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TargetD(2) dopamine receptor(Rat)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50033383((S)-4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)m...)
Affinity DataKd:  0.0400nMAssay Description:Binding affinity against Dopamine receptor D2 in rat striatum using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50033383((S)-4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)m...)
Affinity DataKd:  1.5nMAssay Description:Binding affinity against 5-hydroxytryptamine 1D receptor beta using rabbit saphenous vein assay.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50033383((S)-4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)m...)
Affinity DataKd:  0.300nMAssay Description:Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50033383((S)-4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)m...)
Affinity DataKd:  1.80nMAssay Description:Binding affinity against 5-hydroxytryptamine 1 receptor using rabbit jugular vein assay in the absence of endotheliumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50033383((S)-4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)m...)
Affinity DataKd:  1.5nMAssay Description:Binding affinity against 5-hydroxytryptamine 1D receptor beta using rabbit saphenous vein assay.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetOxytocin receptor(Human)
Cardiovascular and Urogenital Centre of Excellence For Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50190528((2R)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihy...)
Affinity DataIC50: 3.70nMAssay Description:Agonist activity at human OTR expressed in CHO cells assessed as inhibition of oxytocin-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334942(1-{4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-in...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human CYP1A2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334936(N-cyclopentyl-2-{4-[3-(trifluoromethyl)-4,5,6,7-te...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human CYP2C9 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334935(1-{4-[1-(1-pyrrolidinylcarbonyl)cyclopropyl]phenyl...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human CYP2C9 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetOxytocin receptor(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50029649(L-371257 | 1-(1-(4-(1-acetylpiperidin-4-yloxy)-2-m...)
Affinity DataIC50: 640nMAssay Description:Compound was tested for displacement of 3[H] oxytocin from rat OT receptor (in vitro)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334936(N-cyclopentyl-2-{4-[3-(trifluoromethyl)-4,5,6,7-te...)
Affinity DataIC50: 700nMAssay Description:Inhibition of human CYP3A4 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetOxytocin receptor(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50113051(N-{5-[4-(2-Oxo-4H-benzo[d][1,3]oxazin-1-yl)-piperi...)
Affinity DataIC50: 744nMAssay Description:Compound was tested for displacement of 3[H] oxytocin from rat OT receptor (in vitro)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50313618(1-(3-chlorophenyl)-3-(piperidin-2-ylmethyl)imidazo...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant CYP2D6 by spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50372613(CHEMBL410420)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334940(1-{4-[1-methyl-2-oxo-2-(1-pyrrolidinyl)ethyl]pheny...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CYP2C9 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334939(1-({4-[3-(Trifluoromethyl)-4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CYP1A2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334948(N-methyl-N-(2-phenylethyl)-4-[3-(trifluoromethyl)-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CYP2C9 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334937(1-({2-Fluoro-4-[3-(trifluoromethyl)-4,5,6,7-tetrah...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human CYP1A2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334947(N,N-dimethyl-4-[3-(trifluoromethyl)-4,5,6,7-tetrah...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human CYP2C9 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334949(1-{4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-in...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human CYP2C19 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50190529((2R)-2-(1-benzofuran-5-yl)-2-[(3R,6R)-3-(2,3-dihyd...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of CYP450 3A4 transfected in human microsome using DEF fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50372609(CHEMBL401960)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334946(1-{4-[2-OXO-2-(1-PYRROLIDINYL)ETHYL]PHENYL}-3-( TR...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human CYP2C9 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334948(N-methyl-N-(2-phenylethyl)-4-[3-(trifluoromethyl)-...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human CYP2C19 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetOxytocin receptor(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50113050(N-{5-[4-(2-Oxo-4H-benzo[d][1,3]oxazin-1-yl)-piperi...)
Affinity DataIC50: 3.04E+3nMAssay Description:Compound was tested for displacement of 3[H] oxytocin from rat OT receptor (in vitro)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50190529((2R)-2-(1-benzofuran-5-yl)-2-[(3R,6R)-3-(2,3-dihyd...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of CYP450 2C9 transfected in human microsomeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334938(N-({4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human CYP1A2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50372611(CHEMBL196478)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334945(1-{4-[1,1-difluoro-2-oxo-2-(1-pyrrolidinyl)ethyl]p...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human CYP2C9 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334941(1-(4-(methylsulfonyl)phenyl)-3-(trifluoromethyl)-4...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human CYP1A2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334942(1-{4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-in...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human CYP2C9 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50190529((2R)-2-(1-benzofuran-5-yl)-2-[(3R,6R)-3-(2,3-dihyd...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of CYP450 3A4 transfected in human microsome using PPR fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334939(1-({4-[3-(Trifluoromethyl)-4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human CYP2C9 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50190528((2R)-2-(2,4-difluorophenyl)-2-[(3R,6R)-3-(2,3-dihy...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human CYP3A4 using diethoxyfluorescein as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334932(N-butyl-N-methyl-4-[3-(trifluoromethyl)-4,5,6,7-te...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human CYP2C9 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334935(1-{4-[1-(1-pyrrolidinylcarbonyl)cyclopropyl]phenyl...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human CYP3A4 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334940(1-{4-[1-methyl-2-oxo-2-(1-pyrrolidinyl)ethyl]pheny...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human CYP1A2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50334950(N,N-Dimethyl-4-[3-(trifluoromethyl)-4,5,6,7-tetrah...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human CYP2D6 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50334941(1-(4-(methylsulfonyl)phenyl)-3-(trifluoromethyl)-4...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human CYP2D6 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50334943(1-[4-(1-Pyrrolidinylcarbonyl)phenyl]-3-(trifluorom...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human CYP2D6 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50372614(CHEMBL209864)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334944(1-{3-Fluoro-4-[2-oxo-2-(1-pyrrolidinyl)ethyl]pheny...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human CYP2C9 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334931(N,N-Dimethyl-2-{4-[3-(trifluoromethyl)-4,5,6,7-tet...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human CYP2C9 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334935(1-{4-[1-(1-pyrrolidinylcarbonyl)cyclopropyl]phenyl...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human CYP2C19 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50313618(1-(3-chlorophenyl)-3-(piperidin-2-ylmethyl)imidazo...)
Affinity DataIC50: 7.94E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334938(N-({4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-i...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human CYP2C9 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334929(1-({4-[3-(Trifluoromethyl)-6,7-dihydropyrano[4,3-c...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human CYP2C19 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334929(1-({4-[3-(Trifluoromethyl)-6,7-dihydropyrano[4,3-c...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human CYP3A4 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334929(1-({4-[3-(Trifluoromethyl)-6,7-dihydropyrano[4,3-c...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human CYP1A2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM50334929(1-({4-[3-(Trifluoromethyl)-6,7-dihydropyrano[4,3-c...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human CYP2C9 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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