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TargetVasopressin V2 receptor(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50146577(CHEMBL102311 | spirobenzoxazines analogues)
Affinity DataIC50:  0.200nMAssay Description:In vitro inhibitory concentration against [3H]-AVP binding to cloned human vasopressin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225162((4R)-N-[2-(dimethylamino)ethyl]-1-({4-[(2-phenylbe...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50366915(CHEMBL1788220)
Affinity DataIC50:  2nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147227(3'N-(3-dimethylaminopropyl)-1-[4-(5-fluoro-2-methy...)
Affinity DataIC50:  4nMAssay Description:Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147220(4-{2-[1-[4-(2-fluorophenylcarboxamido)benzoyl]spir...)
Affinity DataIC50:  4nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50366914(CHEMBL1788221)
Affinity DataIC50:  4nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147223(3'N-(2-hydroxyethyl)-1-[4-(2-fluorophenylcarboxami...)
Affinity DataIC50:  4nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147224(3'N-(2-dimethylaminoethyl)-1-[4-(2-phenylphenylcar...)
Affinity DataIC50:  4nMAssay Description:Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147228(3'N-(3-dimethylaminopropyl)-1-[4-(2-phenylphenylca...)
Affinity DataIC50:  5nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147227(3'N-(3-dimethylaminopropyl)-1-[4-(5-fluoro-2-methy...)
Affinity DataIC50:  5nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rat)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50366915(CHEMBL1788220)
Affinity DataIC50:  5nMAssay Description:Evaluated for binding affinity towards vasopressin V2 receptor in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147224(3'N-(2-dimethylaminoethyl)-1-[4-(2-phenylphenylcar...)
Affinity DataIC50:  5nMAssay Description:Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147219(3'N-(2-dimethylaminoethyl)-1-[4-(5-fluoro-2-methyl...)
Affinity DataIC50:  5nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  5nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225163((4R)-1-({4-[(2-chloro-5-fluorobenzene)amido]-3-met...)
Affinity DataIC50:  5nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147221(3'N-(2-hydroxyethyl)-1-[4-(2-phenylphenylcarboxami...)
Affinity DataIC50:  5nMAssay Description:Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147221(3'N-(2-hydroxyethyl)-1-[4-(2-phenylphenylcarboxami...)
Affinity DataIC50:  6nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147230(CHEMBL319636 | methyl 2-[1-[4-(5-fluoro-2-methylph...)
Affinity DataIC50:  7nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147225(3'N-(2-hexahydro-1-pyridinylethyl)-1-[4-(2-fluorop...)
Affinity DataIC50:  7nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225166((4R)-1-({4-[(2-chloro-5-fluorobenzene)amido]-3-eth...)
Affinity DataIC50:  8nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50366915(CHEMBL1788220)
Affinity DataIC50:  8nMAssay Description:Evaluated for intracellular calcium mobilization in HEK- 293 cells transfected to express human vasopressin V1a receptor (Compound 7o)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50147229(3'N-(2-hexahydro-1-pyridinylethyl)-1-[4-(5-fluoro-...)
Affinity DataIC50:  8nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human V2 receptor (Compound 7o)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147226(3'N-(2-tetrahydro-1H-1-pyrrolylethyl)-1-[4-(2-fluo...)
Affinity DataIC50:  8nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50225162((4R)-N-[2-(dimethylamino)ethyl]-1-({4-[(2-phenylbe...)
Affinity DataIC50:  8nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50146578(CHEMBL103406 | spirobenzoxazines analogues)
Affinity DataIC50:  8nMAssay Description:In vitro inhibitory concentration against [3H]-AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147222(3'N-(2-dimethylaminoethyl)-1-[4-(2-fluorophenylcar...)
Affinity DataIC50:  8nMAssay Description:Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225167(CHEMBL250346 | N-(4-{[3'-(hydroxymethyl)-1,2,3,5-t...)
Affinity DataIC50:  9nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225167(CHEMBL250346 | N-(4-{[3'-(hydroxymethyl)-1,2,3,5-t...)
Affinity DataIC50:  9nMAssay Description:Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracllular calciu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50147229(3'N-(2-hexahydro-1-pyridinylethyl)-1-[4-(5-fluoro-...)
Affinity DataIC50:  9nMAssay Description:Evaluated for accumulation of cAMP in transfected HEK293 cells expressing human V2 receptor (Compound 7o)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50146566(CHEMBL440147 | spirobenzoxazines analogues)
Affinity DataIC50:  10nMAssay Description:In vitro inhibitory concentration against [3H]-AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50146565(CHEMBL101157 | spirobenzoxazines analogues)
Affinity DataIC50:  10nMAssay Description:In vitro inhibitory concentration against [3H]-AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50146572(CHEMBL100402 | spirobenzoxazines analogues)
Affinity DataIC50:  10nMAssay Description:In vitro inhibitory concentration against [3H]-AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147229(3'N-(2-hexahydro-1-pyridinylethyl)-1-[4-(5-fluoro-...)
Affinity DataIC50:  10nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50147230(CHEMBL319636 | methyl 2-[1-[4-(5-fluoro-2-methylph...)
Affinity DataIC50:  10nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50225159((4R)-1-({4-[(2-chloro-5-fluorobenzene)amido]-3-met...)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at human vasopressin V2 receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced cAMP levelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50147224(3'N-(2-dimethylaminoethyl)-1-[4-(2-phenylphenylcar...)
Affinity DataIC50:  11nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50147221(3'N-(2-hydroxyethyl)-1-[4-(2-phenylphenylcarboxami...)
Affinity DataIC50:  11nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50146562(CHEMBL100893 | spirobenzoxazines analogues)
Affinity DataIC50:  12nMAssay Description:In vitro inhibitory concentration against [3H]-AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225173((4R)-1-({4-[(2-chloro-5-fluorobenzene)amido]phenyl...)
Affinity DataIC50:  13nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50225168(1-({4-[(2-phenylbenzene)amido]phenyl}carbonyl)-1,2...)
Affinity DataIC50:  14nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225172(CHEMBL251771 | methyl 1-({4-[(2-fluorobenzene)amid...)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50146571(CHEMBL101187 | spirobenzoxazines analogues)
Affinity DataIC50:  15nMAssay Description:In vitro inhibitory concentration against [3H]-AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50146576(CHEMBL316958 | spirobenzoxazines analogues)
Affinity DataIC50:  16nMAssay Description:In vitro inhibitory concentration against [3H]-AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147229(3'N-(2-hexahydro-1-pyridinylethyl)-1-[4-(5-fluoro-...)
Affinity DataIC50:  16nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptor (Compound 7o)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50147228(3'N-(3-dimethylaminopropyl)-1-[4-(2-phenylphenylca...)
Affinity DataIC50:  16nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50147231(2-[1-[4-(2-phenylphenylcarboxamido)benzoyl]spiro[2...)
Affinity DataIC50:  18nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225170(CHEMBL400267 | N-[4-({3'-[(methylamino)methyl]-1,2...)
Affinity DataIC50:  18nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50225167(CHEMBL250346 | N-(4-{[3'-(hydroxymethyl)-1,2,3,5-t...)
Affinity DataIC50:  18nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225160(1-({4-[(2-chloro-5-fluorobenzene)amido]-3-methoxyp...)
Affinity DataIC50:  19nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147232(3'N-(2-tetrahydro-1H-1-pyrrolylethyl)-1-[4-(5-fluo...)
Affinity DataIC50:  19nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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