Compile Data Set for Download or QSAR
Found 1001 with Last Name = 'yeoh' and Initial = 't'
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589753(US11559538, Example 16 | US11559538, Example 208 |...)
Show SMILES CCCOc1nc(c(F)cc1OC)-c1cncc(c1)C1COB(O)C1
Show InChI InChI=1S/C17H20BFN2O4/c1-3-4-24-17-15(23-2)6-14(19)16(21-17)12-5-11(8-20-9-12)13-7-18(22)25-10-13/h5-6,8-9,13,22H,3-4,7,10H2,1-2H3
Affinity DataIC50: 0.0500nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM139691(US8895544, 1)
Show SMILES CCc1cc(O)c(F)cc1-c1ccc2c(n[nH]c2c1)-c1nc2CN(CCc2[nH]1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H23F2N5O2/c1-2-15-12-25(36)21(30)13-20(15)17-5-8-19-23(11-17)33-34-26(19)27-31-22-9-10-35(14-24(22)32-27)28(37)16-3-6-18(29)7-4-16/h3-8,11-13,36H,2,9-10,14H2,1H3,(H,31,32)(H,33,34)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of GST tagged human recombinant JAK1 catalytic domain expressed in baculovirus using peptide substrate preincubated for 60 mins followed b...More data for this Ligand-Target Pair
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589753(US11559538, Example 16 | US11559538, Example 208 |...)
Show SMILES CCCOc1nc(c(F)cc1OC)-c1cncc(c1)C1COB(O)C1
Show InChI InChI=1S/C17H20BFN2O4/c1-3-4-24-17-15(23-2)6-14(19)16(21-17)12-5-11(8-20-9-12)13-7-18(22)25-10-13/h5-6,8-9,13,22H,3-4,7,10H2,1-2H3
Affinity DataIC50: 0.120nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589753(US11559538, Example 16 | US11559538, Example 208 |...)
Show SMILES CCCOc1nc(c(F)cc1OC)-c1cncc(c1)C1COB(O)C1
Show InChI InChI=1S/C17H20BFN2O4/c1-3-4-24-17-15(23-2)6-14(19)16(21-17)12-5-11(8-20-9-12)13-7-18(22)25-10-13/h5-6,8-9,13,22H,3-4,7,10H2,1-2H3
Affinity DataIC50: 0.220nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589895(US11559538, Example 147 | US11559538, Example 148)
Show SMILES CCCOc1cc(ccc1OC)-c1nc(ns1)C1COB(O)C1
Show InChI InChI=1S/C15H19BN2O4S/c1-3-6-21-13-7-10(4-5-12(13)20-2)15-17-14(18-23-15)11-8-16(19)22-9-11/h4-5,7,11,19H,3,6,8-9H2,1-2H3
Affinity DataIC50: 0.240nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589886(US11559538, Example 138 | US11559538, Example 139 ...)
Show SMILES CCOc1cc(ccc1OC)-c1cncc(C2COB(O)C2)c1C(F)F
Show InChI InChI=1S/C18H20BF2NO4/c1-3-25-16-6-11(4-5-15(16)24-2)13-8-22-9-14(17(13)18(20)21)12-7-19(23)26-10-12/h4-6,8-9,12,18,23H,3,7,10H2,1-2H3
Affinity DataIC50: 0.25nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589754(US11559538, Example 17 | US11559538, Example 50)
Show SMILES CCCOc1cc(ccc1OC(F)F)-c1cncc(c1)C1COB(O)C1
Show InChI InChI=1S/C18H20BF2NO4/c1-2-5-24-17-7-12(3-4-16(17)26-18(20)21)13-6-14(10-22-9-13)15-8-19(23)25-11-15/h3-4,6-7,9-10,15,18,23H,2,5,8,11H2,1H3
Affinity DataIC50: 0.280nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589803(US11559538, Example 60 | US11559538, Example 61 | ...)
Show SMILES CCCOc1nc(ccc1OC)-c1cncc(c1)C1COB(O)C1
Show InChI InChI=1S/C17H21BN2O4/c1-3-6-23-17-16(22-2)5-4-15(20-17)13-7-12(9-19-10-13)14-8-18(21)24-11-14/h4-5,7,9-10,14,21H,3,6,8,11H2,1-2H3
Affinity DataIC50: 0.280nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-4(Human)
Pfizer Inc.

