Compile Data Set for Download or QSAR
Report error Found 4294 with Last Name = 'yang' and Initial = 'q'
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067687(5-[1-(4-Bromo-phenyl)-meth-(Z)-ylidene]-2,2,4-trim...)
Affinity DataEC50:  32nMAssay Description:Effective concentration (EC50) against human progesterone receptor expressed in CV-1 cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067679(5-Benzyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataEC50:  16.8nMAssay Description:Effective concentration (EC50) against human progesterone receptor expressed in CV-1 cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Jiangsu Normal University

Curated by ChEMBL
LigandPNGBDBM50554573(CHEMBL4745070)
Affinity DataEC50:  0.180nMAssay Description:Agonist activity at human GLP-1R expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 20 mins in presence of 0% HSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50572743(CHEMBL4866444)
Affinity DataEC50:  5.25E+3nMAssay Description:Partial agonist activity at GAL4 DBD-fused PPARgamma LBD (unknown origin) expressed in pG5 luc and pBIND transfected HEK293T cells assessed as transc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50430575(CHEMBL2337794)
Affinity DataKd:  7.94E+3nMAssay Description:Binding affinity to GAL4-DBD-fused PPARgamma ligand binding domain (unknown origin) expressed in HEK293T cells by spectra-fluorophotometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50572732(CHEMBL4870772)
Affinity DataKd:  6.67E+3nMAssay Description:Binding affinity to GAL4-DBD-fused PPARgamma ligand binding domain (unknown origin) expressed in HEK293T cells by spectra-fluorophotometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Jiangsu Normal University

Curated by ChEMBL
LigandPNGBDBM50151296(CHEMBL3769427)
Affinity DataEC50:  5.30nMAssay Description:Activation of human GLP1R expressed in HEK293 cells preincubated for 30 mins followed by addition of cAMP-d2 conjugate/cryptate conjugate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
LigandPNGBDBM420298(WO2005113580-Ex-02 | PF-00835231 | PF-0835231 | cm...)
Affinity DataEC50:  231nMAssay Description:VeroE6 cells were sorted for ACE2 expression by flow cytometry to generate clonal VeroE6 cells that are enriched for ACE2 surface expression. The ACE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2021
Entry Details

TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

WIPO
LigandPNGBDBM510056(WO2021250648, Example 8 | N-{1-Cyano-2-[(3S)-2-oxo...)
Affinity DataEC50:  5.75E+3nMAssay Description:The ability of compounds to prevent SARS-CoV-2 coronavirus-induced cell death or cytopathic effect can be assessed via cell viability, using an assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2022
Entry Details
WIPO WO2021250648

TargetGlucagon-like peptide 1 receptor(Human)
Jiangsu Normal University

Curated by ChEMBL
LigandPNGBDBM50554510(CHEMBL4747794)
Affinity DataEC50:  0.730nMAssay Description:Agonist activity at human GLP-1R expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Jiangsu Normal University

Curated by ChEMBL
LigandPNGBDBM50554580(CHEMBL4752331)
Affinity DataEC50:  0.0400nMAssay Description:Agonist activity at human GLP-1R expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 20 mins in presence of 0% HSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Jiangsu Normal University

Curated by ChEMBL
LigandPNGBDBM50600022(CHEMBL5181266)
Affinity DataEC50:  0.150nMAssay Description:Agonist activity at human GLP-1R expressed in HEK293 cells assessed as cAMP release incubated for 20 min by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
LigandPNGBDBM50627989(CHEMBL5396638)
Affinity DataEC50:  2.80E+3nMAssay Description:Agonist activity at PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

WIPO
LigandPNGBDBM510122(WO2021250648, Example 74 | US11351149, Example 74)
Affinity DataEC50: >3.33E+3nMAssay Description:The ability of compounds to prevent SARS-CoV-2 coronavirus-induced cell death or cytopathic effect can be assessed via cell viability, using an assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2022
Entry Details
WIPO WO2021250648

TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

WIPO
LigandPNGBDBM510139(WO2021250648, Example 91 | (1R,2S,5S)-N-{(1S)-1-Cy...)
Affinity DataEC50:  11nMAssay Description:The ability of compounds to prevent SARS-CoV-2 coronavirus-induced cell death or cytopathic effect can be assessed via cell viability, using an assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2022
Entry Details
WIPO WO2021250648

