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TargetTyrosine-protein kinase JAK2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of JAK2 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetTyrosine-protein kinase JAK1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of JAK1 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetMu-type opioid receptor(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50463297(CHEMBL4246433)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]DAMGO from human MOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50463294(CHEMBL4249256)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]U69,593 from human KOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50506108(CHEMBL4449252)
Affinity DataKi:  0.470nMAssay Description:Displacement of [3H]U69593 from human KOR expressed in CHO cell membranes incubated for 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of TYK2 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362726(CHEMBL1939796)
Affinity DataKi:  0.5nMAssay Description:Inhibition of recombinant human PDE10A using [3H]cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362722(CHEMBL1939800)
Affinity DataKi:  0.600nMAssay Description:Inhibition of recombinant human PDE10A using [3H]cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50463297(CHEMBL4246433)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]U69,593 from human KOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362037(CHEMBL1939916)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]cAMP from human recombinant PDE10A1 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAcetylcholine-binding protein(Great pond snail)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50520722(CHEMBL4554047)
Affinity DataKi:  0.860nMAssay Description:Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50393757(CHEMBL2159143)
Affinity DataKi:  0.900nMAssay Description:Inhibition of JAK1 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362728(CHEMBL1939794)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human PDE10A using [3H]cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362035(CHEMBL1939914)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]cAMP from human recombinant PDE10A1 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362047(CHEMBL1940057)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]cAMP from human recombinant PDE10A1 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50393753(CHEMBL2159202)
Affinity DataKi:  1.20nMAssay Description:Inhibition of JAK1 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50393739(CHEMBL2159142)
Affinity DataKi:  1.30nMAssay Description:Inhibition of JAK1 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50393756(CHEMBL2159198)
Affinity DataKi:  1.30nMAssay Description:Inhibition of JAK1 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50380636(CHEMBL2017060)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50393750(CHEMBL2159205)
Affinity DataKi:  1.5nMAssay Description:Inhibition of JAK1 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50393744(CHEMBL2159210)
Affinity DataKi:  1.80nMAssay Description:Inhibition of JAK1 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362046(CHEMBL1940056)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]cAMP from human recombinant PDE10A1 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50393751(CHEMBL2159204)
Affinity DataKi:  2nMAssay Description:Inhibition of JAK1 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50463293(CHEMBL4242847)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]U69,593 from human KOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50393757(CHEMBL2159143)
Affinity DataKi:  2.10nMAssay Description:Inhibition of JAK2 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAcetylcholine-binding protein(Great pond snail)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50520723(CHEMBL4440256)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetProstaglandin D2 receptor 2(Human)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50458670(CHEMBL4212838)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetProstaglandin D2 receptor 2(Human)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50458673(CHEMBL4207731)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50393747(CHEMBL2159208)
Affinity DataKi:  2.60nMAssay Description:Inhibition of JAK1 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50463284(CHEMBL4245818)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]U69,593 from human KOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50393754(CHEMBL2159200)
Affinity DataKi:  2.80nMAssay Description:Inhibition of JAK1 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50393739(CHEMBL2159142)
Affinity DataKi:  2.90nMAssay Description:Inhibition of JAK2 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362725(CHEMBL1939797)
Affinity DataKi:  3nMAssay Description:Inhibition of recombinant human PDE10A using [3H]cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362033(CHEMBL1939912)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]cAMP from human recombinant PDE10A1 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362036(CHEMBL1939915)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]cAMP from human recombinant PDE10A1 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin D2 receptor 2(Human)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50458667(CHEMBL4207935)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetProstaglandin D2 receptor 2(Human)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50458666(CHEMBL4204359)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362711(CHEMBL1939812)
Affinity DataKi:  3.10nMAssay Description:Inhibition of recombinant human PDE10A using [3H]cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK3(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataKi:  3.20nMAssay Description:Inhibition of JAK3 kinase domain using N-terminal 5-carboxyfluorescein-tagged Leu-Pro-Leu-Asp-Lys-Asp-Tyr-Tyr-Val-Val-Arg as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362730(CHEMBL1939792)
Affinity DataKi:  3.30nMAssay Description:Inhibition of recombinant human PDE10A using [3H]cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAcetylcholine-binding protein(Great pond snail)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50520715(CHEMBL4437999)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetProstaglandin D2 receptor 2(Human)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50458672(CHEMBL4203572)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetAcetylcholine-binding protein(Great pond snail)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50520705(CHEMBL4458658)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetProstaglandin D2 receptor 2(Human)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50458652(CHEMBL4202859)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50362733(CHEMBL1939789)
Affinity DataKi:  3.60nMAssay Description:Inhibition of recombinant human PDE10A using [3H]cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50380643(CHEMBL2017067)
Affinity DataKi:  3.80nMAssay Description:Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin D2 receptor 2(Human)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50458681(CHEMBL4215576)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetProstaglandin D2 receptor 2(Human)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50458677(CHEMBL4212084)
Affinity DataKi:  4.10nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 expressed in HEK cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50463292(CHEMBL4243649)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]DAMGO from human MOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50380637(CHEMBL2017061)
Affinity DataKi:  4.30nMAssay Description:Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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