US Patent
LigandPNGBDBM589948(US11559538, Example 195 | US11559538, Example 196)
Show SMILES CCCOc1cc(ccc1OC)-c1nc(OCCO)cc(n1)C1COB(O)C1
Show InChI InChI=1S/C19H25BN2O6/c1-3-7-26-17-9-13(4-5-16(17)25-2)19-21-15(14-11-20(24)28-12-14)10-18(22-19)27-8-6-23/h4-5,9-10,14,23-24H,3,6-8,11-12H2,1-2H3
Affinity DataIC50: 0.290nMMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589830(US11559538, Example 84 | US11559538, Example 85)
Show SMILES CCCOc1cc(ccc1OC)-c1cncc(C2COB(O)C2)c1C
Show InChI InChI=1S/C19H24BNO4/c1-4-7-24-19-8-14(5-6-18(19)23-3)16-10-21-11-17(13(16)2)15-9-20(22)25-12-15/h5-6,8,10-11,15,22H,4,7,9,12H2,1-3H3
Affinity DataIC50: 0.290nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM139691(US8895544, 1)
Show SMILES CCc1cc(O)c(F)cc1-c1ccc2c(n[nH]c2c1)-c1nc2CN(CCc2[nH]1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H23F2N5O2/c1-2-15-12-25(36)21(30)13-20(15)17-5-8-19-23(11-17)33-34-26(19)27-31-22-9-10-35(14-24(22)32-27)28(37)16-3-6-18(29)7-4-16/h3-8,11-13,36H,2,9-10,14H2,1H3,(H,31,32)(H,33,34)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of GST tagged human recombinant JAK2 catalytic domain expressed in baculovirus using peptide substrate preincubated for 60 mins followed b...More data for this Ligand-Target Pair
TargetInterferon gamma receptor 1(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589948(US11559538, Example 195 | US11559538, Example 196)
Show SMILES CCCOc1cc(ccc1OC)-c1nc(OCCO)cc(n1)C1COB(O)C1
Show InChI InChI=1S/C19H25BN2O6/c1-3-7-26-17-9-13(4-5-16(17)25-2)19-21-15(14-11-20(24)28-12-14)10-18(22-19)27-8-6-23/h4-5,9-10,14,23-24H,3,6-8,11-12H2,1-2H3
Affinity DataIC50: 0.330nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589803(US11559538, Example 60 | US11559538, Example 61 | ...)
Show SMILES CCCOc1nc(ccc1OC)-c1cncc(c1)C1COB(O)C1
Show InChI InChI=1S/C17H21BN2O4/c1-3-6-23-17-16(22-2)5-4-15(20-17)13-7-12(9-19-10-13)14-8-18(21)24-11-14/h4-5,7,9-10,14,21H,3,6,8,11H2,1-2H3
Affinity DataIC50: 0.340nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589948(US11559538, Example 195 | US11559538, Example 196)
Show SMILES CCCOc1cc(ccc1OC)-c1nc(OCCO)cc(n1)C1COB(O)C1
Show InChI InChI=1S/C19H25BN2O6/c1-3-7-26-17-9-13(4-5-16(17)25-2)19-21-15(14-11-20(24)28-12-14)10-18(22-19)27-8-6-23/h4-5,9-10,14,23-24H,3,6-8,11-12H2,1-2H3
Affinity DataIC50: 0.340nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589782(US11559538, Example 42)
Show SMILES CCCOc1c(OC)ccc(-c2cccc(c2)C2COB(O)C2)c1C#N
Show InChI InChI=1S/C20H22BNO4/c1-3-9-25-20-18(12-22)17(7-8-19(20)24-2)15-6-4-5-14(10-15)16-11-21(23)26-13-16/h4-8,10,16,23H,3,9,11,13H2,1-2H3
Affinity DataIC50: 0.350nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-4(Human)
Pfizer Inc.

US Patent
LigandPNGBDBM589948(US11559538, Example 195 | US11559538, Example 196)
Show SMILES CCCOc1cc(ccc1OC)-c1nc(OCCO)cc(n1)C1COB(O)C1
Show InChI InChI=1S/C19H25BN2O6/c1-3-7-26-17-9-13(4-5-16(17)25-2)19-21-15(14-11-20(24)28-12-14)10-18(22-19)27-8-6-23/h4-5,9-10,14,23-24H,3,6-8,11-12H2,1-2H3
Affinity DataIC50: 0.360nMMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589780(US11559538, Example 40)
Show SMILES COc1ccc(cc1OCCCF)-c1cccc(c1)C1COB(O)C1
Show InChI InChI=1S/C19H22BFO4/c1-23-18-7-6-16(11-19(18)24-9-3-8-21)14-4-2-5-15(10-14)17-12-20(22)25-13-17/h2,4-7,10-11,17,22H,3,8-9,12-13H2,1H3
Affinity DataIC50: 0.370nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterferon gamma receptor 1(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589886(US11559538, Example 138 | US11559538, Example 139 ...)