TargetMuscarinic acetylcholine receptor M2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM280408(ethyl 4-[4-(3- methoxypyridin- 2-yl)piperidin-1- y...)
Affinity DataEC50:  2.52E+3nMAssay Description:Agonist activity at human Muscarinic acetylcholine receptor M2 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isopr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Jiangsu Normal University

Curated by ChEMBL
LigandPNGBDBM50554560(CHEMBL4757600)
Affinity DataEC50:  0.0930nMAssay Description:Agonist activity at human GLP-1R expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 20 mins in presence of 0% HSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Jiangsu Normal University

Curated by ChEMBL
LigandPNGBDBM50606511(CHEMBL5219263)
Affinity DataEC50:  0.140nMAssay Description:Agonist activity at human GLP-1R expressed in HEK293 cells incubated for 30 mins and assessed as increase in cAMP accumulation measured by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetGlucagon receptor(Human)
Affiliated Tumor Hospital of Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50606517(CHEMBL5221090)
Affinity DataEC50:  0.420nMAssay Description:Agonist activity at human GCGR expressed in HEK293 cells incubated for 30 mins and assessed as increase in cAMP accumulation measured by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Air Force Medical University

Curated by ChEMBL
LigandPNGBDBM50633653(CHEMBL5428266)
Affinity DataKd:  4.37E+3nMAssay Description:Binding affinity to paraoxon-inhibited human erythrocyte AChE assessed as dissociation constant preincubated with paraoxon for 15 mins followed by co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Jiangsu Normal University

Curated by ChEMBL
LigandPNGBDBM50554523(CHEMBL4748303)
Affinity DataEC50:  0.280nMAssay Description:Agonist activity at human GLP-1R expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Jiangsu Normal University

Curated by ChEMBL
LigandPNGBDBM50554557(CHEMBL4754330)
Affinity DataEC50:  2.20nMAssay Description:Agonist activity at human GLP-1R expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 20 mins in presence of 4.4% HSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Jiangsu Normal University

Curated by ChEMBL
LigandPNGBDBM50554553(CHEMBL4756140)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Jiangsu Normal University

Curated by ChEMBL
LigandPNGBDBM50554524(CHEMBL4783339)
Affinity DataEC50:  0.0890nMAssay Description:Agonist activity at human GLP-1R expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetBeclin-1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50586568(CHEMBL5091207)
Affinity DataKd:  100nMAssay Description:Binding affinity to Beclin 1 coiled coil domain (unknown origin) by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
LigandPNGBDBM212883(US9278960, 2-30 | US9663506, Example 2-30)
Affinity DataEC50:  9.70E+3nMAssay Description:Agonist activity at PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCannabinoid receptor 2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50428174(CHEMBL2336549)
Affinity DataEC50:  73nMAssay Description:Inverse agonist activity at human CB2 receptor expressed in CHO cell membranes assessed as inhibition of forskolin-stimulated cAMP production after 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

WIPO
LigandPNGBDBM510083(WO2021250648, Example 35 | US11351149, Example 35)
Affinity DataEC50:  3.56E+3nMAssay Description:The ability of compounds to prevent SARS-CoV-2 coronavirus-induced cell death or cytopathic effect can be assessed via cell viability, using an assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2022
Entry Details
WIPO WO2021250648

TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

WIPO
LigandPNGBDBM510098(WO2021250648, Example 50)
Affinity DataEC50:  3.95E+3nMAssay Description:The ability of compounds to prevent SARS-CoV-2 coronavirus-induced cell death or cytopathic effect can be assessed via cell viability, using an assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2022
Entry Details
WIPO WO2021250648

TargetGlucagon-like peptide 1 receptor(Human)
Jiangsu Normal University

Curated by ChEMBL
LigandPNGBDBM50554533(CHEMBL4740642)
Affinity DataEC50:  0.160nMAssay Description:Agonist activity at human GLP-1R expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Jiangsu Normal University

