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TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002087(4-(1-Methyl-piperidin-4-ylidene)-4,9-dihydro-1-thi...)
Affinity DataKi:  0.158nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416668(CHEMBL1222552)
Affinity DataKi:  0.631nMAssay Description:Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412984(CHEMBL458002)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416668(CHEMBL1222552)
Affinity DataKi:  3.16nMAssay Description:Antagonist activity at human adrenergic Alpha-1B receptor assessed as intracellular calcium luminescence by cell based aequorin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412984(CHEMBL458002)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]mesulergine from 5HT2C receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417376(CHEMBL1278116)
Affinity DataKi:  3.98nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416668(CHEMBL1222552)
Affinity DataKi:  3.98nMAssay Description:Antagonist activity at human adrenergic alpha1A receptor assessed as intracellular calcium luminescence by cell based aequorin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330747((-)-1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'...)
Affinity DataKi:  4.68nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330752(3-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataKi:  5.37nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330751(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataKi:  5.62nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412987(CHEMBL475965)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330751(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataKi:  6.31nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416668(CHEMBL1222552)
Affinity DataKi:  7.94nMAssay Description:Antagonist activity at human 5HT2A receptor expressed in HEK cells assessed as intracellular calcium luminescence by aequorin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330748(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataKi:  8.71nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417355(CHEMBL1278114)
Affinity DataKi:  10nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330753(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataKi:  12.3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416674(CHEMBL1222626)
Affinity DataKi:  12.6nMAssay Description:Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417365(CHEMBL1278202)
Affinity DataKi:  12.6nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416674(CHEMBL1222626)
Affinity DataKi:  12.6nMAssay Description:Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330749(1-(11'H-Spiro[cyclopentane-1,10'-dibenzo[b,f]oxepi...)
Affinity DataKi:  14.1nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417373(CHEMBL1278020)
Affinity DataKi:  15.8nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416676(CHEMBL1222693)
Affinity DataKi:  15.8nMAssay Description:Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417366(CHEMBL1278201)
Affinity DataKi:  15.8nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330750(CHEMBL1277126)
Affinity DataKi:  19.9nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330748(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataKi:  19.9nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417369(CHEMBL1277584)
Affinity DataKi:  19.9nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416668(CHEMBL1222552)
Affinity DataKi:  19.9nMAssay Description:Antagonist activity at human 5HT2C receptor expressed in human SHSY5Y cells by FLPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416672(CHEMBL1222624)
Affinity DataKi:  19.9nMAssay Description:Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412988(CHEMBL477008)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330748(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataKi:  20nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416670(CHEMBL1222554)
Affinity DataKi:  25.1nMAssay Description:Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416679(CHEMBL1222762)
Affinity DataKi:  25.1nMAssay Description:Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417370(CHEMBL1277585)
Affinity DataKi:  25.1nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417375(CHEMBL1278115)
Affinity DataKi:  25.1nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412983(CHEMBL458001)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]mesulergine from 5HT2C receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412984(CHEMBL458002)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416677(CHEMBL1222694)
Affinity DataKi:  31.6nMAssay Description:Antagonist activity at human 5HT2C receptor expressed in human SHSY5Y cells by FLPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330752(3-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataKi:  31.6nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417364(CHEMBL1276859)
Affinity DataKi:  31.6nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416673(CHEMBL1222625)
Affinity DataKi:  31.6nMAssay Description:Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416675(CHEMBL1222692)
Affinity DataKi:  39.8nMAssay Description:Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416680(CHEMBL1222763)
Affinity DataKi:  39.8nMAssay Description:Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416675(CHEMBL1222692)
Affinity DataKi:  39.8nMAssay Description:Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416672(CHEMBL1222624)
Affinity DataKi:  39.8nMAssay Description:Antagonist activity at human 5HT2A receptor expressed in HEK cells assessed as intracellular calcium luminescence by aequorin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417381(CHEMBL1277855)
Affinity DataKi:  39.8nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416676(CHEMBL1222693)
Affinity DataKi:  39.8nMAssay Description:Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417372(CHEMBL1277854)
Affinity DataKi:  39.8nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330753(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataKi:  39.8nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417363(CHEMBL1276860)
Affinity DataKi:  39.8nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416679(CHEMBL1222762)
Affinity DataKi:  39.8nMAssay Description:Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells by FLPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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