Compile Data Set for Download or QSAR
Report error Found 12248 with Last Name = 'zak' and Initial = 'm'
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50155245(CHEMBL3774897)
Affinity DataIC50: 0.00600nMAssay Description:Displacement of [125I]Endothelin-1 from human recombinant Endothelin-B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM22567(CHEMBL511 | PYRILAMINE | 3H]pyrilamine | N-[2-(dim...)
Affinity DataIC50: 0.0140nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 1/2/3(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50155248(CHEMBL3774478)
Affinity DataIC50: 0.0160nMAssay Description:Displacement of [125I]apamin from rat cerebral cortex small conductance calcium-activated potassium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50155246(CHEMBL3775234)
Affinity DataIC50: 0.0230nMAssay Description:Displacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM521949(N-[3-[6-(difluoromethoxy)-2- methyl-3-oxo-4H-1,4- ...)
Affinity DataKi:  0.0300nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50326519((E)-N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM82505(CAS_121881 | NSC_121881 | SB204070)
Affinity DataKi:  0.0300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM521947(US11155557, Example 93 | US11155557, Example 94 | ...)
Affinity DataKi:  0.0300nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM603021(N-(3-(5-chloro-2- (difluoromethoxy)phenyl)-1H- pyr...)
Affinity DataKi:  0.0400nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM521924(US11155557, Example 14 | N-[3-[6-(difluoromethoxy)...)
Affinity DataKi:  0.0400nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM50545960(CHEMBL4740778 | US11649241, Example 9)
Affinity DataKi:  0.0420nMAssay Description:Inhibition of recombinant human JAK2 (812 to 1132 residues) expressed in insect cells using Y1-B as substrate incubated for 30 mins by microfluidic m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM50545980(CHEMBL4764019)
Affinity DataKi:  0.0450nMAssay Description:Inhibition of recombinant human JAK2 (812 to 1132 residues) expressed in insect cells using Y1-B as substrate incubated for 30 mins by microfluidic m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM50545979(CHEMBL4742159)
Affinity DataKi:  0.0470nMAssay Description:Inhibition of recombinant human JAK2 (812 to 1132 residues) expressed in insect cells using Y1-B as substrate incubated for 30 mins by microfluidic m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM521949(N-[3-[6-(difluoromethoxy)-2- methyl-3-oxo-4H-1,4- ...)
Affinity DataKi:  0.0500nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM521949(N-[3-[6-(difluoromethoxy)-2- methyl-3-oxo-4H-1,4- ...)
Affinity DataKi:  0.0500nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM521931(US11155557, Example 21 | N-[5-[6-(difluoromethoxy)...)
Affinity DataKi:  0.0500nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM521947(US11155557, Example 93 | US11155557, Example 94 | ...)
Affinity DataKi:  0.0500nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM521924(US11155557, Example 14 | N-[3-[6-(difluoromethoxy)...)
Affinity DataKi:  0.0500nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM521947(US11155557, Example 93 | US11155557, Example 94 | ...)
Affinity DataKi:  0.0500nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM522020(US11155557, Example 110 | N-[3-[6-(difluoromethoxy...)
Affinity DataKi:  0.0500nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM50545987(CHEMBL4746726)
Affinity DataKi:  0.0520nMAssay Description:Inhibition of recombinant human JAK2 (812 to 1132 residues) expressed in insect cells using Y1-B as substrate incubated for 30 mins by microfluidic m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM50545986(CHEMBL4789075)
Affinity DataKi:  0.0570nMAssay Description:Inhibition of recombinant human JAK2 (812 to 1132 residues) expressed in insect cells using Y1-B as substrate incubated for 30 mins by microfluidic m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM232618(US9346815, 164 | US9604984, Example 164)
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM521950(US11155557, Example 40 | N-[3-[6-(difluoromethoxy)...)
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM522062(US11155557, Example 152 | N-[3-[5-(difluoromethoxy...)
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM521935(US11155557, Example 25 | N-[3-[5-(difluoromethoxy)...)
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM521951(US11155557, Example 41 | N-[3-[6-(difluoromethoxy)...)
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Human)
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50266122(CHEMBL4070789)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of recombinant human C-terminal 6xHis-tagged 15-PGDH expressed in Escherichia coli using PGE2 as substrate after 15 mins in presence of NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM603012(2-amino-N-(3-(5-chloro-2- (difluoromethoxy)phenyl)...)
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM521922(US11155557, Example 12 | N-[3-[6-(difluoromethoxy)...)
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM522050(US11155557, Example 140 | N-[1-(cyanomethyl)-3-[6-...)
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM522051(US11155557, Example 142 | N-[3-[6-(difluoromethoxy...)
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM232618(US9346815, 164 | US9604984, Example 164)
Affinity DataKi:  0.0600nM ΔG°:  -57.8kJ/molepH: 7.2 T: 2°CAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2017
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM521949(N-[3-[6-(difluoromethoxy)-2- methyl-3-oxo-4H-1,4- ...)
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM522037(US11155557, Example 127 | N-[3-[6-(difluoromethoxy...)
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 4(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM82505(CAS_121881 | NSC_121881 | SB204070)
Affinity DataKi:  0.0600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM521949(N-[3-[6-(difluoromethoxy)-2- methyl-3-oxo-4H-1,4- ...)
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM521949(N-[3-[6-(difluoromethoxy)-2- methyl-3-oxo-4H-1,4- ...)
Affinity DataKi:  0.0700nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 4(Guinea pig)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM82505(CAS_121881 | NSC_121881 | SB204070)
Affinity DataKi:  0.0700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
Tokyo Medical and Dental University

Curated by ChEMBL
LigandPNGBDBM50198707((2Z)-(20S)-1alpha,25-dihydroxy-2-[2''''-(fluoroeth...)
Affinity DataEC50:  0.0700nMAssay Description:Inhibition of human VDR induced-transcriptional transactivation of luciferase reporter gene in COS7 cells after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM522000(US11155557, Example 90 | N-[3-[6-(difluoromethoxy)...)
Affinity DataKi:  0.0700nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM522000(US11155557, Example 90 | N-[3-[6-(difluoromethoxy)...)
Affinity DataKi:  0.0700nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM522007(N-[3-[6-(difluoromethoxy)-2- methyl-3-oxo-4H-1,4- ...)
Affinity DataKi:  0.0700nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM521931(US11155557, Example 21 | N-[5-[6-(difluoromethoxy)...)
Affinity DataKi:  0.0700nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM521947(US11155557, Example 93 | US11155557, Example 94 | ...)
Affinity DataKi:  0.0700nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM521947(US11155557, Example 93 | US11155557, Example 94 | ...)
Affinity DataKi:  0.0700nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM232751(US9346815, 297 | US9604984, Example 297)
Affinity DataKi:  0.0700nM ΔG°:  -57.4kJ/molepH: 7.2 T: 2°CAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2017
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM232751(US9346815, 297 | US9604984, Example 297)
Affinity DataKi:  0.0700nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM521947(US11155557, Example 93 | US11155557, Example 94 | ...)
Affinity DataKi:  0.0700nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM50545944(CHEMBL4744172)
Affinity DataKi:  0.0710nMAssay Description:Inhibition of recombinant human JAK2 (812 to 1132 residues) expressed in insect cells using Y1-B as substrate incubated for 30 mins by microfluidic m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
Displayed 1 to 50 (of 12248 total ) | Next | Last >>
Jump to: