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TargetFatty acid-binding protein, intestinal(Human)
Monash University

LigandPNGBDBM153300(DAUDA)
Affinity DataKd:  360nMpH: 8.0 T: 2°CAssay Description:ITC experiments were carried out using an iTC200 microcalorimeter (MicroCal) with coin shaped sample cell (200 μL) at 37 C with stirring at 1000...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFatty acid-binding protein, intestinal(Human)
Monash University

LigandPNGBDBM60927(ANS | BDBM50126831 | 1-anilinonaphthalene-8-sulfon...)
Affinity DataKd:  1.33E+4nMpH: 8.0 T: 2°CAssay Description:ITC experiments were carried out using an iTC200 microcalorimeter (MicroCal) with coin shaped sample cell (200 μL) at 37 C with stirring at 1000...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details Article
PubMed
TargetFatty acid-binding protein, intestinal(Human)
Monash University

LigandPNGBDBM85511(Toradol | KETOROLAC | CAS_74103-07-4 | Ketorolac t...)
Affinity DataKd:  5.67E+4nMpH: 8.0 T: 2°CAssay Description:ITC experiments were carried out using an iTC200 microcalorimeter (MicroCal) with coin shaped sample cell (200 μL) at 37 C with stirring at 1000...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details Article
PubMed
TargetFatty acid-binding protein, intestinal(Human)
Monash University

LigandPNGBDBM50085042(Finofibrate | Tricor (TN) | CHEMBL672 | propan-2-y...)
Affinity DataKd:  4.41E+3nMpH: 8.0 T: 2°CAssay Description:ITC experiments were carried out using an iTC200 microcalorimeter (MicroCal) with coin shaped sample cell (200 μL) at 37 C with stirring at 1000...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details Article
PubMed
TargetFatty acid-binding protein, intestinal(Human)
Monash University

LigandPNGBDBM50099491(cid_3392731 | CHEMBL21241 | 2-(4-{2-[3-Cyclohexyl-...)
Affinity DataKd:  1.30E+3nMpH: 8.0 T: 2°CAssay Description:ITC experiments were carried out using an iTC200 microcalorimeter (MicroCal) with coin shaped sample cell (200 μL) at 37 C with stirring at 1000...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details Article
PubMed
TargetFatty acid-binding protein, intestinal(Human)
Monash University

