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TargetTranslocator protein(Rat)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50122293(CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...)
Affinity DataKi:  0.0430nMAssay Description:In vitro binding affinity for PBR (peripheral benzodiazepine receptor) in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rat)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50122294(CHEMBL292092 | N-(5-fluoro-2-phenoxyphenyl)-N-(2-(...)
Affinity DataKi:  0.0780nMAssay Description:In vitro inhibition of [11C]2 binding to Peripheral benzodiazepine receptor (PBR) in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rat)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50122293(CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...)
Affinity DataKi:  0.160nMAssay Description:In vitro inhibition of [11C]2 binding to Peripheral benzodiazepine receptor (PBR) in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rat)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50122295(CHEMBL63065 | N-(2-Fluoromethoxy-5-methoxy-benzyl)...)
Affinity DataKi:  0.170nMAssay Description:In vitro inhibition of [11C]2 binding to Peripheral benzodiazepine receptor (PBR) in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50122293(CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...)
Affinity DataKi:  0.188nMAssay Description:In vitro binding affinity for PBR (peripheral benzodiazepine receptor) in monkey brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Rat)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50312840(CHEMBL1076680 | US9139546, 16 | [11C](3',5'-dichlo...)
Affinity DataKi:  0.270nMAssay Description:Binding affinity to rat brain CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataKi:  0.340nMAssay Description:Binding affinity to mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50301822(5-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to mGluR1 by PET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50301822(5-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50093793(E-2006 | Lemborexant)
Affinity DataKi:  0.440nMAssay Description:Binding affinity to human OX2R expressed in HEK-293 cells assessed as inhibition of orexin A-induced calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
TargetTranslocator protein(Rat)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50266889(CHEMBL513922 | N-benzyl-N-ethyl-2-(7-methyl-8-oxo-...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [11C]-PK-11195 from TPSO in Sprague-Dawley rat brain homogenate after 30 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rat)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50054139((R)1-(2-Chloro-phenyl)-isoquinoline-3-carboxylic a...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [11C]-PK-11195 from TPSO in Sprague-Dawley rat brain homogenate after 30 mins by gamma countingMore data for this Ligand-Target Pair
TargetTranslocator protein(Rat)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM22032(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Affinity DataKi:  0.830nMAssay Description:In vitro inhibition of [11C]2 binding to Peripheral benzodiazepine receptor (PBR) in rat brainMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50333368(CHEMBL1645348 | [11C]-cis-(3-ethyl-2-methylquinoli...)
Affinity DataKi:  0.870nMAssay Description:Binding affinity to mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50333368(CHEMBL1645348 | [11C]-cis-(3-ethyl-2-methylquinoli...)
Affinity DataKi:  0.870nMAssay Description:Binding affinity to mGluR1 by PET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50093788(CHEMBL3585957)
Affinity DataKi:  2nMAssay Description:Binding affinity to human OX1R by radioligand displacement binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50273942(4-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...)
Affinity DataKi:  2nMAssay Description:Binding affinity to mGluR1 by PET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50093815(CHEMBL3585948)
Affinity DataKi:  2nMAssay Description:Binding affinity to human OX2R by radioligand displacement binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Rat)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50312841(CHEMBL1081609 | US9139546, 30 | [11C](3',5'-dichlo...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to rat brain CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50093791(CHEMBL3585955)
Affinity DataKi:  3nMAssay Description:Binding affinity to human OX2R by radioligand displacement binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50093793(E-2006 | Lemborexant)
Affinity DataKi:  3nMAssay Description:Binding affinity to human OX2R by radioligand displacement binding assayMore data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50093795(CHEMBL3585952)
Affinity DataKi:  3nMAssay Description:Binding affinity to human OX1R by radioligand displacement binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50273942(4-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50093798(CHEMBL3585951)
Affinity DataKi:  4nMAssay Description:Binding affinity to human OX2R by radioligand displacement binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50093788(CHEMBL3585957)
Affinity DataKi:  4nMAssay Description:Binding affinity to human OX2R by radioligand displacement binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50093790(CHEMBL3585956)
Affinity DataKi:  4nMAssay Description:Binding affinity to human OX2R by radioligand displacement binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50312838(CHEMBL1081623 | SCH-225336 | [11C]N-(1-(4-(4-metho...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity to human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50292929(CHEMBL455136 | almorexant)
Affinity DataKi:  4.70nMAssay Description:Displacement of [125I]-Orexin A from human OX2R expressed in CHO cells after 30 mins by topcount analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rat)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50144889(CHEMBL72521 | N-(5-Fluoro-2-phenoxy-phenyl)-N-(2-i...)
