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TargetProstaglandin F2-alpha receptor(Mouse)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50247862(5Z-(9S,11R,15S)-13-Oxa-17-(3-trifluoromethyl)pheny...)
Affinity DataEC50:  1.90nMAssay Description:Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50150900((Z)-8-{(2R,3S,4R)-2-[(E)-(R)-4-(3-Chloro-phenoxy)-...)
Affinity DataEC50:  58nMAssay Description:Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Mouse)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50035622(l-Prostaglandin F2-alpha | (5Z,13E,15S)-9alpha,11a...)
Affinity DataEC50:  24.5nMAssay Description:Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50150893((Z)-8-{(2R,3S,4R)-4-Hydroxy-2-[(E)-(S)-3-hydroxy-4...)
Affinity DataEC50:  781nMAssay Description:Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50150895((Z)-7-[(2R,3S,4R)-4-Hydroxy-2-((E)-(R)-3-hydroxy-o...)
Affinity DataEC50: >1.00E+4nMAssay Description:Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50150897((Z)-8-[(2R,3S,4R)-4-Hydroxy-2-((E)-(S)-3-hydroxy-4...)
Affinity DataEC50:  252nMAssay Description:Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50150894((Z)-8-{(2R,3S,4R)-4-Hydroxy-2-[(E)-(R)-3-hydroxy-4...)
Affinity DataEC50:  187nMAssay Description:Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50150891((Z)-8-[(R)-4-Hydroxy-2-((1R,2S,4S)-3-hydroxy-4-phe...)
Affinity DataEC50:  573nMAssay Description:Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50150904((Z)-8-[(2R,3S,4R)-4-Hydroxy-2-((E)-(R)-3-hydroxy-4...)
Affinity DataEC50:  57nMAssay Description:Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50150906((E)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(E)-3-hydrox...)
Affinity DataEC50:  2.70nMAssay Description:Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50150902((Z)-8-[(2R,3S,4R)-4-Hydroxy-2-((E)-(R)-3-hydroxy-4...)
Affinity DataEC50:  293nMAssay Description:Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50394089(CHEMBL2158640)
Affinity DataEC50:  46nMAssay Description:Agonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50150898((Z)-8-{(2R,3S,4R)-2-[(E)-(R)-4-(3-Chloro-phenoxy)-...)
Affinity DataEC50:  23nMAssay Description:Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50150899(LATANOPROST (PHXA41) | CHEMBL364375 | Latanoprost ...)
Affinity DataEC50:  34.4nMAssay Description:Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50150896((Z)-8-{(2R,3S,4R)-2-[(E)-(S)-4-(3-Chloro-phenoxy)-...)
Affinity DataEC50:  249nMAssay Description:Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Mouse)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50247863(5Z-(9S,11R,15R)-13-Oxa-17-(3-trifluoromethyl)pheny...)
Affinity DataEC50:  5.70nMAssay Description:Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50150905((Z)-8-{(2R,3S,4R)-4-Hydroxy-2-[(E)-(S)-3-hydroxy-4...)
Affinity DataEC50:  899nMAssay Description:Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50020222(CHEMBL285755 | 7-Dipropylamino-5,6,7,8-tetrahydro-...)
Affinity DataEC50:  0.950nMAssay Description:Agonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Mouse)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50247918(5Z-(9S,11R,15S)-13-Oxa-16-(3-chloro)phenoxy-propox...)
Affinity DataEC50:  62.2nMAssay Description:Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50150903((Z)-7-[(2R,3S,4R)-4-Hydroxy-2-((E)-(S)-3-hydroxy-o...)
Affinity DataEC50:  2.38E+3nMAssay Description:Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM21221(2-Cl-IB-MECA | CHEMBL431733 | C-IBzA-MU | 2-chloro...)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Mouse)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50247915(5Z-(9S,11R,15R)-13-Oxa-16-phenoxy-propoxy]-9,11,15...)
Affinity DataEC50:  294nMAssay Description:Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50150901((Z)-8-{(2R,3S,4R)-2-[(E)-(S)-4-(3-Chloro-phenoxy)-...)
Affinity DataEC50:  194nMAssay Description:Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Mouse)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50423647(Latanoprost | PHXA-41 | PHXA41 | XA-41 | XA41 | Xa...)
Affinity DataEC50:  32nMAssay Description:Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Mouse)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50247916(5Z-(9S,11R,15R)-13-Oxa-16-(3-chloro)phenoxy-propox...)
Affinity DataEC50:  52.4nMAssay Description:Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50150892((Z)-8-{(2R,3S,4R)-4-Hydroxy-2-[(E)-(R)-3-hydroxy-4...)
Affinity DataEC50:  67nMAssay Description:Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Mouse)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50247917(5Z-(9S,11R,15S)-13-Oxa-16-phenoxy-propoxy]-9,11,15...)
Affinity DataEC50:  68.6nMAssay Description:Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50035622(l-Prostaglandin F2-alpha | (5Z,13E,15S)-9alpha,11a...)
Affinity DataEC50:  24.5nMAssay Description:Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50052278(5-[(2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-2...)
Affinity DataIC50: 0.0500nMAssay Description:Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50052280((2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-ph...)
Affinity DataIC50: 0.220nMAssay Description:Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50000041((+/-)(2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-...)
Affinity DataIC50: 0.5nMAssay Description:Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50052276((2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-1-(1...)
Affinity DataIC50: 0.530nMAssay Description:Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50052275(5-[(2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-2...)
Affinity DataIC50: 0.800nMAssay Description:Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50052282((2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-1-(1...)
Affinity DataIC50: 0.900nMAssay Description:Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50052281((2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-1-[1...)
Affinity DataIC50: 0.970nMAssay Description:Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50052274((2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-1-ox...)
Affinity DataIC50: 1nMAssay Description:Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50052283(2-[3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-phenyl-...)
Affinity DataIC50: 1.30nMAssay Description:Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016991(CHEMBL280055 | 7-Fluoro-2-(4-methoxy-benzyl)-3-met...)
Affinity DataIC50: 7nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(CHEMBL17815 | 7-Chloro-2-(4-methoxy-benzyl)-3-meth...)
Affinity DataIC50: 11nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016990(CHEMBL18394 | 2-(4-Methoxy-benzyl)-3,7-dimethyl-5-...)
Affinity DataIC50: 12nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50017001(CHEMBL18946 | 7-Chloro-2-(2,4-dimethoxy-benzyl)-3-...)
Affinity DataIC50: 13nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50017000(CHEMBL278034 | 5-Allyl-7-chloro-2-(4-methoxy-benzy...)
Affinity DataIC50: 20nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016987(CHEMBL18989 | 7-Chloro-2-(4-methoxy-benzyl)-3,5-di...)
Affinity DataIC50: 20nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016998(CHEMBL18694 | 7-Chloro-2-(4-chloro-benzyl)-3-methy...)
Affinity DataIC50: 26nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016994(CHEMBL18820 | 2-Benzyl-7-chloro-3-methyl-5-propyl-...)
Affinity DataIC50: 30nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016985(CHEMBL18050 | 2-(4-Methoxy-benzyl)-3-methyl-5-prop...)
Affinity DataIC50: 31nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(CHEMBL17815 | 7-Chloro-2-(4-methoxy-benzyl)-3-meth...)
Affinity DataIC50: 36nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50052277((2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-1-fu...)
Affinity DataIC50: 36nMAssay Description:Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50052279((2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-ph...)
Affinity DataIC50: 43nMAssay Description:Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016989(CHEMBL18250 | 7-Chloro-2-(4-methoxy-benzyl)-3,5-di...)
Affinity DataIC50: 46nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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