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LigandPNGBDBM8465(CGS 27023 | CHEMBL514138 | hydroxamate analogue 1 ...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2008
Entry Details Article
PubMed
LigandPNGBDBM13139((2S)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2008
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173235((S)-2-{4'-[(5-Bromo-4-methoxy-benzofuran-2-carbony...)
Affinity DataIC50: 0.400nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394655(US10308615, Example 12 | preparation of {2-[(pyrid...)
Affinity DataIC50: 0.5nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
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TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173236((S)-2-{4'-[(5-Bromo-benzofuran-2-carbonyl)-amino]-...)
Affinity DataIC50: 0.610nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394660(US10308615, Example 17 | preparation of [3-(methyl...)
Affinity DataIC50: 0.800nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
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Target72 kDa type IV collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173236((S)-2-{4'-[(5-Bromo-benzofuran-2-carbonyl)-amino]-...)
Affinity DataIC50: 0.910nMAssay Description:Inhibitory concentration against MMP-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259007(N-({4'-[(4-isobutyrylphenoxy)methyl]biphenyl-4-yl}...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM395062(US10308615, Example 73 | (2-{[(6- methylpyridin-3-...)
Affinity DataIC50: 1.20nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
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Target72 kDa type IV collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259007(N-({4'-[(4-isobutyrylphenoxy)methyl]biphenyl-4-yl}...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394659(US10308615, Example 16 | preparation of (2-{[1-(py...)
Affinity DataIC50: 1.70nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
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TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM395062(US10308615, Example 73 | (2-{[(6- methylpyridin-3-...)
Affinity DataIC50: 1.70nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394660(US10308615, Example 17 | preparation of [3-(methyl...)
Affinity DataIC50: 1.80nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394655(US10308615, Example 12 | preparation of {2-[(pyrid...)
Affinity DataIC50: 1.90nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
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TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173220((S)-2-{4'-[(5-Chloro-4-methoxy-3-methyl-benzofuran...)
Affinity DataIC50: 1.90nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394656(US10308615, Example 13 | [3-(methylsulfonyl)phenyl...)
Affinity DataIC50: 2nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394645(US10308615, Example 2 | 3-[(2-{[1-(pyridin-3-yl)cy...)
Affinity DataIC50: 2.10nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173218((S)-2-{4'-[(5-Iodo-4-methoxy-3-methyl-benzofuran-2...)
Affinity DataIC50: 2.10nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259009((R)-3-methyl-2-(4'-((5-oxo-5,6,7,8-tetrahydronapht...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173223((S)-2-{4'-[(5-Bromo-4-methoxy-3-methyl-benzofuran-...)
Affinity DataIC50: 2.30nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50170298((S)-2-{4'-[(4-Methoxy-benzofuran-2-carbonyl)-amino...)
Affinity DataIC50: 2.30nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28485((2S)-2-({4-[4-(1-benzofuran-2-amido)phenyl]benzene...)
Affinity DataIC50: 2.40nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394659(US10308615, Example 16 | preparation of (2-{[1-(py...)
Affinity DataIC50: 2.60nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM24043((2R)-2-({4-[4-(1-benzofuran-2-amido)phenyl]benzene...)
Affinity DataIC50: 2.60nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394655(US10308615, Example 12 | preparation of {2-[(pyrid...)
Affinity DataIC50: 2.90nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173229((S)-2-{4'-[(5-Cyano-4-methoxy-3-methyl-benzofuran-...)
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173224((S)-2-{4'-[(5-Bromo-3-methyl-benzofuran-2-carbonyl...)
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173237((S)-2-{4'-[(5-Acetyl-4-hydroxy-3-methyl-benzofuran...)
Affinity DataIC50: 3.20nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394648(US10308615, Example 5 | 3-[(2-{[1-(pyrazin-2-yl)cy...)
Affinity DataIC50: 3.40nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM395070(US10308615, Example 81 | [4-fluoro-3- (trifluorome...)
Affinity DataIC50: 3.40nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173221((R)-2-{4'-[(5-Bromo-4-methoxy-3-methyl-benzofuran-...)
Affinity DataIC50: 3.40nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Hangzhou Polymed Biopharmaceuticals

US Patent
LigandPNGBDBM708330(US20240423977, Example II-7)
Affinity DataIC50: 3.57nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/7/2025
Entry Details
Go to US Patent

Target72 kDa type IV collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258875((R)-2-(4'-((4-(4-fluorobenzoyl)phenoxy)methyl)biph...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173228((S)-2-{4'-[(5-Ethyl-4-methoxy-3-methyl-benzofuran-...)
Affinity DataIC50: 3.80nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394650(US10308615, Example 7 | 3-[(2-{[1-(pyridin-3-yl)et...)
Affinity DataIC50: 3.90nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM395107(US10308615, Example 118 | 3-({2-[(pyridin-3- ylmet...)
Affinity DataIC50: 4nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394644(US10308615, Example 1 | 3-[(2-{[1-(pyrimidin-5-yl)...)
Affinity DataIC50: 4.10nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM24047((2R)-3-methyl-2-[(4-{4-[(3-methyl-1-benzofuran-2-y...)
Affinity DataIC50: 4.40nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2008
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM395107(US10308615, Example 118 | 3-({2-[(pyridin-3- ylmet...)
Affinity DataIC50: 4.60nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

Target72 kDa type IV collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM24043((2R)-2-({4-[4-(1-benzofuran-2-amido)phenyl]benzene...)
Affinity DataIC50: 4.60nMAssay Description:Inhibitory concentration against MMP-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Hangzhou Polymed Biopharmaceuticals

US Patent
LigandPNGBDBM708319(US20240423977, Example I-13)
Affinity DataIC50: 4.81nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/7/2025
Entry Details
Go to US Patent

TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173222((S)-2-{4'-[(4-methoxy-3,5-dimethyl-benzofuran-2-ca...)
Affinity DataIC50: 4.90nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28485((2S)-2-({4-[4-(1-benzofuran-2-amido)phenyl]benzene...)
Affinity DataIC50: 5nMAssay Description:Inhibitory concentration against MMP-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258917((R)-2-(4'-((4-(cyclohexanecarbonyl)phenoxy)methyl)...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Hangzhou Polymed Biopharmaceuticals

US Patent
LigandPNGBDBM708369(US20240423977, Example I-51)
Affinity DataIC50: 5.33nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/7/2025
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Hangzhou Polymed Biopharmaceuticals

US Patent
LigandPNGBDBM708331(US20240423977, Example II-20)
Affinity DataIC50: 5.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/7/2025
Entry Details
Go to US Patent

TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173226((S)-3-Methyl-2-{4'-[(3-methyl-benzofuran-2-carbony...)
Affinity DataIC50: 5.90nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM395108(US10308615, Example 119 | {2-[(pyrimidin-5- ylmeth...)
Affinity DataIC50: 6.10nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394654(US10308615, Example 11 | {2-[(pyrazin-2-ylmethyl)a...)
Affinity DataIC50: 6.20nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

Target72 kDa type IV collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259009((R)-3-methyl-2-(4'-((5-oxo-5,6,7,8-tetrahydronapht...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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