Show SMILES CCOc1cc(ccc1OC)-c1cncc(C2COB(O)C2)c1C(F)F
Show InChI InChI=1S/C18H20BF2NO4/c1-3-25-16-6-11(4-5-15(16)24-2)13-8-22-9-14(17(13)18(20)21)12-7-19(23)26-10-12/h4-6,8-9,12,18,23H,3,7,10H2,1-2H3
Affinity DataIC50: 0.400nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50234911(CHEMBL3928932)
Show SMILES CCc1cc(O)ccc1-c1ccc2c(n[nH]c2c1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C22H18N4O/c1-2-13-11-15(27)8-10-16(13)14-7-9-17-20(12-14)25-26-21(17)22-23-18-5-3-4-6-19(18)24-22/h3-12,27H,2H2,1H3,(H,23,24)(H,25,26)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of GST tagged human recombinant JAK1 catalytic domain expressed in baculovirus using peptide substrate preincubated for 60 mins followed b...More data for this Ligand-Target Pair
TargetInterferon gamma receptor 1(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589830(US11559538, Example 84 | US11559538, Example 85)
Show SMILES CCCOc1cc(ccc1OC)-c1cncc(C2COB(O)C2)c1C
Show InChI InChI=1S/C19H24BNO4/c1-4-7-24-19-8-14(5-6-18(19)23-3)16-10-21-11-17(13(16)2)15-9-20(22)25-12-15/h5-6,8,10-11,15,22H,4,7,9,12H2,1-3H3
Affinity DataIC50: 0.440nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589895(US11559538, Example 147 | US11559538, Example 148)
Show SMILES CCCOc1cc(ccc1OC)-c1nc(ns1)C1COB(O)C1
Show InChI InChI=1S/C15H19BN2O4S/c1-3-6-21-13-7-10(4-5-12(13)20-2)15-17-14(18-23-15)11-8-16(19)22-9-11/h4-5,7,11,19H,3,6,8-9H2,1-2H3
Affinity DataIC50: 0.440nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterferon gamma receptor 1(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589754(US11559538, Example 17 | US11559538, Example 50)
Show SMILES CCCOc1cc(ccc1OC(F)F)-c1cncc(c1)C1COB(O)C1
Show InChI InChI=1S/C18H20BF2NO4/c1-2-5-24-17-7-12(3-4-16(17)26-18(20)21)13-6-14(10-22-9-13)15-8-19(23)25-11-15/h3-4,6-7,9-10,15,18,23H,2,5,8,11H2,1H3
Affinity DataIC50: 0.470nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589811(US11559538, Example 68)
Show SMILES COc1ccc(cc1OC1CSC1)-c1cncc(c1)C1COB(O)C1
Show InChI InChI=1S/C18H20BNO4S/c1-22-17-3-2-12(5-18(17)24-16-10-25-11-16)13-4-14(8-20-7-13)15-6-19(21)23-9-15/h2-5,7-8,15-16,21H,6,9-11H2,1H3
Affinity DataIC50: 0.470nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589897(US11559538, Example 149)
Show SMILES COc1ccc(cc1OC1CCCC1)-c1cncc(c1)C1COB(O)C1
Show InChI InChI=1S/C20H24BNO4/c1-24-19-7-6-14(9-20(19)26-18-4-2-3-5-18)15-8-16(12-22-11-15)17-10-21(23)25-13-17/h6-9,11-12,17-18,23H,2-5,10,13H2,1H3
Affinity DataIC50: 0.490nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50234908(CHEMBL4093813)
Show SMILES CCc1cc(O)ccc1-c1ccc2c(n[nH]c2c1)-c1nc2CCN(Cc2[nH]1)C(C)=O
