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TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190466(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-{4-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190487(N-(3,5-diamino-6-chloropyrazine-2-carbony)-N'-{4-[...)
Affinity DataIC50: 7nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190462(N-(3,5-diamino-6-chloropyrazine-2-carbony)-N'-{4-[...)
Affinity DataIC50: 8nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190494(N-(3,5-diamino-6-chloropyrazine-2-carbony)-N'-{4-[...)
Affinity DataIC50: 9nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190486(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-{4-...)
Affinity DataIC50: 9nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190481(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-[4-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190459(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-[4-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190484(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-[4-...)
Affinity DataIC50: 17nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190468(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-{4-...)
Affinity DataIC50: 17nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190489((4-{4-[N-(3,5-diamino-6-chloropyrazine-2-carbonyl)...)
Affinity DataIC50: 20nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190475(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-[4-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190465(1-(4-(4-aminophenyl)butyl)-3-(3,5-diamino-2-chloro...)
Affinity DataIC50: 21nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190458(sulfuric acid mono-(4-{4-[N-(3,5-diamino-6-chlorop...)
Affinity DataIC50: 21nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190488(4-{4-[N'-(3,5-diamino-6-chloropyrazine-2-carbonyl)...)
Affinity DataIC50: 22nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190480(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-[3-...)
Affinity DataIC50: 25nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190490(N-(3,5-diamino-6-chloropyrazine-2-carbony)-N'-{4-[...)
Affinity DataIC50: 26nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190493(N-(3,5-diamino-6-chloropyrazine-2-carbony)-N'-{4-[...)
Affinity DataIC50: 28nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190456(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-(4-...)
Affinity DataIC50: 29nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190471(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-[4-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190455(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-{4-...)
Affinity DataIC50: 31nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190478(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-[3-...)
Affinity DataIC50: 32nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190460(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-[2-...)
Affinity DataIC50: 41nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190457(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-[4-...)
Affinity DataIC50: 42nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190483((4-{4-[N-(3,5-diamino-6-chloropyrazine-2-carbonyl)...)
Affinity DataIC50: 48nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190479(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-(3-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190477(4-{4-[N'-(3,5-diamino-6-chloropyrazine-2-carbonyl)...)
Affinity DataIC50: 51nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190461(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-(6-...)
Affinity DataIC50: 58nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190463(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-[2-...)
Affinity DataIC50: 62nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190464(1-(3,5-diamino-2-chloropyrazine-6-carbonyl)-3-(5-(...)
Affinity DataIC50: 64nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190485(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-phe...)
Affinity DataIC50: 66nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM81819(NSC_108107 | CHEMBL212579 | CAS_1937-37-7 | Benzam...)
Affinity DataIC50: 66nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190470(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-(5-...)
Affinity DataIC50: 68nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190474(6-(4-{4-[N'-(3,5-diamino-6-chloropyrazine-2-carbon...)
Affinity DataIC50: 73nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190495(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-[5-...)
Affinity DataIC50: 77nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190491(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-hex...)
Affinity DataIC50: 87nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190472(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-[3-...)
Affinity DataIC50: 88nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190473(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-(2-...)
Affinity DataIC50: 107nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190492(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-oct...)
Affinity DataIC50: 108nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190482(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-[3-...)
Affinity DataIC50: 124nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM115076(cid_9604979 | 3,5-diamino-N-[amino(anilino)methyli...)
Affinity DataIC50: 401nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM50190469(N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-(8-...)
Affinity DataIC50: 477nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmiloride-sensitive sodium channel subunit alpha(Human)
Parion Sciences

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataIC50: 776nMAssay Description:Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM24198([(2R)-3-amino-2-fluoropropyl](methyl)phosphinic ac...)
Affinity DataKi:  4.30nM ΔG°:  -47.3kJ/mole EC50:  14nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
LigandPNGBDBM24195(AZD3355 | [(2R)-3-amino-2-fluoropropyl]phosphinic ...)
Affinity DataKi:  5.10nM ΔG°:  -46.9kJ/mole EC50:  8.64nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
LigandPNGBDBM24193((3-amino-2-fluoropropyl)phosphinic acid | 3-aminop...)
Affinity DataKi:  10nM ΔG°:  -45.2kJ/mole EC50:  15nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
LigandPNGBDBM24196((3-amino-2-fluoropropyl)(methyl)phosphinic acid | ...)
Affinity DataKi:  14nM ΔG°:  -44.4kJ/mole EC50:  23nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
LigandPNGBDBM24184((3-aminopropyl)phosphinic acid | CHEMBL112203 | CG...)
Affinity DataKi:  15nM ΔG°:  -44.2kJ/mole EC50:  19nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
LigandPNGBDBM24185(CGP35024 | 3-Apmpa | CHEMBL112710 | (3-aminopropyl...)
Affinity DataKi:  33nM ΔG°:  -42.3kJ/mole EC50:  41nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM24191((3-amino-2-oxopropyl)phosphinic acid | (3-amino-2-...)
Affinity DataKi:  48nM ΔG°:  -41.4kJ/mole EC50:  81nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
LigandPNGBDBM24186(3-aminopropylphosphinic derivative, (S)-3 | CHEMBL...)
Affinity DataKi:  50nM ΔG°:  -41.3kJ/mole EC50:  130nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2008
Entry Details Article
PubMed
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