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TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50315967(N-(3,4-difluorophenylsulfonyl)-3-(2-(2-(naphthalen...)
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35767(cis-1,2-diaminocyclohexane derivative, 5h)
Affinity DataIC50: 0.430nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 6(Rhesus macaque)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50463591(CHEMBL4248604)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of monkey CCR6 expressed in CHO cells assessed as decrease in CCL20-induced reduction of forskolin-stimulated cAMP accumulation preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50340866(2-(4-(5-chloro-1H-indole-2-carboxamido)-3-(5-methy...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50315979(3-(4-((1H-pyrazol-1-yl)methyl)-2-(2-(naphthalen-2-...)
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35751(cis-1,2-diaminocyclohexane derivative, 8h)
Affinity DataIC50: 1.40nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35769(cis-1,2-diaminocyclohexane derivative, 5j)
Affinity DataIC50: 1.40nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50315981(3-(4-((1H-pyrazol-1-yl)methyl)-2-(naphthalen-1-ylm...)
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50317912(3-[4-[(2,5-Difluorophenoxy)methyl]-2-({[(1R)-1-(3,...)
Affinity DataIC50: 1.60nMAssay Description:Antagonist activity at mouse EP3alpha receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50317895(3-[4-[(2,5-Dimethylphenoxy)methyl]-2-({[(1R)-1-(3,...)
Affinity DataIC50: 1.70nMAssay Description:Antagonist activity at mouse EP3alpha receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255631(N-[(1R,2R,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50317907(3-[4-[(3-Chlorophenoxy)methyl]-2-({[(1R)-1-(3,5-di...)
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at mouse EP3alpha receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50317908(3-{2-({[(1R)-1-(3,5-Dimethylphenyl)-3-methylbutyl]...)
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity at mouse EP3alpha receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50340864(2-(4-(5-chloro-1H-indole-2-carboxamido)-3-(5-methy...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50340874(3-(4-(5-chloro-1H-indole-2-carboxamido)-3-(5-methy...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50308905(3-[2-({[3-Methyl-1-(1-naphthyl)butyl]amino}carbony...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at mouse EP3alpha receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50317896(3-{2-({[(1R)-1-(3,5-Dimethylphenyl)-3-methylbutyl]...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at mouse EP3alpha receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50317904(3-(4-[(3,5-Dimethylphenyl)amino]-2-{[(1R)-1-(3,5-d...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at mouse EP3alpha receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35756(cis-1,2-diaminocyclohexane derivative, 8m)
Affinity DataIC50: 2.10nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255577(N-{(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50340872(2-(4-(5-chloro-1H-indole-2-carboxamido)-3-(5-methy...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35743(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Affinity DataIC50: 2.30nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35743(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Affinity DataIC50: 2.30nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255205(N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35743(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50107587(CHEMBL3601910)
Affinity DataIC50: 2.40nMAssay Description:Negative allosteric modulator activity against human mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced inositol phosphate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255207(N-{(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50340868(2-(4-(5-chloro-1H-indole-2-carboxamido)-3-(5-methy...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255159(N-{(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50317910(3-[4-[(3-Cyanophenoxy)methyl]-2-({[(1R)-1-(3,5-dim...)
Affinity DataIC50: 2.70nMAssay Description:Antagonist activity at mouse EP3alpha receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50340876(1-((4-(5-chloro-1H-indole-2-carboxamido)-3-(5-meth...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50307447(3-[4-[(3-Cyanophenoxy)methyl]-2-({[1-(4-fluoro-3-m...)
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase intracellular calcium level in prese...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255204(N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50317901(3-[4-(3,5-Dimethylphenoxy)-2-({[(1R)-1-(3,5-dimeth...)
Affinity DataIC50: 2.90nMAssay Description:Antagonist activity at mouse EP3alpha receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50317916(3-[4-[(2-Chlorophenoxy)methyl]-2-({[(1R)-1-(3,5-di...)
Affinity DataIC50: 2.90nMAssay Description:Antagonist activity at mouse EP3alpha receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35762(cis-1,2-diaminocyclohexane derivative, 5c)
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35759(cis-1,2-diaminocyclohexane derivative, 8p)
Affinity DataIC50: 3.20nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50307443(3-{2-({[1-(3,5-Dimethylphenyl)-3-methylbutyl]amino...)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase intracellular calcium level in prese...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50307445(3-[4-[(3-Cyanophenoxy)methyl]-2-({[1-(3-methoxyphe...)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase intracellular calcium level in prese...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35765(cis-1,2-diaminocyclohexane derivative, 5f)
Affinity DataIC50: 3.30nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50317911(3-[4-[(2,4-Difluorophenoxy)methyl]-2-({[(1R)-1-(3,...)
Affinity DataIC50: 3.30nMAssay Description:Antagonist activity at mouse EP3alpha receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35773(cis-1,2-diaminocyclohexane derivative, 48)
Affinity DataIC50: 3.40nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255576(N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM35753(cis-1,2-diaminocyclohexane derivative, 8j)
Affinity DataIC50: 3.5nMpH: 7.4 T: 2°CAssay Description:The in vitro anti-fXa activity was measured by using a chromogenic substrate S-2222 and human fXa. Aqueous DMSO or test compounds in aqueous DMSO and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255206(N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50255575(N-[(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]ami...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Sankyo

LigandPNGBDBM50340870(2-(4-(5-chloro-1H-indole-2-carboxamido)-3-(5-methy...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human factor 10a using S2222 chromogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50307449(3-[4-[(2,3-Difluorophenoxy)methyl]-2-({[1-(3,5-dim...)
Affinity DataIC50: 3.60nMAssay Description:Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase intracellular calcium level in prese...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50307448(3-[4-[(3-Cyanophenoxy)methyl]-2-({[1-(3,4-dimethox...)
Affinity DataIC50: 3.70nMAssay Description:Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase intracellular calcium level in prese...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50307437(3-[4-[(3-Chlorophenoxy)methyl]-2-({[1-(3,5-dimethy...)
Affinity DataIC50: 3.80nMAssay Description:Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase intracellular calcium level in prese...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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