Affinity DataKi:  4.80nMAssay Description:In vitro inhibition of [11C]2 binding to Peripheral benzodiazepine receptor (PBR) in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50333371(CHEMBL1645351 | CHEMBL1771388 | [11C]-6-N-cyclohex...)
Affinity DataKi:  4.80nMAssay Description:Binding affinity to mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50333371(CHEMBL1645351 | CHEMBL1771388 | [11C]-6-N-cyclohex...)
Affinity DataKi:  4.80nMAssay Description:Binding affinity to mGluR1 by PET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50029064(CHEMBL3343259)
Affinity DataKi:  5nMAssay Description:Binding affinity to human OX2R by radioligand displacement binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50029065(CHEMBL3343260)
Affinity DataKi:  5nMAssay Description:Displacement of [125I]-Orexin A from human OX2R expressed in CHO cells after 30 mins by topcount analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rat)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50401000(CHEMBL2206282)
Affinity DataKi:  5.10nMAssay Description:Displacement of [11C]-PK-11195 from TPSO in Sprague-Dawley rat brain homogenate after 30 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Rat)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50301520(4-fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)th...)
Affinity DataKi:  5.40nMAssay Description:Displacement of 4-[18F]fluoro-N-[4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl]-N-methylbenzamide from mGluR1 in Sprague-Dawley rat brain hom...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50093793(E-2006 | Lemborexant)
Affinity DataKi:  5.70nMAssay Description:Binding affinity to human OX1R expressed in HEK-293 cells assessed as inhibition of orexin A-induced calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50093793(E-2006 | Lemborexant)
Affinity DataKi:  6nMAssay Description:Binding affinity to human OX1R by radioligand displacement binding assayMore data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50093798(CHEMBL3585951)
Affinity DataKi:  6nMAssay Description:Binding affinity to human OX1R by radioligand displacement binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50093795(CHEMBL3585952)
Affinity DataKi:  6nMAssay Description:Binding affinity to human OX2R by radioligand displacement binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50093900(CHEMBL3585946)
Affinity DataKi:  7nMAssay Description:Binding affinity to human OX2R by radioligand displacement binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50093791(CHEMBL3585955)
Affinity DataKi:  7nMAssay Description:Binding affinity to human OX1R by radioligand displacement binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50094022(CHEMBL3585940)
Affinity DataKi:  7nMAssay Description:Binding affinity to human OX2R by radioligand displacement binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50029044(CHEMBL3343242)
Affinity DataKi:  7.20nMAssay Description:Displacement of [125I]-Orexin A from human OX1R expressed in CHO cells after 30 mins by topcount analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50029044(CHEMBL3343242)
Affinity DataKi:  7.20nMAssay Description:Displacement of [125I]-Orexin A from human OX2R expressed in CHO cells after 30 mins by topcount analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50094039(CHEMBL3585938)
Affinity DataKi:  8nMAssay Description:Binding affinity to human OX2R by radioligand displacement binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50093792(CHEMBL3585954)
Affinity DataKi:  8nMAssay Description:Binding affinity to human OX2R by radioligand displacement binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50417257(SB-649868)
Affinity DataKi:  8.5nMAssay Description:Displacement of [125I]-Orexin A from human OX2R expressed in CHO cells after 30 mins by topcount analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50094006(CHEMBL3585942)
Affinity DataKi:  9nMAssay Description:Binding affinity to human OX2R by radioligand displacement binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Human)
National Institute of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50312837(CHEMBL1081610 | [11C]8-butoxy-N-cyclohexyl-7-metho...)
Affinity DataKi:  9.60nMAssay Description:Binding affinity to human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50093780(CHEMBL3585936)
Affinity DataKi:  10nMAssay Description:Binding affinity to human OX2R by radioligand displacement binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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