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TargetNEDD8-activating enzyme E1 catalytic/regulatory subunit(Human)
University of Macau

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataEC50:  3.40E+3nMAssay Description:Inhibition of NAE-mediated Ubcl2-NEDD8 conjugation in human Caco2 cells after 16 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
University of Macau

Curated by ChEMBL
LigandPNGBDBM67690(SMR000058480 | DHAD | 1,4-bis[2-(2-hydroxyethylami...)
Affinity DataEC50:  1.30E+3nMAssay Description:Inhibition of NAE-mediated Ubcl2-NEDD8 conjugation in human Caco2 cells after 16 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphoglycerate mutase 1(Human)
Ningbo University

Curated by ChEMBL
LigandPNGBDBM50612454(CHEMBL5290502)
Affinity DataEC50:  3.30E+4nMAssay Description:Inhibition of human PGAM1 in human MDA-MB-231 cells assessed as decrease in PGAM1 activity incubated for 2 hrs by UV/Vis spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetPhosphoglycerate mutase 1(Human)
Ningbo University

Curated by ChEMBL
LigandPNGBDBM50103572(CHEMBL3335789)
Affinity DataKd:  7.20E+3nMAssay Description:Binding affinity to PGAM1 (unknown origin) assessed as dissociation constant by fluorescence-based assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50620488(CHEMBL5414697)
Affinity DataKd:  1.19E+4nMAssay Description:Binding affinity to Keap1 (unknown origin) assessed as dissociation constant incubated for 200 sec by sensor chip immobilization based surface plasmo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50096348(2-Cyano-3,12-Dioxooleana-1,9(11)-Dien-28-Oic Acid ...)
Affinity DataKd:  4.87E+4nMAssay Description:Binding affinity to Keap1 (unknown origin) assessed as dissociation constant incubated for 200 sec by sensor chip immobilization based surface plasmo...More data for this Ligand-Target Pair
In DepthDetails
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400902(CHEMBL2204360 | vortioxetine hydrobromide | 1-(2-(...)
Affinity DataEC50:  200nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400902(CHEMBL2204360 | vortioxetine hydrobromide | 1-(2-(...)
Affinity DataEC50:  2.10E+3nMAssay Description:Agonist activity at human 5HT3A receptor expressed in xenopus oocytes by electrophysiological methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 1B(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400902(CHEMBL2204360 | vortioxetine hydrobromide | 1-(2-(...)
Affinity DataEC50:  120nMAssay Description:Partial agonist activity at human 5HT1B receptor expressed in CHO cells assessed as [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM85330(NSC_68647 | CAS_68647 | ONDANSETRON | Ondansetron ...)
Affinity DataIC50: 0.0900nMAssay Description:Antagonist activity at human 5HT3A receptor expressed in xenopus oocytes assessed as inhibition of 5HT-induced effect by electrophysiological methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50108151(N-{2,3-Dihydroxy-1-[4-(4-trifluoromethoxy-phenoxy)...)
Affinity DataIC50: 0.0920nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 3A(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM85330(NSC_68647 | CAS_68647 | ONDANSETRON | Ondansetron ...)
Affinity DataIC50: 0.160nMAssay Description:Binding affinity to rat 5HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 3A(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400902(CHEMBL2204360 | vortioxetine hydrobromide | 1-(2-(...)
Affinity DataIC50: 0.180nMAssay Description:Binding affinity to rat 5HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50108131(N-Hydroxy-N-{1-hydroxymethyl-2-[4-(4-trifluorometh...)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50108163(N-Hydroxy-N-{1-(2-hydroxy-ethoxymethyl)-2-[4-(4-tr...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50385603(CHEMBL2041308)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50108171(N-Hydroxy-N-{3-hydroxy-2-hydroxymethyl-1-[4-(4-tri...)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50385604(CHEMBL2041307)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50128610(2-(4-Methoxy-benzenesulfonyl)-4-methylene-2-(2-met...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50108143(4-{3-(Formyl-hydroxy-amino)-4-[4-(4-trifluorometho...)
Affinity DataIC50: 0.530nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Youngene Therapeutics

US Patent
LigandPNGBDBM402285(US10011627, 1)
Affinity DataIC50: 0.580nMAssay Description:The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetNeuropeptide Y receptor type 5(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50354066(CHEMBL1836324)
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50108138(N-Hydroxy-N-{3-(4-methanesulfonyl-piperazin-1-yl)-...)
Affinity DataIC50: 0.790nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuropeptide Y receptor type 5(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50354070(CHEMBL1836319)
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50108150(N-{1-Dimethylaminomethyl-2-[4-(4-trifluoromethoxy-...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50108156(N-Hydroxy-N-{1-methoxymethyl-2-[4-(4-trifluorometh...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50108136(4-{3-(Formyl-hydroxy-amino)-4-[4-(4-trifluorometho...)
Affinity DataIC50: 0.980nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50385606(CHEMBL2043425)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50385607(CHEMBL2043424)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50: 1.20nMAssay Description:Binding affinity to ALK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 2(Human)
Youngene Therapeutics

US Patent
LigandPNGBDBM402292(US10011627, 8)
Affinity DataIC50: 1.21nMAssay Description:The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetNeuropeptide Y receptor type 5(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50354068(CHEMBL1836322)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50108157(N-[2-[4-(4-Chloro-phenoxy)-benzenesulfonyl]-1-(3,4...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50108146(N-Hydroxy-N-{1-(3-methyl-2,6-dioxo-3,6-dihydro-2H-...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Youngene Therapeutics

US Patent
LigandPNGBDBM402293(US10011627, 9)
Affinity DataIC50: 1.49nMAssay Description:The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50108140(N-{2-(Formyl-hydroxy-amino)-3-[4-(4-trifluorometho...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50108149(N-Hydroxy-N-{3-morpholin-4-yl-1-[4-(4-trifluoromet...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 82 | US10633379, Example 35)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of BRD4-BD2 (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 3 hr by HTRFMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNeuropeptide Y receptor type 5(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50354072(CHEMBL1836317)
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50108169(N-[2-[4-(4-Cyano-phenoxy)-benzenesulfonyl]-1-(3,4,...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Youngene Therapeutics

US Patent
LigandPNGBDBM402291(US10011627, 7)
Affinity DataIC50: 1.82nMAssay Description:The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetNeuropeptide Y receptor type 5(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50354064(CHEMBL1836326)
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVasopressin V1a receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225162((4R)-N-[2-(dimethylamino)ethyl]-1-({4-[(2-phenylbe...)
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50108134(N-Hydroxy-N-{4-morpholin-4-yl-4-oxo-1-[4-(4-triflu...)
Affinity DataIC50: 2nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50385605(CHEMBL2040991)
Affinity DataIC50: 2nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50108153(N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-2-[4-(4-triflu...)
Affinity DataIC50: 2nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50108130(N-{1-(4,4-Dimethyl-2,5-dioxo-imidazolidin-1-ylmeth...)
Affinity DataIC50: 2nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50108155(N-Hydroxy-N-{1-pyridin-2-yl-2-[4-(4-trifluorometho...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50581158(CHEMBL5084695)
Affinity DataIC50: 2.5nMAssay Description:Binding affinity to ALK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Youngene Therapeutics

US Patent
LigandPNGBDBM402290(US10011627, 6)
Affinity DataIC50: 2.59nMAssay Description:The following method was used to determine the inhibitory activity of the compounds of the present invention on SGLT1 and SGLT2. The experimental met...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

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