LigandPNGBDBM50085041({4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]...)
Affinity DataKd:  7.20E+3nMpH: 8.0 T: 2°CAssay Description:ITC experiments were carried out using an iTC200 microcalorimeter (MicroCal) with coin shaped sample cell (200 μL) at 37 C with stirring at 1000...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details Article
PubMed
LigandPNGBDBM50112379(1-(3-Chloro-phenyl)-4-{2-[3-(2-methoxy-4'-trifluor...)
Affinity DataEC50:  3.40E+3nMAssay Description:Inhibition of geranylgeranylation of Rap1a in PSN-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50112383(17-(5,5,5-trifluoropentyl)-19-oxa-2,5,10,12-tetraa...)
Affinity DataEC50:  6.90nMAssay Description:Inhibition of HDJ2 farnesylation in PSN-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50112383(17-(5,5,5-trifluoropentyl)-19-oxa-2,5,10,12-tetraa...)
Affinity DataEC50:  800nMAssay Description:Inhibition of geranylgeranylation of Rap1a in PSN-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50112379(1-(3-Chloro-phenyl)-4-{2-[3-(2-methoxy-4'-trifluor...)
Affinity DataEC50:  28nMAssay Description:Inhibition of HDJ2 farnesylation in PSN-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50118702(CHEMBL1076 | Orvaten | 2-Amino-1-(2,5-dimethoxy-ph...)
Affinity DataEC50:  1.90E+3nMAssay Description:Effective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50118703(N-[5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,...)
Affinity DataEC50:  2.60E+3nMAssay Description:Effective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022722((1R, 2S)-2-Amino-1-phenyl-propan-1-ol | CHEMBL1365...)
Affinity DataEC50:  2.30E+5nMAssay Description:Effective concentration in vitro against rabbit urethra Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50118703(N-[5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,...)
Affinity DataEC50:  320nMAssay Description:Effective concentration in vitro against rat spleen Alpha-1B adrenergic receptor indicates EC50 < 15% at a concentration of 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022722((1R, 2S)-2-Amino-1-phenyl-propan-1-ol | CHEMBL1365...)
Affinity DataEC50:  5.80E+4nMAssay Description:Effective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50118703(N-[5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,...)
Affinity DataEC50:  9.30nMAssay Description:Effective concentration in vitro against rabbit urethra Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50118705(ABT-866 | N-[3-(1H-imidazol-4-ylmethyl)-phenyl]eth...)
Affinity DataEC50:  600nMAssay Description:Effective concentration in vitro against rabbit urethra Alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022722((1R, 2S)-2-Amino-1-phenyl-propan-1-ol | CHEMBL1365...)
Affinity DataEC50:  2.80E+5nMAssay Description:Effective concentration in vitro against rat spleen Alpha-1B adrenergic receptor indicates EC50 < 15% at a concentration of 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50118702(CHEMBL1076 | Orvaten | 2-Amino-1-(2,5-dimethoxy-ph...)
Affinity DataEC50:  7.10E+3nMAssay Description:Effective concentration in vitro against rabbit urethra Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50118702(CHEMBL1076 | Orvaten | 2-Amino-1-(2,5-dimethoxy-ph...)
Affinity DataEC50:  8.50E+4nMAssay Description:Effective concentration in vitro against rat spleen Alpha-1B adrenergic receptor indicates EC50 < 15% at a concentration of 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161668(1-Cyclopentylmethyl-1-(4-methanesulfonyl-phenyl)-3...)
Affinity DataEC50:  1.60E+4nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161669(1-Cyclopentylmethyl-1-(6-methoxy-pyridin-3-yl)-3-(...)
Affinity DataEC50:  2.91E+4nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161670(3-[3-(5-Chloro-thiazol-2-yl)-1-cyclopentylmethyl-u...)
Affinity DataEC50:  1.00E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161671(3-(5-Bromo-thiazol-2-yl)-1-(4-methanesulfonyl-phen...)
Affinity DataEC50:  2.41E+4nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161672(3-(5-Bromo-thiazol-2-yl)-1-cyclopentylmethyl-1-(6-...)
Affinity DataEC50:  2.00E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161673(1-Cyclopentylmethyl-1-(4-methanesulfonyl-phenyl)-3...)
Affinity DataEC50:  3.42E+4nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161674(3-Cyclopentyl-2-(4-methanesulfonyl-phenyl)-N-thiaz...)
Affinity DataEC50:  1.00E+3nMAssay Description:Effective concentration for glucokinase activation with 15 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161676(1-Cyclopentylmethyl-1-(3,4-difluoro-phenyl)-3-thia...)
Affinity DataEC50:  1.63E+4nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161677(4-[3-(5-Chloro-thiazol-2-yl)-1-cyclopentylmethyl-u...)
Affinity DataEC50:  1.80E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161675(3-(5-Chloro-thiazol-2-yl)-1-(4-methanesulfonyl-phe...)
Affinity DataEC50:  6.80E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161680(3-(5-Chloro-thiazol-2-yl)-1-furan-2-ylmethyl-1-(4-...)
Affinity DataEC50:  1.15E+4nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161681(3-(5-Chloro-thiazol-2-yl)-1-(6-cyano-pyridin-3-yl)...)
Affinity DataEC50:  7.70E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161682(3-(5-Chloro-thiazol-2-yl)-1-cyclopentylmethyl-1-(3...)
Affinity DataEC50:  1.40E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161678(3-(5-Chloro-thiazol-2-yl)-1-cyclopentylmethyl-1-(6...)
Affinity DataEC50:  2.70E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161679(3-(5-Chloro-thiazol-2-yl)-1-(4-cyano-phenyl)-1-cyc...)
Affinity DataEC50:  2.40E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161684(1-Cyclopentylmethyl-3-(6-methanesulfonyl-benzothia...)
Affinity DataEC50:  3.29E+4nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161685(1-Cyclopentylmethyl-1-(6-methoxy-pyridin-3-yl)-3-t...)
Affinity DataEC50:  1.92E+4nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161683(3-(5-Chloro-thiazol-2-yl)-1-(4-methanesulfonyl-phe...)
Affinity DataEC50:  4.90E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161674(3-Cyclopentyl-2-(4-methanesulfonyl-phenyl)-N-thiaz...)
Affinity DataEC50:  2.20E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161686(3-(5-Chloro-thiazol-2-yl)-1-cyclopentylmethyl-1-(4...)
Affinity DataEC50:  1.30E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161687(3-(5-Chloro-thiazol-2-yl)-1-cyclopentylmethyl-1-(4...)
Affinity DataEC50:  1.50E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161688(3-(5-Chloro-thiazol-2-yl)-1-(4-methanesulfonyl-phe...)
Affinity DataEC50:  6.60E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161689(3-(5-Chloro-thiazol-2-yl)-1-(4-methanesulfonyl-phe...)
Affinity DataEC50:  2.19E+4nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161690(3-(5-Chloro-thiazol-2-yl)-1-cyclopentylmethyl-1-(3...)
Affinity DataEC50:  2.60E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161691(N-{3-[3-(5-Chloro-thiazol-2-yl)-1-cyclopentylmethy...)
Affinity DataEC50:  300nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161694(3-(5-Bromo-thiazol-2-yl)-1-(4-methanesulfonyl-phen...)
Affinity DataEC50:  6.50E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161693(3-(5-Chloro-thiazol-2-yl)-1-(4-methanesulfonyl-phe...)
Affinity DataEC50:  2.16E+4nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161668(1-Cyclopentylmethyl-1-(4-methanesulfonyl-phenyl)-3...)
Affinity DataEC50:  9.70E+3nMAssay Description:Effective concentration for glucokinase activation with 15 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161695(1-(4-Bromo-3-fluoro-phenyl)-3-(5-chloro-thiazol-2-...)
Affinity DataEC50:  700nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161692(1-(3-Chloro-4-methyl-phenyl)-3-(5-chloro-thiazol-2...)
Affinity DataEC50:  400nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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