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TargetBile acid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50562162(CHEMBL4753047)
Affinity DataEC50:  8.30E+3nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells co-transfected with BSEP plasmid assessed as receptor transactivation after 24 hrs by BSEP-l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50562163(CHEMBL4741685)
Affinity DataEC50:  3.20E+3nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells co-transfected with BSEP plasmid assessed as receptor transactivation after 24 hrs by BSEP-l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50562164(CHEMBL4747132)
Affinity DataEC50:  740nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells co-transfected with BSEP plasmid assessed as receptor transactivation after 24 hrs by BSEP-l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50562165(CHEMBL4746964)
Affinity DataEC50:  7.60E+3nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells co-transfected with BSEP plasmid assessed as receptor transactivation after 24 hrs by BSEP-l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50562166(CHEMBL4758738)
Affinity DataEC50:  5.20E+3nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells co-transfected with BSEP plasmid assessed as receptor transactivation after 24 hrs by BSEP-l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50562167(CHEMBL4762018)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells co-transfected with BSEP plasmid assessed as receptor transactivation after 24 hrs by BSEP-l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50562168(CHEMBL4755001)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells co-transfected with BSEP plasmid assessed as receptor transactivation after 24 hrs by BSEP-l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50562169(CHEMBL4761277)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells co-transfected with BSEP plasmid assessed as receptor transactivation after 24 hrs by BSEP-l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50562170(CHEMBL4785785)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells co-transfected with BSEP plasmid assessed as receptor transactivation after 24 hrs by BSEP-l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50562171(CHEMBL4760112)
Affinity DataEC50:  370nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells co-transfected with BSEP plasmid assessed as receptor transactivation after 24 hrs by BSEP-l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50562172(CHEMBL4746765)
Affinity DataEC50:  410nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells co-transfected with BSEP plasmid assessed as receptor transactivation after 24 hrs by BSEP-l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM21724(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(p...)
Affinity DataEC50:  260nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells co-transfected with BSEP plasmid assessed as receptor transactivation after 24 hrs by BSEP-l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50527040(LJN-452 | LJN452 | NVP-LJN452-NXA | Tropifexor)
Affinity DataEC50:  180nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells co-transfected with BSEP plasmid assessed as receptor transactivation after 24 hrs by BSEP-l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50507495(CHEMBL4445464)
Affinity DataEC50:  0.720nMAssay Description:Inhibition of human PD-1/PD-L1 interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50507495(CHEMBL4445464)
Affinity DataEC50:  0.410nMAssay Description:Inhibition of human PD-1 expressed in rat PBMCs/human PD-L1 expressed in MDA-MB-231 cells protein-protein interaction assessed as increase in PBMCs p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetProgrammed cell death 1 ligand 1(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50608311(CHEMBL5287840)
Affinity DataEC50:  30nMAssay Description:Inhibition of PD-L1 in mouse splenocytes assessed as increase in INFgamma releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetProgrammed cell death 1 ligand 1(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50608312(CHEMBL5271329)
Affinity DataEC50:  27nMAssay Description:Inhibition of PD-L1 in mouse splenocytes assessed as increase in INFgamma releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetProgrammed cell death 1 ligand 1(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50608313(CHEMBL5289147)
Affinity DataEC50:  40nMAssay Description:Inhibition of PD-L1 in mouse splenocytes assessed as increase in INFgamma releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetProgrammed cell death 1 ligand 1(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50587706(CHEMBL5197008)
Affinity DataEC50:  34nMAssay Description:Inhibition of PD-L1 in mouse splenocytes assessed as increase in INFgamma releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetProgrammed cell death 1 ligand 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50587706(CHEMBL5197008)
Affinity DataEC50:  56nMAssay Description:Inhibition of PD-L1 in human PBMCs assessed as increase in INFgamma productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetProgrammed cell death 1 ligand 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50587706(CHEMBL5197008)
Affinity DataEC50:  149nMAssay Description:Inhibition of PD-L2 in human PBMCs assessed as increase in INFgamma productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetProgrammed cell death 1 ligand 2(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50587706(CHEMBL5197008)
Affinity DataEC50:  55nMAssay Description:Inhibition of PD-L2 in mouse splenocytes assessed as increase in INFgamma productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAndrogen receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50435990(VN/124 | VN/124-1 | TOK-001 | GALETERONE | US96112...)
Affinity DataEC50:  1.04E+4nMAssay Description:Induction of degradation of full length Androgen receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetAndrogen receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50609682(CHEMBL5184863)
Affinity DataEC50:  1.00E+3nMAssay Description:Induction of degradation of AR LBD in human LNCaP cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetAndrogen receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50609683(CHEMBL5279873)
Affinity DataEC50:  2.00E+3nMAssay Description:Induction of degradation of AR LBD in human LNCaP cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50633718(CHEMBL5180854)
Affinity DataKd:  27nMAssay Description:Binding affinity to Amyloid beta (1 to 42) aggregates (unknown origin) assessed as fluorescent intensities measured after 30 mins by fluorescence spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50633719(CHEMBL5438212)
Affinity DataKd:  78nMAssay Description:Binding affinity to Amyloid beta (1 to 42) aggregates (unknown origin) assessed as fluorescent intensities measured after 30 mins by fluorescence spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50633720(CHEMBL5197690)
Affinity DataKd:  55nMAssay Description:Binding affinity to Amyloid beta (1 to 42) aggregates (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetUbiquitin thioesterase OTUB1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50591324(CHEMBL5185273)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of N-terminal His-6 tagged OTUB1 (40 to 271 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Ub-Rho measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 8(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50591324(CHEMBL5185273)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of N-terminal His-6 tagged USP8 (734 to 1110 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells measured after 3 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetUbiquitin thioesterase OTUB1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50591323(CHEMBL5173239)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of N-terminal His-6 tagged OTUB1 (40 to 271 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Ub-Rho measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2016
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50341250(N-{(3R,5R)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)-...)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of BTK (unknown origin) by ADP-gloassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50341249(1,1-Dimethylethyl{(3R,5R)-1-[2-Amino-6-(3-amino-1H...)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 0.890nMAssay Description:Inhibition of BTK (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant full length human N-terminal His tagged BTK expressed in baculovirus infected Sf9 cells using poly (4:1 Glu, Tyr) as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316497(N-{4-[1-(2,3-Dihydroxypropyl)-4-(1H-pyrrolo[2,3-b]...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataIC50: 1nMAssay Description:Competitive inhibition of Aurora B ATP binding siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of BLK (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 8(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50591322(CHEMBL5196686)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of N-terminal His-6 tagged USP8 (734 to 1110 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells measured after 3 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50239948(US9850225, Example 1166 | CHEMBL4071326)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human PD-1/PD-L1 interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316473(4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyr...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316475(N-Ethyl-N'-[4-(1-ethyl-4-{2-[4-(1-pyrrolidinylmeth...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50341241((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetUbiquitin thioesterase OTUB1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50591321(CHEMBL5172138)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of N-terminal His-6 tagged OTUB1 (40 to 271 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Ub-Rho measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316471(4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyr...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of PARP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetUbiquitin carboxyl-terminal hydrolase 8(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50591323(CHEMBL5173239)
Affinity DataIC50: 2nMAssay Description:Inhibition of N-terminal His-6 tagged USP8 (734 to 1110 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells measured after 3 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
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