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TargetRetinoic acid receptor alpha [200-419]/gamma [183-417](Human)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

LigandPNGBDBM36811(BMS614)
Affinity DataKi:  1nM ΔG°:  -47.8kJ/molepH: 8.0 T: 4°CAssay Description:Competitive assay were perform with 5nM tritiated all-trans retinoic acid (t-RA; 5nM) with or without 100-fold excess of non-radioactive t-RA (500nM)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRetinoic acid receptor alpha [200-419]/gamma [183-417](Human)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

LigandPNGBDBM36810(BMS753 | US9963439, BMS753)
Affinity DataKi:  1nM ΔG°:  -47.8kJ/molepH: 8.0 T: 4°CAssay Description:Competitive assay were perform with 5nM tritiated all-trans retinoic acid (t-RA; 5nM) with or without 100-fold excess of non-radioactive t-RA (500nM)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRetinoic acid receptor gamma [183-417](Human)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

LigandPNGBDBM31889(BMS 961 | BMS270394 | BMS961)
Affinity DataKi:  1.5nM ΔG°:  -46.8kJ/molepH: 8.0 T: 4°CAssay Description:Competitive assay were perform with 5nM tritiated all-trans retinoic acid (t-RA; 5nM) with or without 100-fold excess of non-radioactive t-RA (500nM)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetRetinoic acid receptor alpha [200-419](Human)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

LigandPNGBDBM36810(BMS753 | US9963439, BMS753)
Affinity DataKi:  2nM ΔG°:  -46.2kJ/molepH: 8.0 T: 4°CAssay Description:Competitive assay were perform with 5nM tritiated all-trans retinoic acid (t-RA; 5nM) with or without 100-fold excess of non-radioactive t-RA (500nM)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRetinoic acid receptor alpha [200-419](Human)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

LigandPNGBDBM36811(BMS614)
Affinity DataKi:  2.5nM ΔG°:  -45.6kJ/molepH: 8.0 T: 4°CAssay Description:Competitive assay were perform with 5nM tritiated all-trans retinoic acid (t-RA; 5nM) with or without 100-fold excess of non-radioactive t-RA (500nM)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB


TargetPlatelet-derived growth factor receptor alpha(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50341234(4-(chloromethyl)-N-(4-methyl-3-(4-(pyridin-3-yl)py...)
Affinity DataIC50:  139nMAssay Description:Inhibition of human wild type PDGFRalpha assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlatelet-derived growth factor receptor alpha(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human wild type PDGFRalpha assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetMast/stem cell growth factor receptor Kit(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50341234(4-(chloromethyl)-N-(4-methyl-3-(4-(pyridin-3-yl)py...)
Affinity DataIC50:  245nMAssay Description:Inhibition of human wild type KIT assessed as [gamma33P]ATP incorporation into polyGluTyr after 60 mins by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMast/stem cell growth factor receptor Kit(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  370nMAssay Description:Inhibition of human wild type KIT assessed as [gamma33P]ATP incorporation into polyGluTyr after 60 mins by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMast/stem cell growth factor receptor Kit(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50341236(4-((2-chloroacetamido)methyl)-N-(4-methyl-3-(4-(py...)
Affinity DataIC50:  788nMAssay Description:Inhibition of human wild type KIT assessed as [gamma33P]ATP incorporation into polyGluTyr after 60 mins by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMast/stem cell growth factor receptor Kit(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50341235(4-(aminomethyl)-N-(4-methyl-3-(4-(pyridin-3-yl)pyr...)
Affinity DataIC50:  788nMAssay Description:Inhibition of human wild type KIT assessed as [gamma33P]ATP incorporation into polyGluTyr after 60 mins by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlatelet-derived growth factor receptor alpha(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50341236(4-((2-chloroacetamido)methyl)-N-(4-methyl-3-(4-(py...)
Affinity DataIC50:  1.08E+3nMAssay Description:Inhibition of human wild type PDGFRalpha assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlatelet-derived growth factor receptor alpha(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50341235(4-(aminomethyl)-N-(4-methyl-3-(4-(pyridin-3-yl)pyr...)
Affinity DataIC50:  1.54E+3nMAssay Description:Inhibition of human wild type PDGFRalpha assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase ABL1(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of human wild type ABL1 assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetMast/stem cell growth factor receptor Kit(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50341238(4-(methacrylamidomethyl)-N-(4-methyl-3-(4-(pyridin...)
Affinity DataIC50:  2.74E+3nMAssay Description:Inhibition of human wild type KIT assessed as [gamma33P]ATP incorporation into polyGluTyr after 60 mins by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlatelet-derived growth factor receptor alpha(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50341238(4-(methacrylamidomethyl)-N-(4-methyl-3-(4-(pyridin...)
Affinity DataIC50:  4.11E+3nMAssay Description:Inhibition of human wild type PDGFRalpha assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMast/stem cell growth factor receptor Kit(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50341237(4-(but-2-enamidomethyl)-N-(4-methyl-3-(4-(pyridin-...)
Affinity DataIC50:  4.71E+3nMAssay Description:Inhibition of human wild type KIT assessed as [gamma33P]ATP incorporation into polyGluTyr after 60 mins by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlatelet-derived growth factor receptor alpha(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50341237(4-(but-2-enamidomethyl)-N-(4-methyl-3-(4-(pyridin-...)
Affinity DataIC50:  4.89E+3nMAssay Description:Inhibition of human wild type PDGFRalpha assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase ABL1(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50341234(4-(chloromethyl)-N-(4-methyl-3-(4-(pyridin-3-yl)py...)
Affinity DataIC50:  6.95E+3nMAssay Description:Inhibition of human wild type ABL1 assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase ABL1(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50341238(4-(methacrylamidomethyl)-N-(4-methyl-3-(4-(pyridin...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human wild type ABL1 assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase ABL1(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50341235(4-(aminomethyl)-N-(4-methyl-3-(4-(pyridin-3-yl)pyr...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human wild type ABL1 assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase ABL1(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50341236(4-((2-chloroacetamido)methyl)-N-(4-methyl-3-(4-(py...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human wild type ABL1 assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase ABL1(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50341237(4-(but-2-enamidomethyl)-N-(4-methyl-3-(4-(pyridin-...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human wild type ABL1 assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVitamin D3 receptor(Human)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

Curated by ChEMBL
LigandPNGBDBM50409927(CHEMBL2112315)
Affinity DataEC50:  0.350nMAssay Description:Effective concentration required for inhibition of Vitamin D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVitamin D3 receptor(Human)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

Curated by ChEMBL
LigandPNGBDBM50409926(CHEMBL2112314)
Affinity DataEC50:  0.400nMAssay Description:Effective concentration required for inhibition of Vitamin D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVitamin D3 receptor(Human)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)

Curated by ChEMBL
LigandPNGBDBM50143770((1R,3S)-5-[2-[(3aS,7aR)-1-((R)-5-Hydroxy-1,5-dimet...)
Affinity DataEC50:  0.180nMAssay Description:Effective concentration required for inhibition of Vitamin D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed