS_81858-94-8 | PYY, porcine)
Affinity DataKi:  0.140nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Human)
Synaptic Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM82299(PYY Pro34, Human)
Affinity DataKi:  0.140nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Mouse)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50133238(CHEMBL334853 | Hexadecanedioic acid ((S)-5-hydroxy...)
Affinity DataKi:  0.140nMAssay Description:Tested for ability to displace [20e3] phorbol 12,13- dibutyrate binding from recombinant C1b domain of murine Protein kinase C delta in presence of [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Human)
Synaptic Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM82291(P34-PYY,human)
Affinity DataKi:  0.140nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.157nMAssay Description:Binding affinity towards nicotinic acetylcholine receptor alpha2-beta2 using [3H]epibatidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.157nMAssay Description:Tested for binding affinity against Nicotinic acetylcholine receptor alpha4-beta4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Human)
Synaptic Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM82276(L31,P34-NPY,human | NPY Leu31, Pro34, human, rat |...)
Affinity DataKi:  0.160nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Human)
Synaptic Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM82286(CAS_59763-91-6 | PP, human | PP,SALMON)
Affinity DataKi:  0.160nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Human)
Synaptic Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM82279(CAS_118997-30-1 | PYY, human)
Affinity DataKi:  0.170nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Human)
Synaptic Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM82279(CAS_118997-30-1 | PYY, human)
Affinity DataKi:  0.170nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Human)
Synaptic Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM82279(CAS_118997-30-1 | PYY, human)
Affinity DataKi:  0.170nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 4(Human)
Synaptic Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM82300(CAS_59763-91-6 | NSC_41735 | PP, rat)
Affinity DataKi:  0.180nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Human)
Long Island University

Curated by ChEMBL
LigandPNGBDBM50050513((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...)
Affinity DataKi:  0.180nMAssay Description:Binding affinity to DPP-4 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistamine H3 receptor(Human)
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50013722(CHEMBL3264546)
Affinity DataKi:  0.229nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK293 cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50162983(6-[5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-pyridin-3-yl]...)
Affinity DataKi:  0.230nMAssay Description:Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Human)
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50001752(CHEMBL3238445)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human H3 receptor expressed in HEK-293 cell membrane after 90 mins by liquid scintillation counting ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Human)
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50277045(CHEMBL459350 | [3-(10,11-Dihydro-dibenzo[a,d]cyclo...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

LigandPNGBDBM420298(CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...)
Affinity DataKi:  0.270nMAssay Description:The respective human coronavirus Mpro in assay buffer (20 mM Tris-HCl, pH 7.3, 100 mM NaCl, 1 mM EDTA, 5 mM TCEP) and 0.1% BSA was added to assay-rea...More data for this Ligand-Target Pair
Ligand InfoPurchasePDB
In DepthDetails
TargetAlpha-2B adrenergic receptor(Human)
Neurogenetic

Curated by PDSP Ki Database
LigandPNGBDBM50013515((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Affinity DataKi:  0.320nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein kinase C delta type(Mouse)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50133236(CHEMBL337834 | Tetradecanedioic acid ((S)-5-hydrox...)
Affinity DataKi:  0.330nMAssay Description:Tested for ability to displace [20e3] phorbol 12,13- dibutyrate binding from recombinant C1b domain of murine Protein kinase C delta in presence of [...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Human)
Synaptic Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM82421(CAS_81858-94-8 | PYY, porcine)
Affinity DataKi:  0.350nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Human)
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50277046(CHEMBL517244 | methyl({4-[3-(piperidin-1-yl)propox...)
Affinity DataKi:  0.358nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Mouse)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50133238(CHEMBL334853 | Hexadecanedioic acid ((S)-5-hydroxy...)
Affinity DataKi:  0.360nMAssay Description:Tested for ability to displace [20e3] phorbol 12,13- dibutyrate binding from recombinant murine Protein kinase C delta in presence of [Ca2+]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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