Show InChI InChI=1S/C23H23N5O2/c1-3-14-10-16(30)5-7-17(14)15-4-6-18-20(11-15)26-27-22(18)23-24-19-8-9-28(13(2)29)12-21(19)25-23/h4-7,10-11,30H,3,8-9,12H2,1-2H3,(H,24,25)(H,26,27)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of GST tagged human recombinant JAK1 catalytic domain expressed in baculovirus using peptide substrate preincubated for 60 mins followed b...More data for this Ligand-Target Pair
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589839(US11559538, Example 93)
Show SMILES COc1cnc(nc1OC1CCCC1)-c1cccc(c1)C1COB(O)C1
Show InChI InChI=1S/C19H23BN2O4/c1-24-17-11-21-18(22-19(17)26-16-7-2-3-8-16)14-6-4-5-13(9-14)15-10-20(23)25-12-15/h4-6,9,11,15-16,23H,2-3,7-8,10,12H2,1H3
Affinity DataIC50: 0.5nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589740(US11559538, Example 4)
Show SMILES CCCOc1cc(ccc1OC)-c1cncc(c1)[C@@H]1COB(O)C1
Show InChI InChI=1S/C18H22BNO4/c1-3-6-23-18-8-13(4-5-17(18)22-2)14-7-15(11-20-10-14)16-9-19(21)24-12-16/h4-5,7-8,10-11,16,21H,3,6,9,12H2,1-2H3/t16-/m0/s1
Affinity DataIC50: 0.5nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589958(US11559538, Example 205)
Show SMILES CCOc1cc(ccc1OC)-c1c(C)ncc(C2COB(O)C2)c1C
Show InChI InChI=1S/C19H24BNO4/c1-5-24-18-8-14(6-7-17(18)23-4)19-12(2)16(10-21-13(19)3)15-9-20(22)25-11-15/h6-8,10,15,22H,5,9,11H2,1-4H3
Affinity DataIC50: 0.520nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589776(US11559538, Example 34)
Show SMILES CCCOc1cc(ccc1OC)-c1cncc(c1)C1COB(O)C1
Show InChI InChI=1S/C18H22BNO4/c1-3-6-23-18-8-13(4-5-17(18)22-2)14-7-15(11-20-10-14)16-9-19(21)24-12-16/h4-5,7-8,10-11,16,21H,3,6,9,12H2,1-2H3
Affinity DataIC50: 0.520nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589803(US11559538, Example 60 | US11559538, Example 61 | ...)
Show SMILES CCCOc1nc(ccc1OC)-c1cncc(c1)C1COB(O)C1
Show InChI InChI=1S/C17H21BN2O4/c1-3-6-23-17-16(22-2)5-4-15(20-17)13-7-12(9-19-10-13)14-8-18(21)24-11-14/h4-5,7,9-10,14,21H,3,6,8,11H2,1-2H3
Affinity DataIC50: 0.530nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterferon gamma receptor 1(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589803(US11559538, Example 60 | US11559538, Example 61 | ...)
Show SMILES CCCOc1nc(ccc1OC)-c1cncc(c1)C1COB(O)C1
Show InChI InChI=1S/C17H21BN2O4/c1-3-6-23-17-16(22-2)5-4-15(20-17)13-7-12(9-19-10-13)14-8-18(21)24-11-14/h4-5,7,9-10,14,21H,3,6,8,11H2,1-2H3
Affinity DataIC50: 0.530nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-4(Human)
Pfizer Inc.

US Patent
LigandPNGBDBM589753(US11559538, Example 16 | US11559538, Example 208 |...)
Show SMILES CCCOc1nc(c(F)cc1OC)-c1cncc(c1)C1COB(O)C1
Show InChI InChI=1S/C17H20BFN2O4/c1-3-4-24-17-15(23-2)6-14(19)16(21-17)12-5-11(8-20-9-12)13-7-18(22)25-10-13/h5-6,8-9,13,22H,3-4,7,10H2,1-2H3
Affinity DataIC50: 0.540nMMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589821(US11559538, Example 78 | US11559538, Example 79 | ...)
Show SMILES COc1ccc(cc1OC1CCSC1)-c1cncc(c1)C1COB(O)C1
Show InChI InChI=1S/C19H22BNO4S/c1-23-18-3-2-13(7-19(18)25-17-4-5-26-12-17)14-6-15(10-21-9-14)16-8-20(22)24-11-16/h2-3,6-7,9-10,16-17,22H,4-5,8,11-12H2,1H3
Affinity DataIC50: 0.550nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589825(US11559538, Example 81 | US11559538, Example 82)
Show SMILES CCCOc1c(OC)ccc(c1F)-c1cncc(c1)C1COB(O)C1
Show InChI InChI=1S/C18H21BFNO4/c1-3-6-24-18-16(23-2)5-4-15(17(18)20)13-7-12(9-21-10-13)14-8-19(22)25-11-14/h4-5,7,9-10,14,22H,3,6,8,11H2,1-2H3
Affinity DataIC50: 0.550nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterferon gamma receptor 1(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589830(US11559538, Example 84 | US11559538, Example 85)
Show SMILES CCCOc1cc(ccc1OC)-c1cncc(C2COB(O)C2)c1C
Show InChI InChI=1S/C19H24BNO4/c1-4-7-24-19-8-14(5-6-18(19)23-3)16-10-21-11-17(13(16)2)15-9-20(22)25-12-15/h5-6,8,10-11,15,22H,4,7,9,12H2,1-3H3
Affinity DataIC50: 0.560nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589892(US11559538, Example 144)
Show SMILES CCOc1cc(ccc1SC)-c1cncc(c1)C1COB(O)C1
Show InChI InChI=1S/C17H20BNO3S/c1-3-21-16-7-12(4-5-17(16)23-2)13-6-14(10-19-9-13)15-8-18(20)22-11-15/h4-7,9-10,15,20H,3,8,11H2,1-2H3
Affinity DataIC50: 0.580nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterferon gamma receptor 1(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589758(US11559538, Example 189 | US11559538, Example 21 |...)
Show SMILES CCOc1cc(ccc1OC)-c1cncc(C2COB(O)C2)c1C
Show InChI InChI=1S/C18H22BNO4/c1-4-23-18-7-13(5-6-17(18)22-3)15-9-20-10-16(12(15)2)14-8-19(21)24-11-14/h5-7,9-10,14,21H,4,8,11H2,1-3H3
Affinity DataIC50: 0.600nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589856(US11559538, Example 110)
Show SMILES CCCCCOc1cc(ccc1OC)-c1cccc(c1)C1COB(O)C1
Show InChI InChI=1S/C21H27BO4/c1-3-4-5-11-25-21-13-18(9-10-20(21)24-2)16-7-6-8-17(12-16)19-14-22(23)26-15-19/h6-10,12-13,19,23H,3-5,11,14-15H2,1-2H3
Affinity DataIC50: 0.610nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-4(Human)
Pfizer Inc.

US Patent
LigandPNGBDBM589760(US11559538, Example 124 | US11559538, Example 23 |...)
Show SMILES CCCOc1cc(ccc1OC)-c1nc(cc(n1)C(F)(F)F)C1COB(O)C1
Show InChI InChI=1S/C18H20BF3N2O4/c1-3-6-27-15-7-11(4-5-14(15)26-2)17-23-13(12-9-19(25)28-10-12)8-16(24-17)18(20,21)22/h4-5,7-8,12,25H,3,6,9-10H2,1-2H3
Affinity DataIC50: 0.610nMMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589743(US11559538, Example 193 | US11559538, Example 36 |...)
Show SMILES COc1ccc(cc1OC1CC1)-c1cncc(c1)C1COB(O)C1
Show InChI InChI=1S/C18H20BNO4/c1-22-17-5-2-12(7-18(17)24-16-3-4-16)13-6-14(10-20-9-13)15-8-19(21)23-11-15/h2,5-7,9-10,15-16,21H,3-4,8,11H2,1H3
Affinity DataIC50: 0.630nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589758(US11559538, Example 189 | US11559538, Example 21 |...)
Show SMILES CCOc1cc(ccc1OC)-c1cncc(C2COB(O)C2)c1C
Show InChI InChI=1S/C18H22BNO4/c1-4-23-18-7-13(5-6-17(18)22-3)15-9-20-10-16(12(15)2)14-8-19(21)24-11-14/h5-7,9-10,14,21H,4,8,11H2,1-3H3
Affinity DataIC50: 0.640nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterferon gamma receptor 1(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589919(US11559538, Example 167 | US11559538, Example 168)
Show SMILES CCCOc1c(OC)ccc(-c2cncc(c2)C2COB(O)C2)c1OC
Show InChI InChI=1S/C19H24BNO5/c1-4-7-25-19-17(23-2)6-5-16(18(19)24-3)14-8-13(10-21-11-14)15-9-20(22)26-12-15/h5-6,8,10-11,15,22H,4,7,9,12H2,1-3H3
Affinity DataIC50: 0.640nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterleukin-4(Human)
Pfizer Inc.

