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TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193657(CHEMBL3955994)
Affinity DataKd:  37nMAssay Description:Binding affinity to EZH2 (unknown origin) expressed in baculovirus infected SF9 cells co-expressing SUZ12/EED/RbAp48 complex by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193717(CHEMBL3932025)
Affinity DataKd:  252nMAssay Description:Binding affinity to EZH2 (unknown origin) expressed in baculovirus infected SF9 cells co-expressing SUZ12/EED/RbAp48 complex by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394184(CHEMBL2158860)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394176(CHEMBL2158861)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394177(CHEMBL2158862)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394185(CHEMBL2158864)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394179(CHEMBL2158865)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394175(CHEMBL2158858)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35595(pyrazolo pyrimidine, 28)
Affinity DataIC50: 0.0800nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM50316254(methyl 4-(6-(4-(3-(4-(2-hydroxyethyl)phenyl)ureido...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394166(CHEMBL2158859)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394165(CHEMBL2158866)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35592(pyrazolo pyrimidine, 24)
Affinity DataIC50: 0.200nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM50316255(Isopropyl 4-(6-(4-(3-Methylureido)phenyl)-4-morpho...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394164(CHEMBL2158011)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394174(CHEMBL2158863)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35593(pyrazolo pyrimidine, 25)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM50316256(isopropyl 4-[6-(4-{[(2-fluoroethyl)carbamoyl]amino...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35594(pyrazolo pyrimidine, 27)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM50316257(1-{4-[1-(1-benzylpiperidin-4-yl)-4-morpholin-4-yl-...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM50316258(methyl 4-(6-{4-[(anilinocarbonyl)amino]phenyl}-4-m...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35589(pyrazolo pyrimidine, 21)
Affinity DataIC50: 0.320nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35594(pyrazolo pyrimidine, 27)
Affinity DataIC50: 0.340nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35578(pyrazolo pyrimidine, 10)
Affinity DataIC50: 0.380nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM50316253(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35578(pyrazolo pyrimidine, 10)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35591(pyrazolo pyrimidine, 23)
Affinity DataIC50: 0.450nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35585(pyrazolo pyrimidine, 18)
Affinity DataIC50: 0.460nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM50316259(isopropyl 4-(6-{4-[(cyclopropylcarbamoyl)amino]phe...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35591(pyrazolo pyrimidine, 23)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM50316260(tert-butyl 4-[6-(4-{[(2-fluoroethyl)carbamoyl]amin...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35580(pyrazolo pyrimidine, 13)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35585(pyrazolo pyrimidine, 18)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35580(pyrazolo pyrimidine, 13)
Affinity DataIC50: 0.520nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM50316261(methyl 4-(4-morpholino-6-(4-(3-(4-(2-morpholinoeth...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35590(pyrazolo pyrimidine, 22)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM50316262(tert-butyl 4-(6-{4-[(cyclopropylcarbamoyl)amino]ph...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35590(pyrazolo pyrimidine, 22)
Affinity DataIC50: 0.610nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM50316263(1-{4-[1-(1-Benzylpiperidin-4-yl)-4-morpholin-4-yl-...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM50316264(tert-Butyl 4-(6-(4-(3-Methylureido)phenyl)-4-morph...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM50316265(4-(4-morpholino-6-(4-(3-(4-(2-(pyrrolidin-1-yl)eth...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM50316266(methyl 4-(6-(4-(3-(4-(2-(4-methylpiperazin-1-yl)et...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM50316267(1-{4-[1-(1-benzylpiperidin-4-yl)-4-morpholin-4-yl-...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM50316281(1-{4-[1-(1-benzylpiperidin-4-yl)-4-morpholin-4-yl-...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35586(pyrazolo pyrimidine, 26)
Affinity DataIC50: 0.830nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35588(pyrazolo pyrimidine, 20)
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35584(pyrazolo pyrimidine, 17)
Affinity DataIC50: 1.10nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35579(pyrazolo pyrimidine, 6)
Affinity DataIC50: 1.40nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM50316280(1-{4-[1-(1-benzylpiperidin-4-yl)-4-morpholin-4-yl-...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35577(pyrazolo pyrimidine, 12)
Affinity DataIC50: 1.5nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
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