Curated by ChEMBL
LigandPNGBDBM50554559(CHEMBL4757461)
Affinity DataEC50:  0.0540nMAssay Description:Agonist activity at human GLP-1R expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 20 mins in presence of 0% HSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50572740(CHEMBL4863504)
Affinity DataEC50:  6.29E+3nMAssay Description:Partial agonist activity at GAL4 DBD-fused PPARgamma LBD (unknown origin) expressed in pG5 luc and pBIND transfected HEK293T cells assessed as transc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50572745(CHEMBL4847288)
Affinity DataEC50: >5.00E+4nMAssay Description:Partial agonist activity at GAL4 DBD-fused PPARgamma LBD (unknown origin) expressed in pG5 luc and pBIND transfected HEK293T cells assessed as transc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Jiangsu Normal University

Curated by ChEMBL
LigandPNGBDBM50606508(CHEMBL5220965)
Affinity DataEC50:  0.0410nMAssay Description:Agonist activity at human GLP-1R expressed in HEK293 cells incubated for 30 mins and assessed as increase in cAMP accumulation measured by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetGlucagon receptor(Human)
Affiliated Tumor Hospital of Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50606510(CHEMBL5219646)
Affinity DataEC50:  2.60nMAssay Description:Agonist activity at human GCGR expressed in HEK293 cells incubated for 30 mins and assessed as increase in cAMP accumulation measured by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50642509(CHEMBL5575427)
Affinity DataKd:  8.30nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

WIPO
LigandPNGBDBM509871(US11124497, Compound 405 | US11524940, Compound 40...)
Affinity DataEC50:  2.09E+3nMAssay Description:The ability of compounds to prevent SARS-CoV-2 coronavirus-induced cell death or cytopathic effect can be assessed via cell viability, using an assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2022
Entry Details
WIPO WO2021250648

LigandPNGBDBM50547430(CHEMBL4753045)
Affinity DataEC50:  7.30E+3nMAssay Description:Activation of human sGC subunit alpha1/beta1 expressed in CHO cells assessed as cGMP production by CASA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Jiangsu Normal University

Curated by ChEMBL
LigandPNGBDBM50554530(CHEMBL4759680)
Affinity DataEC50:  0.210nMAssay Description:Agonist activity at human GLP-1R expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Jiangsu Normal University

Curated by ChEMBL
LigandPNGBDBM50600020(CHEMBL5182173)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at human CCK1R expressed in HEK293 cells assessed as ERK1/2 phosphorylation incubated for 5 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Air Force Medical University

Curated by ChEMBL
LigandPNGBDBM50633647(CHEMBL5411628)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity to paraoxon-inhibited human erythrocyte AChE assessed as dissociation constant preincubated with paraoxon for 15 mins followed by co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM50627991(CHEMBL5423035)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50502347(CHEMBL4584879)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulatory activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assess...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50502355(CHEMBL4593680)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulatory activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assess...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandPNGBDBM50547433(CHEMBL4740488)
Affinity DataEC50:  9.00E+4nMAssay Description:Activation of human sGC subunit alpha1/beta1 expressed in CHO cells assessed as cGMP production by CASA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Jiangsu Normal University

Curated by ChEMBL
LigandPNGBDBM50554578(CHEMBL4795525)
Affinity DataEC50:  0.150nMAssay Description:Agonist activity at human GLP-1R expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 20 mins in presence of 0% HSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Jiangsu Normal University

Curated by ChEMBL
LigandPNGBDBM50554548(CHEMBL4788440)
Affinity DataEC50:  7.30nMAssay Description:Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Jiangsu Normal University

Curated by ChEMBL
LigandPNGBDBM50606514(CHEMBL5220666)
Affinity DataEC50:  0.680nMAssay Description:Agonist activity at human GLP-1R expressed in HEK293 cells incubated for 30 mins and assessed as increase in cAMP accumulation measured by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Jiangsu Normal University

Curated by ChEMBL
LigandPNGBDBM50151284(CHEMBL3770379)
Affinity DataEC50:  24nMAssay Description:Activation of human GLP1R expressed in HEK293 cells preincubated for 30 mins followed by addition of cAMP-d2 conjugate/cryptate conjugate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Harvard Medical School

LigandPNGBDBM50337134(US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...)
Affinity DataKd:  80nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Displayed 1 to 50 (of 4294 total ) | Next | Last >>
Jump to: