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TargetSqualene synthase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338903(Ethyl 1-{4-[{4-chloro-2-[(2-fluorophenyl)(hydroxy)...)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338880(Ethyl 1-{4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)...)
Affinity DataIC50: 0.850nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338892(Benzyl 4-{4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338907(Ethyl 1-{4-[{4-chloro-2-[hydroxy(2-methoxyphenyl)-...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338910(1-{3-[{4-Chloro-2-[(2,3-dimethoxyphenyl)hydroxymet...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338883(1-{4-[{4-Chloro-2-[(2-chlorophenyl)(hydroxy)methyl...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338919(1-{3-[{4-Chloro-2-[(2,3-dimethoxyphenyl)hydroxymet...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338934(1-{4-[{4-Chloro-2-[hydroxy(2-methoxyphenyl)methyl]...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351073(CHEMBL1819477)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351091(CHEMBL1819577)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35751(cis-1,2-diaminocyclohexane derivative, 8h)
Affinity DataIC50: 1.40nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351081(CHEMBL1819567)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSqualene synthase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338887(N-Butyl-1-{4-[{4-chloro-2-[(2-chlorophenyl)(hydrox...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351079(CHEMBL1819565)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351083(CHEMBL1819569)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSqualene synthase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338925(1-{4-[{4-Chloro-2-[hydroxy(2-methoxyphenyl)methyl]...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255631(N-[(1R,2R,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSqualene synthase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338905(Ethyl 1-{4-[{4-chloro-2-[(2-chloro-4-fluorophenyl)...)
Affinity DataIC50: 2nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338937(1-{3-[{4-Chloro-2-[(2,3-dimethoxyphenyl)hydroxymet...)
Affinity DataIC50: 2nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35756(cis-1,2-diaminocyclohexane derivative, 8m)
Affinity DataIC50: 2.10nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255577(N-{(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35743(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Affinity DataIC50: 2.30nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255205(N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35743(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSqualene synthase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338891(Ethyl 4-{4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338885(1-{4-[{4-Chloro-2-[(2-chlorophenyl)(hydroxy)methyl...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351094(CHEMBL1819580)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255207(N-{(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351077(CHEMBL1819563)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351092(CHEMBL1819578)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255159(N-{(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSqualene synthase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338916(Ethyl 1-{4-[{4-chloro-2-[hydroxy(2-methoxyphenyl)-...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338928(1-{3-[{4-Chloro-2-[(2,3-dimethoxyphenyl)hydroxymet...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255204(N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351088(CHEMBL1819574)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351088(CHEMBL1819574)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35759(cis-1,2-diaminocyclohexane derivative, 8p)
Affinity DataIC50: 3.20nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255576(N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351075(CHEMBL1819561)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351085(CHEMBL1819571)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351085(CHEMBL1819571)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35753(cis-1,2-diaminocyclohexane derivative, 8j)
Affinity DataIC50: 3.5nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255206(N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255575(N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSqualene synthase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338886(1-{4-[{4-Chloro-2-[(2-chlorophenyl)(hydroxy)methyl...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351095(CHEMBL1819581)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351093(CHEMBL1819579)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255578(N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255158(N-[(1R,2S,5S)-5-(tert-Butylcarbamoyl)-2-{[(5-chlor...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50351086(CHEMBL1819572)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
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