US Patent
LigandPNGBDBM589754(US11559538, Example 17 | US11559538, Example 50)
Show SMILES CCCOc1cc(ccc1OC(F)F)-c1cncc(c1)C1COB(O)C1
Show InChI InChI=1S/C18H20BF2NO4/c1-2-5-24-17-7-12(3-4-16(17)26-18(20)21)13-6-14(10-22-9-13)15-8-19(23)25-11-15/h3-4,6-7,9-10,15,18,23H,2,5,8,11H2,1H3
Affinity DataIC50: 0.650nMMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589738(US11559538, Example 2)
Show SMILES CCOc1cc(ccc1OC)-c1cncc(c1)[C@H]1COB(O)C1
Show InChI InChI=1S/C17H20BNO4/c1-3-22-17-7-12(4-5-16(17)21-2)13-6-14(10-19-9-13)15-8-18(20)23-11-15/h4-7,9-10,15,20H,3,8,11H2,1-2H3/t15-/m1/s1
Affinity DataIC50: 0.670nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589933(US11559538, Example 181)
Show SMILES COc1ccc(cc1OC1CC1)-c1nc(ns1)C1COB(O)C1
Show InChI InChI=1S/C15H17BN2O4S/c1-20-12-5-2-9(6-13(12)22-11-3-4-11)15-17-14(18-23-15)10-7-16(19)21-8-10/h2,5-6,10-11,19H,3-4,7-8H2,1H3
Affinity DataIC50: 0.680nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589867(US11559538, Example 121)
Show SMILES CCOc1nc(ccc1OC)-c1cccc(c1)C1COB(O)C1
Show InChI InChI=1S/C17H20BNO4/c1-3-22-17-16(21-2)8-7-15(19-17)13-6-4-5-12(9-13)14-10-18(20)23-11-14/h4-9,14,20H,3,10-11H2,1-2H3
Affinity DataIC50: 0.690nMAssay Description:Cytokine inhibitory activity is determined by measuring the effect of test agent on the release of the cytokines IL-4, IL-13 and IFNγ from human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterferon gamma receptor 1(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589739(US11559538, Example 3)
Show SMILES CCOc1cc(ccc1OC)-c1cncc(c1)[C@@H]1COB(O)C1
Show InChI InChI=1S/C17H20BNO4/c1-3-22-17-7-12(4-5-16(17)21-2)13-6-14(10-19-9-13)15-8-18(20)23-11-15/h4-7,9-10,15,20H,3,8,11H2,1-2H3/t15-/m0/s1
Affinity DataIC50: 0.700nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterferon gamma receptor 1(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589808(US11559538, Example 65 | US11559538, Example 66 | ...)
Show SMILES COc1ccc(cc1OC1CCCC1)-c1cccc(n1)C1COB(O)C1
Show InChI InChI=1S/C20H24BNO4/c1-24-19-10-9-14(11-20(19)26-16-5-2-3-6-16)17-7-4-8-18(22-17)15-12-21(23)25-13-15/h4,7-11,15-16,23H,2-3,5-6,12-13H2,1H3
Affinity DataIC50: 0.710nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterferon gamma receptor 1(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589743(US11559538, Example 193 | US11559538, Example 36 |...)
Show SMILES COc1ccc(cc1OC1CC1)-c1cncc(c1)C1COB(O)C1
Show InChI InChI=1S/C18H20BNO4/c1-22-17-5-2-12(7-18(17)24-16-3-4-16)13-6-14(10-20-9-13)15-8-19(21)23-11-15/h2,5-7,9-10,15-16,21H,3-4,8,11H2,1H3
Affinity DataIC50: 0.710nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetInterferon gamma receptor 1(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM589751(US11559538, Example 15 | US11559538, Example 47)
Show SMILES CCOc1cc(c(Cl)cc1OC)-c1cncc(c1)C1COB(O)C1
Show InChI InChI=1S/C17H19BClNO4/c1-3-23-17-5-14(15(19)6-16(17)22-2)12-4-11(8-20-9-12)13-7-18(21)24-10-13/h4-6,8-9,13,21H,3,7,10H2,1-2H3
Affinity DataIC50: 0.710nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Displayed 1 to 50 (of 1001 total ) | Next | Last >>
Jump to: