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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267471(N-(pyridin-2-yl)-6-(tributylstannyl)nicotinamide |...)
Affinity DataEC50:  55nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267472(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267473(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267474(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267475(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267476(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267477(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267478(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267479(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50:  55nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267480(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267481(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267482(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50:  550nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267483(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267485(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267487(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50:  55nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267488(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50:  550nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267489(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: >1.00E+3nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267490(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50:  550nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267491(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267492(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267493(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50:  55nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267494(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50:  550nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267495(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50:  55nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267496(4-(8-amino-3-(tetrahydro-2H-pyran-4-yl)imidazo [1,...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267497(4-(8-amino-3-(tetrahydro-2H-pyran-4-yl)imidazo[1,5...)
Affinity DataEC50:  55nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267498(4-(8-amino-3-(tetrahydro-2H-pyran-4-yl)imidazo [1,...)
Affinity DataEC50:  55nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267499(4-(8-amino-3-(tetrahydro-2H-pyran-4-yl)imidazo[1,5...)
Affinity DataEC50:  55nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267500(4-(8-amino-3-(tetrahydro-2H-pyran-4-yl)imidazo[1,5...)
Affinity DataEC50:  550nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267501(4-(8-amino-3-(tetrahydro-2H-pyran-4-yl)imidazo[1,5...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267502(4-(8-amino-3-((1R,5S,6S)-3-oxabicyc1o[3.1.0]hexan-...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267503(4-(8-amino-34(1R,5S,6S)-3-oxabicyclo[3.1.0]hexan-6...)
Affinity DataEC50:  55nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267504(4-(8-amino-3-((1R,5S,6S)-3-oxabicyclo[3.1.0]hexan-...)
Affinity DataEC50:  55nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267505(4-(8-amino-3-(tetrahydrofuran-3-yl)imidazo[1,5-a]p...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267506(4-(8-amino-3-(2,2-dimethyltetrahydro-2H-pyran-4-yl...)
Affinity DataEC50:  55nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267507(4-(8-amino-3-(2,2-dimethyltetrahydro-2H-pyran-4-yl...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267508(4-(8-amino-3-(2,2-dimethyltetrahydro-2H-pyran-4-yl...)
Affinity DataEC50:  55nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267509(4-(8-amino-3-(2,2-dimethyltetrahydro-2H-pyran-4-yl...)
Affinity DataEC50:  55nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267510((trans)-4-(8-amino-1-(4-(5-ethylthiazol-2-ylcarbam...)
Affinity DataEC50:  55nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267511(4-(8-amino-3-((cis)-4-methoxycyclohexyl)imidazo [1...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267512(4-(8-amino-3-((cis)-4-methoxycyclohexyl)imidazo [1...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267513(4-(8-amino-3-((cis)-4-methoxycyclohexyl)imidazo [1...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267514(4-(8-amino-3-((cis)-4-methoxycyclohexyl)imidazo [1...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267515(4-(8-amino-3-cyclopentylimidazo[1,5-a]pyrazin-1-yl...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267516(4-(8-amino-3-cyclopentylimidazo[1,5-a]pyrazin-1-yl...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267517((R)-4-(8-amino-3-(1-propionylpiperidin-3-yl) imida...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267518((R)-ethyl 3-(8-amino-1-(4-(pyridin-2-ylcarbamoyl)p...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267519((R)-3-(8-amino-1-(4-(pyridin-2-ylcarbamoyl)phenyl)...)
Affinity DataEC50:  550nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267520((R)-4-(8-amino-3-(1-(3-methyloxetane-3 carbonyl)pi...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267521((R)-4-(8-amino-3-(1-isobutyrylpiperidin-3 yl)imida...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267522((R)-4-(8-amino-3-(1-(cyclopropanecarbonyl) piperid...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

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