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TargetProtein kinase C alpha type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50099646(5,6-dihydroxy-7-hydroxymethyl-3,11,11,14-tetrameth...)
Affinity DataKi:  0.140nMAssay Description:Displacement of [3H]-PDBU from protein kinase C-alphaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C alpha type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50281601(13-butylcarbonyloxy-1,6-dihydroxy-8-hydroxymethyl-...)
Affinity DataKi:  0.540nMAssay Description:Displacement of [3H]-PDBU from protein kinase C-alphaMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM17468(1,2,3-triazole analogue, 24 | 5-(3,4-dibromophenyl...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17461(1,2,3-triazole analogue, 17 | 5-(4-iodophenyl)-1H-...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Human)
Glaxosmithkline

LigandPNGBDBM10323((S)-1-Benzyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]s...)
Affinity DataKi:  1.20nM IC50:  2.5nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17474(1,2,3-triazole analogue, 30 | 4-methyl-2-(1H-1,2,3...)
Affinity DataKi:  3nM ΔG°:  -48.2kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17460(1,2,3-triazole analogue, 16 | 5-(4-bromophenyl)-1H...)
Affinity DataKi:  3nM ΔG°:  -48.2kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17467(1,2,3-triazole analogue, 23 | 5-(3-bromophenyl)-1H...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17459(1,2,3-triazole analogue, 15 | 5-(4-chlorophenyl)-1...)
Affinity DataKi:  6nM ΔG°:  -46.5kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Human)
Glaxosmithkline

LigandPNGBDBM10323((S)-1-Benzyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]s...)
Affinity DataKi:  6nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17473(1,2,3-triazole analogue, 29 | 3-methyl-2-(1H-1,2,3...)
Affinity DataKi:  6nM ΔG°:  -46.5kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17475(1,2,3-triazole analogue, 31 | 5-methyl-2-(1H-1,2,3...)
Affinity DataKi:  8nM ΔG°:  -45.7kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17469(1,2,3-triazole analogue, 25 | 5-(1-benzofuran-2-yl...)
Affinity DataKi:  13nM ΔG°:  -44.6kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-3(Human)
Glaxosmithkline

LigandPNGBDBM10318((S)-5-{1-[2-(Phenoxymethyl)pyrrolidinyl]sulfonyl}i...)
Affinity DataKi:  15nM IC50:  44nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17447(1,2,3-triazole analogue, 3 | 5-(4-methylphenyl)-1H...)
Affinity DataKi:  15nM ΔG°:  -44.2kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17466(1,2,3-triazole analogue, 22 | 5-(3-iodophenyl)-1H-...)
Affinity DataKi:  16nM ΔG°:  -44.0kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM17462(1,2,3-triazole analogue, 18 | 5-(3-methylphenyl)-1...)
Affinity DataKi:  18nM ΔG°:  -43.8kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
TargetCaspase-3(Human)
Glaxosmithkline

LigandPNGBDBM10315((S)-5-{1-[2-(Anilinomethyl)pyrrolidinyl]sulfonyl}i...)
Affinity DataKi:  19nM IC50:  31nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17465(1,2,3-triazole analogue, 21 | N-benzyl-3-(1H-1,2,3...)
Affinity DataKi:  29nM ΔG°:  -42.6kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM17455(1,2,3-triazole analogue, 11 | 5-(4-ethylphenyl)-1H...)
Affinity DataKi:  30nM ΔG°:  -42.5kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17470(1,2,3-triazole analogue, 26 | 2-(1H-1,2,3-triazol-...)
Affinity DataKi:  41nM ΔG°:  -41.7kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Human)
Glaxosmithkline

LigandPNGBDBM10318((S)-5-{1-[2-(Phenoxymethyl)pyrrolidinyl]sulfonyl}i...)
Affinity DataKi:  47nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Human)
Glaxosmithkline

LigandPNGBDBM10315((S)-5-{1-[2-(Anilinomethyl)pyrrolidinyl]sulfonyl}i...)
Affinity DataKi:  47nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17449(1,2,3-triazole analogue, 5 | 1H,4H-indeno[1,2-d][1...)
Affinity DataKi:  52nM ΔG°:  -41.2kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM17476(1,2,3-triazole analogue, 32 | 2-methyl-6-(1H-1,2,3...)
Affinity DataKi:  52nM ΔG°:  -41.2kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Human)
Glaxosmithkline

LigandPNGBDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Affinity DataKi:  60nM ΔG°:  -41.9kJ/mole IC50:  120nMpH: 7.5 T: 30°CAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17448(1,2,3-triazole analogue, 4 | 5-phenyl-1H-1,2,3-tri...)
Affinity DataKi:  70nM ΔG°:  -40.4kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17452(1,2,3-triazole analogue, 8 | 5-(2-methylphenyl)-1H...)
Affinity DataKi:  112nM ΔG°:  -39.3kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM10323((S)-1-Benzyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]s...)
Affinity DataKi:  120nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Human)
Glaxosmithkline

LigandPNGBDBM10298(1-benzyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione |...)
Affinity DataKi:  130nM ΔG°:  -40.0kJ/mole IC50:  250nMpH: 7.5 T: 30°CAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17453(1,2,3-triazole analogue, 9 | 5-(2-methoxyphenyl)-1...)
Affinity DataKi:  150nM ΔG°:  -38.6kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50281600(7-hydroxymethyl-14-oxo-4-phenylcarbonyloxytricyclo...)
Affinity DataKi:  165nMAssay Description:Displacement of [3H]-PDBU from protein kinase C-alphaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-7(Human)
Glaxosmithkline

LigandPNGBDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Affinity DataKi:  170nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Human)
Glaxosmithkline

LigandPNGBDBM10298(1-benzyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione |...)
Affinity DataKi:  170nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50281602(4,5,6-trihydroxy-7-hydroxymethyl-3,11,11,14-tetram...)
Affinity DataKi:  240nMAssay Description:Displacement of [3H]-PDBU from protein kinase C-alphaMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM17471(1,2,3-triazole analogue, 27 | 3-(1H-1,2,3-triazol-...)
Affinity DataKi:  260nM ΔG°:  -37.2kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17464(1,2,3-triazole analogue, 20 | 3-(1H-1,2,3-triazol-...)
Affinity DataKi:  280nM ΔG°:  -37.0kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17450(4-(4-methylphenyl)-1H-pyrazole | pyrazole analogue...)
Affinity DataKi:  280nM ΔG°:  -37.0kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Human)
Glaxosmithkline

LigandPNGBDBM10297(1-methyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione |...)
Affinity DataKi:  290nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17463(1,2,3-triazole analogue, 19 | 3-(1H-1,2,3-triazol-...)
Affinity DataKi:  300nM ΔG°:  -36.9kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17458(1,2,3-triazole analogue, 14 | 4-(1H-1,2,3-triazol-...)
Affinity DataKi:  337nM ΔG°:  -36.6kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Human)
Glaxosmithkline

LigandPNGBDBM10297(1-methyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione |...)
Affinity DataKi:  500nM ΔG°:  -36.6kJ/mole IC50:  1.00E+3nMpH: 7.5 T: 30°CAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM10315((S)-5-{1-[2-(Anilinomethyl)pyrrolidinyl]sulfonyl}i...)
Affinity DataKi:  850nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17454(1,2,3-triazole analogue, 10 | 5-(2-phenylphenyl)-1...)
Affinity DataKi: >1.00E+3nM ΔG°: >-33.9kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17456(1,2,3-triazole analogue, 12 | 5-(4-propylphenyl)-1...)
Affinity DataKi: >1.00E+3nM ΔG°: >-33.9kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17457(1,2,3-triazole analogue, 13 | 4-(1H-1,2,3-triazol-...)
Affinity DataKi: >1.00E+3nM ΔG°: >-33.9kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17472(1,2,3-triazole analogue, 28 | 4-(1H-1,2,3-triazol-...)
Affinity DataKi: >1.00E+3nM ΔG°: >-33.9kJ/molepH: 7.5 T: 22°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Human)
Glaxosmithkline

LigandPNGBDBM10298(1-benzyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione |...)
Affinity DataKi:  1.00E+3nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Affinity DataKi:  1.10E+3nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM10318((S)-5-{1-[2-(Phenoxymethyl)pyrrolidinyl]sulfonyl}i...)
Affinity DataKi:  1.20E+3nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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