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TargetKappa-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212293((1S,9R,10R)-5-amino-20-(cyclopropylmethyl)-6-thia-...)
Affinity DataKi:  0.0700nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212293((1S,9R,10R)-5-amino-20-(cyclopropylmethyl)-6-thia-...)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212297((1S,9R,10R)-5-amino-20-(cyclobutylmethyl)-6-thia-4...)
Affinity DataKi:  0.140nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212291((1S,13R,14R)-24-(cyclobutylmethyl)-4,24-diazahexac...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212296((1S,13R,14R)-24-(cyclopropylmethyl)-4,24-diazahexa...)
Affinity DataKi:  0.190nMAssay Description:Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212293((1S,9R,10R)-5-amino-20-(cyclopropylmethyl)-6-thia-...)
Affinity DataKi:  0.230nMAssay Description:Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212295((1S,13R,14R)-24-methyl-4,24-diazahexacyclo[12.7.3....)
Affinity DataKi:  0.350nMAssay Description:Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212297((1S,9R,10R)-5-amino-20-(cyclobutylmethyl)-6-thia-4...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212299((1S,9R,10R)-5-amino-20-methyl-6-thia-4,20-diazapen...)
Affinity DataKi:  0.490nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212296((1S,13R,14R)-24-(cyclopropylmethyl)-4,24-diazahexa...)
Affinity DataKi:  0.640nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212291((1S,13R,14R)-24-(cyclobutylmethyl)-4,24-diazahexac...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212297((1S,9R,10R)-5-amino-20-(cyclobutylmethyl)-6-thia-4...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212296((1S,13R,14R)-24-(cyclopropylmethyl)-4,24-diazahexa...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212292((1S,13R,14R)-24-(cyclopropylmethyl)-19-methoxy-4,2...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212292((1S,13R,14R)-24-(cyclopropylmethyl)-19-methoxy-4,2...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212299((1S,9R,10R)-5-amino-20-methyl-6-thia-4,20-diazapen...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212291((1S,13R,14R)-24-(cyclobutylmethyl)-4,24-diazahexac...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212299((1S,9R,10R)-5-amino-20-methyl-6-thia-4,20-diazapen...)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212292((1S,13R,14R)-24-(cyclopropylmethyl)-19-methoxy-4,2...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212298((1S,13R,14R)-24-(cyclobutylmethyl)-19-methoxy-4,24...)
Affinity DataKi:  8.70nMAssay Description:Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1B) dopamine receptor(Human)
State Key Laboratory of Drug Research

Curated by ChEMBL
LigandPNGBDBM50088341(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Affinity DataKi: <10nMAssay Description:Antagonist activity at dopamine D5 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Human)
State Key Laboratory of Drug Research

Curated by ChEMBL
LigandPNGBDBM50088341(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Affinity DataKi: <10nMAssay Description:Antagonist activity at dopamine D1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212295((1S,13R,14R)-24-methyl-4,24-diazahexacyclo[12.7.3....)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212295((1S,13R,14R)-24-methyl-4,24-diazahexacyclo[12.7.3....)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212294((1S,13R,14R)-19-methoxy-24-methyl-4,24-diazahexacy...)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407504(CHEMBL5275740)
Affinity DataKi:  40nMAssay Description:Antagonistic activity against (-)-noradrenaline-induced contraction of rat prostatic vas deferens (Alpha-1A adrenergic receptor )More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(1A) dopamine receptor(Human)
State Key Laboratory of Drug Research

Curated by ChEMBL
LigandPNGBDBM50004822((R)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine...)
Affinity DataKi:  73nMAssay Description:Agonist activity at dopamine D1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212298((1S,13R,14R)-24-(cyclobutylmethyl)-19-methoxy-4,24...)
Affinity DataKi:  89nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407504(CHEMBL5275740)
Affinity DataKi:  300nMAssay Description:Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50600(MLS001029919 | N-(3-Chloro-1,4-dioxo-1,4-dihydro-n...)
Affinity DataKi:  300nMAssay Description:Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212298((1S,13R,14R)-24-(cyclobutylmethyl)-19-methoxy-4,24...)
Affinity DataKi:  330nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212294((1S,13R,14R)-19-methoxy-24-methyl-4,24-diazahexacy...)
Affinity DataKi:  340nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212294((1S,13R,14R)-19-methoxy-24-methyl-4,24-diazahexacy...)
Affinity DataKi:  390nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 2(Mouse)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407506(CHEMBL4595333)
Affinity DataKi:  400nMAssay Description:Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSphingosine kinase 2(Mouse)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407507(CHEMBL5281819)
Affinity DataKi:  1.00E+3nMAssay Description:Functional Histamine H3 receptor antagonistic activity in vitro assay on guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSphingosine kinase 2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50443388(CHEMBL3086782 | US9688668, SLR080811)
Affinity DataKi:  1.30E+3nMAssay Description:Functional H2 receptor antagonistic activity in vitro assay on the isolated spontaneously beating guinea-pig right atriumMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50009730((E)-2-Amino-octadec-4-ene-1,3-diol | 2-Amino-octad...)
Affinity DataKi:  3.00E+3nMAssay Description:Antagonistic activity against (-)-noradrenaline-induced contraction of rat prostatic vas deferens (alpha1A receptor)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407505(CHEMBL447685)
Affinity DataKi:  5.00E+3nMAssay Description:Antagonistic activity against (-)-phenylephrine-induced contraction of rat spleen (Alpha-1B adrenergic receptor )More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSphingosine kinase 2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50139649(CHEMBL3764617)
Affinity DataKi:  6.90E+3nMAssay Description:Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSphingosine kinase 2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50312869(4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol | CH...)
Affinity DataKi:  8.00E+3nMAssay Description:Functional H2 receptor antagonistic activity in vitro assay on the isolated spontaneously beating guinea-pig right atriumMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSphingosine kinase 2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50393642(CHEMBL2158685)
Affinity DataKi:  9.80E+3nMAssay Description:Functional Histamine H3 receptor antagonistic activity in vitro assay on guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50443388(CHEMBL3086782 | US9688668, SLR080811)
Affinity DataKi:  1.20E+4nMAssay Description:Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSphingosine kinase 2(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407505(CHEMBL447685)
Affinity DataKi:  1.20E+4nMAssay Description:Functional H2 receptor antagonistic activity in vitro assay on the isolated spontaneously beating guinea-pig right atriumMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50312869(4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol | CH...)
Affinity DataKi:  1.60E+4nMAssay Description:Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)More data for this Ligand-Target Pair
TargetSphingosine kinase 1(Mouse)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407506(CHEMBL4595333)
Affinity DataKi: >2.00E+4nMAssay Description:Functional H2 receptor antagonistic activity in vitro assay on the isolated spontaneously beating guinea-pig right atriumMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSphingosine kinase 1(Mouse)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50407507(CHEMBL5281819)
Affinity DataKi:  2.00E+4nMAssay Description:Functional Histamine H3 receptor antagonistic activity in vitro assay on guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSphingosine kinase 1(Human)
Shandong First Medical University & Shandong Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50139649(CHEMBL3764617)
Affinity DataKi:  2.70E+4nMAssay Description:Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDelta-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212291((1S,13R,14R)-24-(cyclobutylmethyl)-4,24-diazahexac...)
Affinity DataIC50:  0.600nMAssay Description:Antagonist activity at human delta opioid receptor expressed in CHO membrane assessed as inhibition of SNC80-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50499123(CHEMBL3734938)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu, Tyr)4:1 substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50499104(CHEMBL3736273)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu, Tyr)4:1 substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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