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TargetMu-type opioid receptor(Mouse)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50408679(CHEMBL5287792)
Affinity DataKi:  0.00260nMAssay Description:Displacement of [3H] DAMGO from mouse MOR expressed in CHO cell membrane incubated for 90 mins by scintillation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Mouse)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50408509(CHEMBL5277326)
Affinity DataKi:  0.00340nMAssay Description:Displacement of [3H] DAMGO from mouse MOR expressed in CHO cell membrane incubated for 90 mins by scintillation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Graduate University of The Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM11593(5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(3,5-dime...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM21008((4S,7S,13S)-13-[(2S)-2-amino-3-(4-hydroxyphenyl)pr...)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at DOR (unknown origin) expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 60 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243920((S)-2-((3,4-dichlorophenyl)(methyl)amino)-N-methyl...)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Mouse)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50408675(CHEMBL5270915)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H] DAMGO from mouse MOR expressed in CHO cell membrane incubated for 90 mins by scintillation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243868((+/-)-2-((3,4-dichlorophenyl)(methyl)amino)-N-meth...)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244020(4'-[1-({2-[Cyanomethyl-(3,4-dichloro-phenyl)-amino...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to human urotensin-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50032737(CHEMBL3354718)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of BACE1 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
National Demonstration Center For Experimental Chemistry Education

Curated by ChEMBL
LigandPNGBDBM50602006(CHEMBL5209436)
Affinity DataKd:  0.340nMAssay Description:Binding affinity to Helicobacter pyroli urease assessed as dissociation constant by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50463294(CHEMBL4249256)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]U69,593 from human KOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50209744((R)-3-(4-fluorophenyl)-N-((R)-7-(piperidin-1-ylmet...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50377218(CHEMBL257171)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]hU-2 from human recombinant Urotensin 2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50007344(2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2-pyr...)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50463297(CHEMBL4246433)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]DAMGO from human MOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50377220(CHEMBL255509)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]hU-2 from human recombinant Urotensin 2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50506108(CHEMBL4449252)
Affinity DataKi:  0.470nMAssay Description:Displacement of [3H]U69593 from human KOR expressed in CHO cell membranes incubated for 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Fudan University

LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.480nMAssay Description:The transfection of plasmid and membrane preparations was conducted as described in our previous report, with 0.7 nm [3H] SCH23390 (D1R) or [3H]Spipe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50061587(CHEMBL3394051)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BACE1 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50061594(CHEMBL3394041)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BACE1 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50463297(CHEMBL4246433)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]U69,593 from human KOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50377217(CHEMBL256989)
Affinity DataKi:  0.600nMAssay Description:Displacement of [125I]hU-2 from human recombinant Urotensin 2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50061585(CHEMBL3394049)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of BACE1 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50408509(CHEMBL5277326)
Affinity DataEC50:  0.700nMAssay Description:Agonist activity at MOR (unknown origin) expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 60 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetB1 bradykinin receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50322858((R)-3-phenyl-N-((R)-6-(3-(pyrrolidin-1-yl)prop-1-e...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]Lys-desArg9-BK from human bradykinin B1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50061582(CHEMBL3394039)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of BACE1 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetMu-type opioid receptor(Mouse)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50408677(CHEMBL5274117)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H] DAMGO from mouse MOR expressed in CHO cell membrane incubated for 90 mins by scintillation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetB1 bradykinin receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50203200((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((R)-...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50061584(CHEMBL3394048)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of BACE1 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50209744((R)-3-(4-fluorophenyl)-N-((R)-7-(piperidin-1-ylmet...)
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50061580(CHEMBL3394057)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of BACE1 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIntegrin alpha-V/beta-3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50083761([3-Oxo-8-[3-(pyridin-2-ylamino)-propoxy]-2-(2,2,2-...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity for Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM21130(U69,593 | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspir...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]U69593 from human KOR expressed in CHO cell membranes incubated for 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50061593(CHEMBL3394040)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of BACE1 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50377215(CHEMBL257415)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]hU-2 from human recombinant Urotensin 2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50463294(CHEMBL4249256)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human KOR expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding based liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Fudan University

LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  1.08nMAssay Description:The transfection of plasmid and membrane preparations was conducted as described in our previous report, with 0.7 nm [3H] SCH23390 (D1R) or [3H]Spipe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50377227(CHEMBL255462)
Affinity DataKi:  1.20nMAssay Description:Displacement of [125I]hU-2 from human recombinant Urotensin 2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50083763([(S)-8-[2-(6-Methylamino-pyridin-2-yl)-ethoxy]-3-o...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity for Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50061599(CHEMBL3394046)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of BACE1 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50083764([3-Oxo-8-[3-(pyridin-2-ylamino)-propoxy]-2-(2,2,2-...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity for Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224213(2-(o-toluidino)-5-isopropylthiazol-4(5H)-one | CHE...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human 11-beta-HSD1 in presence of 3% HSA by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50322870((R)-3-(4-fluorophenyl)-N-((R)-6-(3-(pyrrolidin-1-y...)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at human bradykinin B1 receptor assessed as inhibition of Lys-desArg9-BK-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50061588(CHEMBL3394052)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of BACE1 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details Article
PubMed
TargetMu-type opioid receptor(Mouse)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50408673(CHEMBL5275873)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H] DAMGO from mouse MOR expressed in CHO cell membrane incubated for 90 mins by scintillation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50078697({(S)-7-[2-(1H-Imidazol-2-ylamino)-ethylcarbamoyl]-...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity towards human Vitronectin receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Mouse)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50408676(CHEMBL5272258)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H] DAMGO from mouse MOR expressed in CHO cell membrane incubated for 90 mins by scintillation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054826([7-([4,4']Bipiperidinyl-1-carbonyl)-3-oxo-4-phenet...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of binding to purified integrin alphaIIb-beta3 of human plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50054827({8-[(4-Carbamimidoyl-phenyl)-methyl-carbamoyl]-3-o...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of binding to purified integrin alphaIIb-beta3 of human plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072493([(S)-7-[(1H-Benzoimidazol-2-ylmethyl)-methyl-carba...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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