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Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611953(CHEMBL5289716)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human 11beta-HSD1 in liver microsome incubated for 24 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50542251(CHEMBL4647011)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50542256(CHEMBL4648027)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50542266(CHEMBL4633397)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50098037(4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against human Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlpha-2A adrenergic receptor(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50087151(1N-{10-[2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a...)
Affinity DataKi:  0.390nMAssay Description:Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611950(CHEMBL5280689)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells incubated for 24 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataKi:  0.420nMAssay Description:Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Jumbo Drug Bank

US Patent
LigandPNGBDBM326211(3-[(3R)-1- acryloylpiperidin-3-yl]-1- (4-phenoxyph...)
Affinity DataIC50: 0.730nMAssay Description:1. Reaction conditions: buffer conditions: 20 mM HEPES (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mm Na3VO4, 2 mm DTT, 1% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
US Patent

TargetAlpha-2A adrenergic receptor(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50087149(1N-{8-[2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,...)
Affinity DataKi:  0.760nMAssay Description:Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50353386(US8592410, 88 | CHEMBL1829763 | US8598163, 61 | US...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human 11beta-HSD1 incubated for 22 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Yes(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human YesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50087152(1N-{7-[2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,...)
Affinity DataKi:  0.870nMAssay Description:Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50322229(4-(4-Iodophenyl)-1-((4-methoxy-1H-indol-3-yl)methy...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]methylspiperone from human D2L receptor expressed in HEK cell membrane after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Jumbo Drug Bank

US Patent
LigandPNGBDBM613984(US11739090, Compound 7B)
Affinity DataIC50: 0.930nMAssay Description:1. Reaction conditions: buffer conditions: 20 mM HEPES (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mm Na3VO4, 2 mm DTT, 1% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
US Patent

TargetNeuropeptide S receptor(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50443390(CHEMBL1474387)
Affinity DataIC50: 0.960nMAssay Description:Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM378885(US10266537, Compound 93)
Affinity DataIC50: 1nMAssay Description:Inhibition of human full length recombinant YES using poly(Glu,Tyr)4:1 as substrate incubated for 40 mins in presence of [gamma33P-ATP] by radiometri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086454(CHEMBL3425518)
Affinity DataIC50: 1nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611950(CHEMBL5280689)
Affinity DataIC50: 1nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells incubated for 24 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611946(HSD-016 | Hsd-016)
Affinity DataIC50: 1nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50542261(CHEMBL4644391)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at D2 receptor (unknown origin) by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
The Brigham and Women'S Hospital

US Patent
LigandPNGBDBM603776(US11654147, Compound 213)
Affinity DataIC50: 1nMAssay Description:In this reporter gene cell based ALK2 and TGFβ assay, the C2Cl2 cell line was employed for the measurement of ALK2 activity, using a BRE-Luc SMA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

Target5-hydroxytryptamine receptor 1A(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50542253(CHEMBL4635414)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50628664(CHEMBL5415711)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNeuropeptide S receptor(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50322839(rac-N-(3-methyl-1-morpholinopentan-3-yl)-N-((1-met...)
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered sal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50087145(1N-{12-[2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetNeuropeptide S receptor(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50443390(CHEMBL1474387)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetNeuropeptide S receptor(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50322839(rac-N-(3-methyl-1-morpholinopentan-3-yl)-N-((1-met...)
Affinity DataIC50: 1.30nMAssay Description:Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50087148(1N-{9-[2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50542263(CHEMBL4638430)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50087147(1N-{6-[2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]methylspiperone from human D2L receptor expressed in HEK cell membrane after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50542263(CHEMBL4638430)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at D2 receptor (unknown origin) by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50542267(CHEMBL4649106)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50542250(CHEMBL4638599)
Affinity DataEC50:  1.70nMAssay Description:Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50087154(1N-{5-[2-hydroxy-(1R,2S,4aR,13bS,14aS)-1,2,3,4,4a,...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50542252(CHEMBL4644352)
Affinity DataEC50:  1.80nMAssay Description:Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at 5-HT2C receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataKi:  2nMAssay Description:Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086455(CHEMBL3426219)
Affinity DataIC50: 2nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086457(CHEMBL3426217)
Affinity DataIC50: 2nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM82487(TMQ, 3',5'-Diiodo)
Affinity DataKi:  2nMAssay Description:Binding Affinity against human beta-2 adrenergic receptor expressed in Chinese hamster ovary(CHO) cells was measured by using [125I]ICYP radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
The Brigham and Women'S Hospital

US Patent
LigandPNGBDBM603863(US11654147, Compound 313 | US11654147, Compound 33...)
Affinity DataIC50: 2nMAssay Description:In this reporter gene cell based ALK2 and TGFβ assay, the C2Cl2 cell line was employed for the measurement of ALK2 activity, using a BRE-Luc SMA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086451(CHEMBL3426222)
Affinity DataIC50: 2nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM378885(US10266537, Compound 93)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant ABL (27 to end residues) using EAIYAAPFAKKK as substrate incubated for 40 mins in presence of [gamma33P-ATP] by radio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]methylspiperone from human D3 receptor expressed in HEK293 cell membrane after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50542258(CHEMBL4634009)
Affinity DataEC50:  2nMAssay Description:Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Jumbo Drug Bank

US Patent
LigandPNGBDBM613974(US11739090, Compound 5B | US11739090, Compound 3B)
Affinity DataIC50: 2.16nMAssay Description:1. Reaction conditions: buffer conditions: 20 mM HEPES (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mm Na3VO4, 2 mm DTT, 1% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
US Patent

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